Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Brain aging"”.
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A role for nutrition in healthy brain aging
… understand nutrition’s impact on cognition and brain health across the life span. While accumulating evidence indicates healthy cognitive aging is dependent upon both brain health and nutritional status, the relationship between nutrition, cognition, and brain structure and function remains to …
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A voxel-level approach to brain age prediction: A quantitative method to assess regional brain aging
Global brain age has been used as an effective biomarker to study the correlation between brain aging and neurological disorders. However, brain aging is a regional phenomenon, a facet that remains relatively under-explored within the realm of brain age prediction research using machine learning …
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Characterization of the Dunkin Hartley guinea pig as a non-transgenic and multimorbid model of brain aging
… pre-clinical models, that express a specific brain aging pathology. Recent discoveries, however, have identified a dynamic whole-body "inflammaging" phenotype that exists with, and likely contributes to, AD/ADRD onset and progression. Currently, we do not have an accessible and tractable …
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Mitochondrial Dynamics Imbalance as a Potential Driver of Neuronal Decline in the Aging Nervous System of Lymnaea stagnalis
Aging is associated with a progressive decline in multiple physiological functions, including impairments in neuronal function and cognitive abilities such as learning and memory. As global populations age, elucidating the biological mechanisms underlying brain aging and cognitive decline has …
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Quantifying effects of aging across structures of the mouse auditory system, with in-vitro brain slice preparations
Aging is a process fundamentally different from those studied by most scientists. Whereas in the course of most scientific inquiry, engineers or scientists attempt to create order or elucidate how its complexity arises, aging is the study of precisely the opposite. How order decays, how and with …
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Aging Lowers Pex5 Levels In Cortical Neurons In Male and Female Mouse Brains
… enzymes, and amino acid degradation. In the brain, peroxisomal lipids make up the myelin sheath. Brain peroxisomal dysfunction leads to lipid disruption or neurological consequences if key peroxisomal proteins are absent. Still, it is unclear how peroxisomes are affected in neurodegenerative …
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Brain Structure in Older Adult Siblings
<p>Considerable variability exists in patterns of brain aging within and across individuals. Quantifying familial contributions to brain structure in late life may help us understand this variability. We estimated heritability of gray and white matter volumes and cortical thickness in a sample of …
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Fully Hyperbolic Graph Convolutional Neural Networks for Age Prediction with Multi-Modal Brain Data
Characterizing age-related alterations in MEG brain networks holds great promise in understanding aging trajectories and revealing aberrant patterns of neurodegenerative disorders, such as Alzheimer’s disease. In this study, we utilize a Fully Hyperbolic Neural Network (FHNN) to embed functional …
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Rejuvenation of The Epigenetic Landscape of The Aged Brain Through Manipulation of Circulating Factors
<p>The aging population of the United States is expanding at an alarming rate. The Center for Disease Control and Prevention estimates that the population of those age 65 years and older will reach over 50 million by 2020 and will double to 100 million by 2060. This will not only put a massive …
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The Effects of Historical Alcohol Use on Neuropsychological Functioning in Older Adults Following a Traumatic Brain Injury
… have experienced a moderate to severe traumatic brain injury. The research question being answered in the current study was if a history of alcohol abuse or dependence would worsen neuropsychological functioning in older adults who experienced at least one moderate to severe traumatic brain …
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An investigation of amygdala and hippocampal subregions and their relation to ageing in anxiety and related disorders
… SAD are associated with accentuated biological aging, as indexed by cellular and molecular markers. Nevertheless, little is known about brain aging in OCD and SAD, or the extent to which inconsistencies in hippocampal and amygdala volume findings in these disorders may be due to the differential …
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CARATTERIZZAZIONE DEI PIGMENTI DELL'INVECCHIAMENTO NEL CERVELLO UMANO:NEUROMELANINA E LIPOFUSCINE
… both accumulate in central nervous system with aging. The presence and the morphology of these substances have been described more than one century ago but in the past the two pigments haven’t been unmistakably distinct. Today is important to discriminate the two pigments and understand their …
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Effects of Aerobic Exercise on Cognitive and Cerebrovascular Function in Hypertensive Adults
… is widely recommended to combat vascular and brain aging in hypertension. We sought to compare the effects of a single bout of aerobic exercise on 1) arterial stiffness and cerebral hemodynamics and 2) cognitive function in middle-aged adults with controlled-hypertension and without …
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Cognitive Health in Black and Latina Midlife Women: The Role of Sleep and Vasomotor Symptoms
… for cognitive dysfunction is critical to promote brain health and reduce health disparities. Objective: The goal of this study was to examine associations between objectively measured sleep disturbance, vasomotor symptoms (VMS), rest-activity rhythms (RAR), and memory performance in Black and …
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The Relationships Among Age, Physical Activity, and Working Memory
… activity, which contributes to healthy adult brain aging.</p>
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MOLECULAR MECHANISM OF HIV-1 TAT INDUCED NEURONAL DYSFUNCTION
… and studies showed the persistence of HIV-1 in brain cells as well as the presence of viral proteins in CSF. This notion was supported by the compelling neuropathological data suggesting that the loss of Synaptic Plasticity occurs with the ongoing presence of virus and despite HAART. Clinically, …
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Intermittent fasting as a therapeutic strategy for alzheimer’s disease: behavioral and molecular evidence
… non-pharmacological intervention to improve brain health and mitigate neurodegenerative disease progression. Alzheimer’s disease (AD) is characterized by impaired metabolic functions that disrupt neuronal function and contribute to cognitive decline in aging populations. This dissertation …
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The Relationship of Coronary Atherosclerosis Progression to Cognition
… testing as part of the Dallas Heart and Brain Aging Study (DHBAS) at the UT Southwestern Alzheimer Disease Center. CAC progression was examined as an increase from baseline calcium levels and based on CAC progression groups (i.e., None, Incidence, Non-Progressor, Progressor) in …
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Sex Differences in the Relationship Between Physical Activity and Cognitive Health in Ethnically Diverse Older Adults
The global population is aging rapidly, accompanied by a rise in dementia cases, particularly among females and ethnic minority groups. Physical activity (PA) may mitigate the effects of aging on brain health and promote cognition in older adults, with benefits varying by biological sex and …
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How do occupational sedentary behavior and occupational cognitive complexity relate to cognitive function?
… inactivity have been associated with advanced brain aging and cognitive decline in older adulthood. However, sedentary behavior may have a more complex relationship with cognitive function due to cognitively complex occupations often being highly sedentary. OBJECTIVES: This study examined …
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