Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Brain metastasis"”.
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ARFGEF mutations: A mechanism for breast-to-brain metastasis
… cells to other parts of the body, known as metastasis. Similarly, around 80% of deaths resulting from breast cancer are due to metastasis. Approximately 15-25% of breast tumours metastasise to the brain, and the outlook for patients with breast-to-brain metastasis is poor. Although it is …
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Investigation of the role of ARFGEF3 in breast to brain metastasis
… common for breast tumours to metastasize to the brain and these metastatic tumours are incurable. Breast to Brain metastasis occurs when the primary breast tumour breaks down and these cancer cells spread to the brain and start proliferating, forming tumours in the brain. A series of recent …
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Microenvironment-Induced Pten Loss By Exosomal Microrna Primes Brain Metastasis Outgrowth
… lose PTEN expression after dissemination to the brain, but not to other organs. PTEN level in PTEN-loss brain metastatic tumor cells is restored after leaving brain microenvironment. This brain microenvironment-dependent, reversible PTEN mRNA and protein down-regulation is epigenetically …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
<p>Breast cancer brain metastases have remained one of the most intense challenges for precision cancer therapeutics, but current treatment options are limited and not curative. Recently, our lab reported that adoptive <em>PTEN</em> downregulation in metastatic breast tumor cells activates …
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In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis
<p>Brain metastasis, which frequently arises from breast cancer, lung cancer, melanoma, and colorectal cancer, remains a severely unmet medical need and its incidence continues to rise while treatment options remain palliative. To better understand the biology underlying its aggressive, incurable …
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Role of miR-4732-3p in breast cancer brain metastasis and brain metastatic tumor microenvironment
… that may play important roles in breast cancer brain metastasis (BCBM). To this end, we conducted miRNA-sequencing of extracellular vesicles isolated from the serum samples of 6 BCBM patients and 8 Stage I/II/III breast cancer patients, and identified 49 circulating miRNAs that were upregulated …
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The Role of Type I Insulin-Like Growth Factor Receptor Signaling In Breast Cancer Brain Metastasis
<p>Brain metastasis is a common cause of mortality in cancer patients. Approximately 20-30% of breast cancer patients acquire brain metastasis, yet potential therapeutic targets remain largely unknown. The type I insulin-like growth factor receptor (IGF- IR) is known to play a role in the …
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Prophylactic Cranial Irradiation Reduces The Incidence of Brain Metastasis In A Mouse Model of Metastatic Breast Cancer
… irradiation (PCI) is a preventative whole-brain irradiation technique used to reduce the incidence of brain metastasis and improve overall survival in select patients with small cell lung cancer and acute lymphoblastic leukemia. A population of breast cancer patients – stage IV, HER2+ or …
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Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
Metastasis is the principle cause of the deaths among breast cancer patients. Brain is one of the major sites of metastasis in breast cancer; however, the pathological mechanism is poorly understood. One of critical steps of brain metastasis is the breaching of the BBB and this process is …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor …
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Harnessing Cancer Omics to Inform Precision Oncology
… the tumor microenvironment of melanoma brain metastasis (MBM) during anti-PD1 therapy using single cell RNA sequencing (scRNA-seq) of patients’ cerebrospinal fluid (CSF) samples. We profiled functional proteomics from kidney tumor samples using reverse phase protein array (RPPA) and …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… second most common cancer to metastasize to the brain. Current standard of care for breast cancer brain metastases (BCBM) involves surgical resection of individual lesions and whole brain radiotherapy (WBRT) for multiple lesions, however, effective FDA-approved drugs for patients with …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
Tumour metastasis to the brain is a common and deadly development in certain cancers; 18-30% of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms plays in metastasis to the brain is not well understood. To identify epigenetic drivers of …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… resistance which is prevalent in melanoma brain metastasis. Specifically, this research work sought to determine whether somatic mutations identified in the plasma samples of patients with glioma were identical or representative of the somatic mutations in synchronously obtained glioma …
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Cancer Proliferation at the Brain Metastatic Site: A Proteomic Exploration of Inter-Cellular Cross-talk Sustained by Cell-membrane/Secretome Interactions
Brain metastasis of breast cancer is one of the leading causes of mortality in patients suffering from cancer. The unique structure and components of the brain microenvironment, including the brain-blood barrier and the immune-suppressive environment, present significant clinical challenges to …
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Intravital imaging of metastasis in zebrafish
Metastasis is the cause of the overwhelming majority of cancer deaths. However, it remains a poorly understood process. The events at the metastatic site are especially poorly comprehended. These events are dynamic and so require intravital imaging to investigate. However, the intravital imaging of …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… In many cases primary breast tumours that metastasise to the brain occur. Brain tumours are heterogenous malignancies with a low survival rate. Tumours often development therapy resistance by secreting different pro-angiogenic growth factors that allow them to overcome the effect of …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… potential biomarker discovery in breast cancer brain metastasis and SARS-CoV-2. The presented studies investigate the glycan analysis from breast cancer cells for identifying potential biomarkers. On top of that, glycan biomarker studies are discussed for exploring potential biomarkers …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
… radiosensitizes IBC cells in vitro [23], and brain metastases have strong expression of cholesterol-regulation genes compared to lung metastases <em>in vivo</em> [unpublished]. Delaying whole-brain irradiation (WBI) beyond 21 days is insufficient to reduce the incidence of brain metastases …
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