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Showing 1 to 20 of 111 for “"Brain derived neurotrophic factor"”.
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Regulation of Brain-Derived Neurotrophic Factor in the Adult Mouse Brain
In the adult central nervous system (CNS) brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection and synaptic plasticity among other functions. However, relatively little is known of its regulation. In this thesis, we attempted to learn more about BDNF regulation by means …
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Expression und Funktion von Brain-derived-neurotrophic-factor in humanen Podozyten
Der derzeitige Kenntnisstand betreffend des neuronalen Wachstumsfaktors BDNF beruht überwiegend auf neurobiologischen Untersuchungen. Daher bleibt die mögliche Bedeutung einer in jüngster Zeit beobachteten BDNF-Expression auch in nicht-neuronalen Geweben zukünftig weiter abzuklären. <br> <br>In …
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Effect of low endogenous brain-derived neurotrophic factor levels on striatal dopamine dynamics
… hyperactivity disorder (ADHD), and depression is brain-derived neurotrophic factor (BDNF). As a trophic factor, BDNF role is to assist in the growth, survival, and differentiation of neurons. However, there is increasing evidence that BDNF may mediate neurotransmitter dynamics. Our goals were to …
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Regulation of brain-derived neurotrophic factor in the neuroendocrine melanotrope cell of Xenopus laevis
Contains fulltext : 147013.pdf (Publisher’s version ) (Open Access)
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Brain derived neurotrophic factor and structural vascular disease in black Africans : the SABPA study
Motivation - Brain-derived neurotrophic factor (BDNF) is a protein complex, synthesised and secreted mainly by the central nervous system and is involved in neuronal maintenance. Research suggests that BDNF is implicated in various neurological and psychiatric diseases, while recent evidence …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
<p>Brain-derived neurotrophic factor (BDNF) is a neurotrophin required for the differentiation, growth, and survival of neurons. BDNF is synthesized in several tissue types including skeletal muscle. Neuromuscular diseases (NMDs) are characterized by the degeneration of motorneurons and/or …
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Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
… on molecular and cellular adaptations in the brain that result from chronic drug exposure (Fitzgerald and Nestler, 1995 ). This suggests that chronic alcohol abuse involves stable changes in the brain at the molecular and cellular levels responsible for long-lasting alterations in behavior. …
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Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.
… ion may be mediated through regulation of brain-derived neurotrophic factor (BDNF). Recently, lithium ion has been shown to selectively protect spinal motor neurons in animal models of amyotrophic lateral sclerosis (ALS) by preventing the apoptosis component. In this study, investigation …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS
… of progressive pathology may be a reduction in brain-derived neurotrophic-factor (BDNF) signaling at the motor unit. We have shown that mice deficient in skeletal muscle-synthesized BDNF (msBDNF) demonstrate progressive motorneuron and muscle pathology at 120d. We hypothesize mitochondrial …
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Influence of Brain Derived Neurotrophic Factor and Family History of Alcohol Dependence on Alcohol Use in Healthy Social Drinkers
Brain-derived neurotrophic factor (BDNF) is important for neuronal survival, differentiation and consolidation of synaptic strength. Studies have found increased alcohol use and genetic risk for alcohol dependence in individuals with the Val66Met single-nucleotide polymorphism (SNP) of the BDNF …
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Interplay of Brain Derived Neurotrophic Factor and Protein Kinase A in Modulating Mitochondrial Structure and Function in Brain Homeostasis and Disease
… neuronal networks, neurons rely on continuous neurotrophic support mediated by Brain-Derived Neurotrophic Factor (BDNF). My dissertation work characterized new physiological roles that BDNF play in maintaining neuronal homeostasis, specifically by regulating mitochondrial structure and function …
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THE ROLE OF SKELETAL MUSCLE SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) ON THE HEALTH AND MAINTENANCE OF THE MURINE MOTOR UNIT
… various myokines, including tumor necrosis factor alpha, IL-6, IL-8, IL-15, IL-17, and brain-derived neurotrophic factor (BDNF) (Pederson, 2011, So et al., 2014, Schnyder and Handschin, 2015). BDNF is a small neurotrophic protein, that regulates neuron differentiation, maturation, and …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the subventricular zone (SVZ) lining the lateral …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
<p>Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB …
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Brain derived neurotrophic factor (BDNF): Untersuchungen zur Expression und Regulation in vitro sowie zur funktionellen Relevanz in der experimentellen autoimmunen Enzephalomyelitis (EAE)
Das Neurotrophin Brain derived neurotrophic factor (BDNF) ist essenziell für die Entwicklung und den Erhalt des Nervensystems. Seine Expression ist nicht nur auf Neuronen begrenzt, sondern wurde auch in Immunzellen, wie z.B. in den Infiltraten in Multiple Sklerose Läsionen, detektiert. Zahlreiche …
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Smooth Muscle-Specific Removal of Brain-Derived Neurotrophic Factor Results in Increased Vagal Afferent Innervation to the Intestine and Increased Satiation in Mice
… afferents transmit signals regarding food-derived stimuli in the gastrointestinal (GI) tract to the brain. Vagal mechanoreceptors called intraganglionic laminar endings (IGLEs) innervate the smooth muscle wall of GI organs and detect stretch and tension to regulate GI reflexes and …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… amyloid-β40/42 (Aβ), and higher levels of mature brain-derived neurotrophic factor (mBDNF) when compared to A549 cell media. In conjunction to this the levels of soluble amyloid precursor protein α (sAPPα) were higher in H1299 cell media compared to A549 cell media. With these previous findings, …
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Prenatal Intravenous Nicotine Exposure: Increased Motivation For Methamphetamine Self-Administration, Altered Methamphetamine-Induced Locomotor Activity and Brain-Derived Neurotrophic Factor Protein Levels In Adult Rats
<p>The age at which drug use begins is a critical factor in predicting future drug use liability. It is uncommon for individuals older than 25 to initiate drug use and progress to drug abuse. Thus, adolescence is a developmental period of considerable importance for investigating drug abuse …
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Die Konzentrationen von Brain-Derived-Neurotrophic-Factor (BDNF) und Neurotrophin (NT 3) in humanem Hirngewebe bei der Demenz vom Alzheimer-Typ und Psychosen aus dem schizophrenen Formenkreis
In der Vergangenheit wurden zahlreiche Untersuchungen durchgeführt, um die Bedeutung Neurotropher Faktoren (NTF) in der Pathogenese der Alzheimer Demenz bzw. schizophrener Psychosen besser zu verstehen, um daraus therapeutische Schlüsse zu ziehen (Hefti und Weiner, 1986; Koliatsos et al., 1991; …
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