Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Brain ageing"”.
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Insulin/IGF-like signalling and brain ageing in Drosophila melanogaster
… last few decades, many studies have shown that ageing is modulated by the evolutionarily conserved nutrient-sensing Insulin/IGF-like signalling (IIS) pathway. IIS interacts with multiple cellular processes, including cell growth, development, metabolic homeostasis, fecundity and stress …
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DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
… the molecular mechanisms underlying healthy brain ageing in the exceptionally long-lived naked mole rat (NMR) and the role of the DNA damage response in the pathogenesis of Huntington's disease (HD). Multi-omic analyses of NMR brain ageing revealed a lack of a canonical ageing signature in …
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Investigation of brain ageing in HIV-positive individuals using convolutional neural networks
… (DL) have provided new means of tracking healthy ageing, and have established DL-predicted brain age as an accurate and reliable biomarker for brain health. Deviations from a healthy brain ageing trajectory, indicated by an increased predicted brain age relative to chronological age, and thus …
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Saliency Mapping in Convolutional Neural Networks to Determine Brain Age Trajectories
Brain Age (BA) estimation via Deep Learning has become a strong and reliable bio-marker for brain health, but the black-box nature of Neural Networks does not easily allow insight into the causal features of brain ageing. In this work, a ResNet model was trained as a BA regressor on T1 structural …
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Vinexin regulates autophagy through YAP/TAZ: implications for health and disease
… SORSB3 mRNA expression increases in normal human brain ageing, 2. SORBS3 is a candidate tumour suppressor in hepatocellular carcinoma (HCC). This dissertation builds on published data from an siRNA screen for autophagy regulations under basal conditions, which indicates vinexin knockdown …
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The brain age gap in social anxiety disorder
Background: When an individual's brain appears ‘older' than expected based upon their chronological age, they may be at an increased risk for developing brain-related diseases and cognitive decline. There is growing evidence of advanced brain ageing in neuropsychiatric diseases. Social anxiety …
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Modelling white matter pathology and establishing a novel ex-vivo platform for drug identification in neuroinflammation
… is detrimental to axons as well as overall brain function. Furthermore, this is a key hallmark, not only, of classical WM diseases including multiple sclerosis but also is observed in brain ageing and dementias including Alzheimer’s disease. Where, it is considered a key driver of cognitive …
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Untargeted metabolomics and proteomics application of mass spectrometry: from biomarker identification within cells to their spatial localization on tissues
… and pathological conditions including ageing and cancer.Time-dependent accumulation of DNA damage has been observed during senescence, the state of cell cycle arrest and resistance to death which has been recognised as a driver of the ageing process. Similarly, genomic instability can …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
Recently, leaders in human brain mapping and the clinical neurosciences outlined the need for prospective trials in neurosurgery to establish the clinical relevance of connectomics. This doctoral dissertation addresses this challenge by using diffuse gliomas as a model to study the principles of …
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CARATTERIZZAZIONE DEI PIGMENTI DELL'INVECCHIAMENTO NEL CERVELLO UMANO:NEUROMELANINA E LIPOFUSCINE
… the two pigments and understand their role in brain aging. Over the past years the capacity of neuromelanin and lipofuscine to interact with different cellular component and extra-cellular environment has been investigated. The role of these pigments in the pathogenesis of neurodegenerative …
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Understanding and stratifying brain health through blood-based omics data
Brain health across the lifespan is dynamic and influenced by a complex interplay of genetics and the environment. Age-related neurological diseases are a growing burden on healthcare systems and society. Individuals that do not have overt diagnoses of neurological diseases will still experience …
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
… physiological and pathological processes of the brain and neuronal tissues. They have been investigated for biomarker discovery of ageing, neuroinflammation and neurodegenerative disorders. The n-3 fatty acids EPA and DPA are thought to exhibit a range of neuroprotective effects many of which are …