Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Brain mapping"”.
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Integrated and scalable molecular brain mapping
Understanding the brain requires integrative knowledge of its cellular-, network-, and system-level architectures. Existing volume imaging techniques have proven the potential to provide such information, but the lack of technology to label large volumes for visualization has limited their utility. …
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From fMRI to fUSI: advancing large-scale brain mapping in rodents
Investigating the principles that underlie human brain function lies at the heart ofneuroscience. Among the available tools, functional magnetic resonance imaging (fMRI) has become the reference method for mapping large-scale brain activity in humans. Its non-invasive nature, high spatiotemporal …
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Automated Brain Mapping to Evaluate the Relationship between Neurodegeneration, Cerebral Small Vessel Disease and Structural Covariance Network Disruption in Alzheimer's Disease
… unclear but are thought to target large-scale brain systems. It is posited that disease of the brainâ s small blood vessels may contribute to AD progression by disrupting structural brain networks that subserve complex cognitive routines. Therefore, the overarching aim of this dissertation is …
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Information -Theoretic Approach to Deformable Image Transformations With Application to Brain Image Segmentation
… images. It is also incorporated into a brain image segmentation method under development at the University of Illinois. Potential applications include image segmentation, functional brain mapping, and automatic target recognition.
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Network approaches to understanding the functional effects of focal brain lesions
… connectivity have emerged as a paradigm shift in brain mapping over the past decade. Despite significant attention within the neuroimaging and cognitive neuroscience communities, these approaches have hitherto not been extensively explored in neurosurgery. The aim of this thesis is to investigate …
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Pre-operative Functional Magnetic Resonance Imaging: Application to Tumour Resection by Awake Craniotomy
The management of brain tumours in eloquent areas remains challenging. Surgical intervention is currently the primary method of treatment, with the surgeon attempting to maximize tumour resection while simultaneously sparing healthy cortex. Pre-operative and intra-operative brain mapping techniques …
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Obtaining optimal data length for FMRI images
Interest in brain hemodynamics has led to a substantial increase in state of the art research within the field of functional Magnetic Resonance Imaging (fMRI). FMRI enables research to be conducted on brain mapping in healthy individuals, as well as in patient populations. The need for accurate …
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Statistical methods for fMRI data analysis
… resonance imaging (fMRI) has dominated the brain mapping field and it has been proved a powerful tool for mapping human brain functions. The fMRI is a high spatial-temporal resolution medical-imaging modality, which means the data structure is complicated and the data size is huge. These …
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Developing High-Density Diffuse Optical Tomography for Neuroimaging
Clinicians who care for brain-injured patients and premature infants desire a bedside monitor of brain function. A decade ago, there was hope that optical imaging would be able to fill this role, as it combined fMRI's ability to construct cortical maps with EEG's portable, cap-based systems. …
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An Anatomically Representative Atlas-Based Finite Element Model of the Human Brain for Studying Brian Injury Biomechanics: Development, Validation and Comparison to Existing Models
Traumatic brain injury (TBI) is a leading cause of disability and injury-related death. To enhance our ability to prevent such injuries, we can study brain response using validated finite element (FE) models. In the current study, a high-resolution, anatomically accurate FE model was developed from …
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Study of Lorentz Effect Imaging and Neuronal Current MRI Using Electromagnetohydrodynamic Models
… study to directly map electrical activity in the brain using MRI, which has many benefits over functional MRI. One potential ncMRI method, Lorentz effect imaging (LEI), has shown promise but needs a better theoretical understanding to improve its use.</p><p>We develop three computational models to …
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Neuroplasticity, Neurorehabilitation, and New Hope for Brain-Injured Persons
… last twenty-five years, treatment for Traumatic Brain Injury (TBI) has stagnated, which has relegated many TBI survivors to permanent disability or premature death. The reasons for this stagnation are arguably historical. In the mid nineteenth century, Paul Pierre Broca established localization …
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Analysis of The Operation Result Against Metastatic Brain Tumor
… 3(7.14%)례였는데 순수하게 수술과 연관도 합병증은 2례였다. 추후 대뇌 지도화(brain mapping)에 대한 연구가 좀더 활발해지면 전이성 뇌종양에 대한 수술적 치료의 영역이 더욱 확대될 것으로 사료된다. "
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Improved Methods for Motion-Compensating and Event-Related Spinal Functional Magnetic Resonance Imaging (fMRI)
… become a widely used technique for non-invasive brain mapping, and methods have now evolved to allow fMRI of the spinal cord (spinal fMRI) as well. With the goal of improving spinal fMRI, the studies presented herein have investigated potential sources of noise that might limit its sensitivity …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… and physiological functions in the living brain. In vivo brain mapping with PET or SPECT can be of great importance in drug development as well as in the effective diagnosis, treatment and management of neurological and psychiatric disorders and substance abuse. Therefore, the development …
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Multi-level models of language comprehension in the mind and brain
… the consequences of these interventions in a brain mapping evaluation. We apply this method in an fMRI brain decoding study, which reveals findings about the time-course of human syntactic representations. The second study integrates an LLM into a structured model of auditory word recognition, …
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Hierarchical Bayesian Models for Multimodal Neuroimaging Data
… rise to a large number of in vivo techniques for brain mapping. This wide range of structural and functional imaging modalities provides a major source of information-rich data which may be used to non-invasively understand the human brain, and is a promising source of information for improved …
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Synaptome mapping of glutamatergic synapses across the mouse brain
… a new method, the Genes to Cognition Synaptome Mapping pipeline (G2CSynMapp), to map individual synapses at the whole-brain level, in a quantitative and unbiased manner. This method was used to generate PSD95 and SAP102 synaptome maps – i.e. comprehensive maps of PSD95 and SAP102 positive …
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Scalable Subcellular Resolution Mapping of the Human Brain
… However, we still lack technologies for mapping the connectivity as well as molecular details of individual cells in the human nervous system, at the microscopic scale and human brain-wide scale. This thesis aims to develop various chemical and computational technologies as part of a …
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Univariate and Multivariate fMRI Investigations of Delay Discounting and Episodic Future Thinking in Alcohol Use Disorder
… of substance abuse disorders, including AUD. Brain mapping of DD routinely uses modalities such as blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI). However, the extent to which these brain activation maps reflect the characteristics of impulsive behavior has …
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