Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Brain disorders"”.
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FUNCTIONAL NETWORK CONNECTIVITY IN HUMAN BRAIN AND ITS APPLICATIONS IN AUTOMATIC DIAGNOSIS OF BRAIN DISORDERS
The human brain is one of the most complex systems known to the mankind. Over the past 3500 years, mankind has constantly investigated this remarkable system in order to understand its structure and function. Emerging of neuroimaging techniques such as functional magnetic resonance imaging (fMRI) …
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
… and glia that interact to facilitate complex brain functions. However, studying their development over decades has been technically challenging due to limitations in data access and representation. Recent advances in single-cell profiling have provided a wealth of data on fetal and adult human …
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Data-driven Methods for Resting-state fMRI Biomarker Discovery in Mental Illness
… the first of which is the characterization of brain networks in functional magnetic resonance imaging (fMRI) and dynamic functional network connectivity (dFNC) states. We posed three specific research questions to address several limitations in the current literature and enhance the …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… isoforms is associated with a wide range of brain disorders including psychological, neurological and developmental disorders. Unfortunately, currently available drugs targeting Nav channels are directed against highly conserved domains of the α-subunit of all Nav channels, and as such they …
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Development of a subcortical emphasized physical human head model for evaluation of deep brain source contribution to scalp EEG
… utilized in clinical and research settings for brain disorder related disease monitoring and cognitive science studies. Quantifying EEG rhythms through low resolution brain electromagnetic tomography (LORETA) analysis could further provide important biomarkers to determine the underlying …
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Development of positioning devices for MRI-guided high intensity focused ultrasound (HIFU) for abdominal, thyroid and brain, tumours
… procedures in many areas such as the brain, eye, breast, kidney, liver, pancreas, thyroid, uterine fibroids and pancreas. Meanwhile, new investigations are underway for treading cardiac arithmia, strokes, palliative pain treatment of bone metastases and brain disorders such as …
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Zebrafish and Conditioned Place Preference: A Translational Model of Drug Reward
… gained popularity as a model organism of complex brain disorders (e.g., substance use disorder). Behavioral quantification within the conditioned place preference (CPP) paradigm serves as a measure of the rewarding qualities of a given stimulus (e.g., drug). If animals develop an increase in …
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How Neuronal Stem Cells Acquire and Maintain their Identity
… which are required for the function of the human brain. However, the knowledge behind these progenitor cell’s type, fate and maintenance in mammals is still very fragmented. Within Drosophila, four different types of progenitors with partially identified regulator gene networks generate the brain. …
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Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
… reported to affect inflammatory events in the brain and many other tissues, however, these inflammatory events as well as the subtype(s) of nucleotide receptor(s) influencing these events have not been well defined. This dissertation examines the expression patterns of P2X and P2Y nucleotide …
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Devices for Extracellular Detection of Astrocytic Infraslow Electrophysiological Biomarkers
… with neurons and thus play a crucial role in brain information processing. This discovery, long overlooked due to the dominance of neuronal research, has prompted a significant reconsideration of their importance in understanding brain function. These cells are known from intracellular studies …
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A Study of Resting State FMRI Dynamic Functional Network Analysis of MTBI
Mild Traumatic Brain Injury (MTBI) is one of the most common neurological disorders. A subset of patients develop persistent cognitive deficits. A number of the brain studies have been conducted to discover the abnormalities and disruptions in the brain functional networks using similar methods to …
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Genetic and behavioral discrimination of dopamine 1 and 5 receptors in hippocampal dependent memory consolidation
… (DA) containing neurons project throughout the brain. DA has been implicated in mediating brain disorders such as Schizophrenia, Parkinson's disease, Huntington's disease and drug addiction. The role of DA in working memory and procedural learning is also well established. DA is a ubiquitous …
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Visual Exploration And Information Analytics Of High-Dimensional Medical Images
… in the field of neuroimaging. The analysis of brain images has uncovered amazing traits about its underlying dynamics. Multiple image modalities capture qualitatively different internal brain mechanisms and abstract it within the information space of that modality. Computational studies based …
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Assessment of Brain Perfusion and Vascular Compliance with Magnetic Resonance Imaging
Brain perfusion is an index that reflects the amount of blood received by the brain tissue in a given time period. Normal brain perfusion ensures that sufficient oxygen, glucose, and other nutrients are delivered to the neurons and glial cells in the brain. While perfusion is relatively static …
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Passive Acoustic Mapping of Microbubbles in Focused Ultrasound Induced Brain Therapies for Preclinical Studies
Safe and targeted agent delivery to the brain is critical in developing new therapies for highly prevalent brain disorders. Microbubble (MB) - mediated, focused ultrasound (FUS) can temporarily modulate blood-brain barrier permeability (BBBM) to enhance local agent delivery. To explore new brain …
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Awareness of Alzheimer's disease and Dementia among young adults: A Systematic Literature Review
… and dementia are both classified as severe brain disorders (AD), which pose substantial challenges to public health. A synthesis of research findings has examined the degree of cognisance among young adults worldwide. This literature review aimed to identify and synthesise existing research …
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Effects of diet on behavioural domains relevant to schizophrenia- a preclinical perspective
… therapeutic-like properties for human brain disorders. Finally, dietary choices of mothers have been found to have long-term behavioural and cognitive effects in their offspring. In this thesis, I examined the effect of high fat diet (HFD) in two mutant mouse models for the genetic risk …
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The Influence of Age, Gender, and Thiol Repletion in an In Vivo Model of Lewy Body Disorders
<p>Lewy body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but …
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Modulation of Brain Tissue Transport and Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier by Transcranial Direct Current Stimulation
… non-invasive approach to treat a broad range of brain disorders and to enhance memory and cognition in healthy individuals. In addition to directly acting on neurons by modulating the membrane potential, inducing neuronal polarization and changing cortical excitability in the brain to achieve its …
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Characterisation of a protease-dependent gene regulation system for gene therapy applications
… the utility of this system for the treatment of brain disorders associated with increased activation of proteases.
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