Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Brain lesions"”.
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Network approaches to understanding the functional effects of focal brain lesions
… connectivity have emerged as a paradigm shift in brain mapping over the past decade. Despite significant attention within the neuroimaging and cognitive neuroscience communities, these approaches have hitherto not been extensively explored in neurosurgery. The aim of this thesis is to investigate …
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Brain Lesions and Habituation of the Head-Shake Response in the Rat
Made available in DSpace on 2014-12-08T23:02:12Z (GMT). No. of bitstreams: 1 7013466.pdf: 4113516 bytes, checksum: 0dd393cce7040c189f0e67c9d11720b9 (MD5) Previous issue date: 1969
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NEURAL MECHANISMS SUPPORTING COGNITIVE INFLUENCES ON SUPRASPINAL NOCICEPTIVE PROCESSING: INSIGHTS FROM BRAIN LESIONS
… information unique to each individual from brain areas involved in memory, attention, and affect to influence cortical processing of nociceptive information. Specifically, these mechanisms may involve the direct modulation of various nociceptive processing brain areas as well as the …
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Automatic detection and segmentation of brain lesions from 3D MR and CT images
The detection and segmentation of brain pathologies in medical images is a vital step which helps radiologists to diagnose a variety of brain abnormalities and set up a suitable treatment. A number of institutes such as iThemba LABS still rely on a manual identification of abnormalities. A manual …
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The Safety and Cost-Effectiveness of Carotid Angioplasty and Stenting in Calgary
… Findings were correlated with 24-hour MRI brain lesions using a binomial regression model. Results Stenting was more expensive than endarterectomy ($6106.84 incremental cost) and had a lower effectiveness (- 0.12 QALYs). Results were influenced by the procedure costs and were sensitive to …
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Multiple Sclerosis: Studies of the Interferon system and search for infectious agents
… system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. Interferons (IFNs) are naturally occurring proteins known to have antiviral, …
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Amyloid Fibril Nucleation In Reverse Micelles
… large quantities, but normally cleared from the brain before it exerts any apparent toxicity. Under some conditions, however, it undergoes a conformational change and aggregates into fibrils. These fibrils then coalesce into amyloid plaques, which are the pathognomonic brain lesions of …
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Elucidating the Role of the Essential Kinase TgGSK in the Human Parasite Toxoplasma Gondii
… can lead to toxoplasmosis, which can include brain lesions and lead to death. Similarly, toxoplasmosis can result in birth defects, brain swelling, and blindness of a developing fetus in the case of a congenital infection. With minimal treatments for toxoplasmosis available, it is crucial to …
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The Role of the Multiple-Demand System in Fluid Intelligence and Selective Attention: Insights from Lesion and Neuroimaging Studies
… I draw on evidence from patients with focal brain lesions and healthy adults using neuropsychology, functional neuroimaging (functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG)), and multivariate pattern analysis techniques to investigate the role of the MD system in …
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Fluid Flow Characterization and In Silico Validation in a Rapid Prototyped Aortic Arch Model
… invasive technique has shown to cause ischemic brain lesions, or “silent infarcts”, in 90% of TAVR patients, which can increase the patient’s risk for stroke by two to four times in future years [3]. Claret Medical Inc., a medical device company, has developed a cerebral protection system that …
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Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease
… target that is highly upregulated in MS brain lesions and may potentially represent both an inflammatory biomarker and a therapeutic target for the monitoring and treatment of MS. However, its pathological significance is not well understood. While experimental autoimmune …
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End-to-end testing of the Leksell Gamma Knife Icon system
… system that is used to non-invasively treat brain lesions. It incorporates 192 fixed cobalt-60 sources, which ensures the highest degree of accuracy during treatment due to the minimization of potential error from stationary sources. The gamma knife’s precision and special modifications for …
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Identification of Intracranial Lesions With Dual-Energy Computed to mography and Magnetic Resonance Phase Imaging
… Single-energy Computed Tomography (SECT), lesions with an attenuation greater than 100 Hounsfield Units (HU) can be definitively diagnosed as calcification. However, low-density calcifications and hemorrhage may have overlapping attenuation ranges between 40 and 100 HU and, therefore, …
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Spatiotemporal Dynamics of Tissue Oxygenation in Awake, Behaving Mice
Brain arterioles respond to local neural activity by altering regional blood flow patterns in a manner which optimizes oxygen supply to respiring cells (‘functional hyperemia’). Recent studies of functional hyperemia in awake rodents shows a bimodal arteriole diameter increase when neural activity …
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Methods for Data Management in Multi-Centre MRI Studies and Applications to Traumatic Brain Injury
… implemented are then applied to traumatic brain injury (TBI) data.Firstly, a pre-processing pipeline for both anatomical and diffusion MRI was proposed, that allows for a high throughput of MRI scans. After describing the choices for processing tools,the performance of the integrated …
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Ultra-high Field MRI Methods for Precise Anatomical and Spectroscopic Measurements in the Brain and Application to Neurological and Neuropsychiatric Diseases
… imaging technique which facilitates detection of brain lesions and visualization of the brain overall. However, limitations in contrast and resolution at clinical field strengths may hinder investigation of the underlying biological mechanisms of these diseases. Ultra-high field MRI scanners, such …
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Cytosolic Nucleic Acid Sensing and Senescence in a Patient-Derived Model of Progressive Multiple Sclerosis
… cells resembling neural stem cells within brain lesions of patients with P-MS. Prior research demonstrates that directly induced neural stem cells (iNSCs) derived from patients with P-MS exhibit an inherent senescent phenotype and intrinsic dysfunctions including heightened inflammation and …
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Contusion Progression in Traumatic Brain Injury
Cerebral contusions that result from brain trauma have the propensity to enlarge over the days following injury, including extension of the haemorrhage core and swelling of the surrounding peri-contusional brain. This secondary injury increases the likelihood of death and severe disabil- ity, and …
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Neural substrate of emotion in man : a study in methodology
… processes can be selectively disturbed after brain damage. However, emotional and cognitive deficits usually co-exist in a particular patient, and the relationship between cognition and emotion is discussed. Animal data indicate that, following an initial sensory analysis in primary and …
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Development of new radiopharmaceuticals targeting the Cholecystokinin 2 receptor
… Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram”. Gli aspetti legati alla produzione dei radiofarmaci, dalla produzione degli isotopi radioattivi alle sintesi dei radiofarmaci e relativi controlli di qualità, sono stati approfondito oggetto di …
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