Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Brain Morphology"”.
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Effects of environmental enrichment on personality traits in juvenile Arctic charr (Salvelinus alpinus) : interplay with brain morphology, growth performance and implication for welfare
… syndrome) as well as potential association with brain characteristics and growth for Arctic charr welfare implication. I found that physical environmental enrichment induces boldness consistency across long term period (Chapter 1), behavioural syndrome (Chapter 2), shyer individuals (Chapter 1), …
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… elucidate whether Sxc- signaling contributes to brain excitatory/inhibitory (E/I) balance in vivo. Using chemoconvulsants to uncover excitability changes in SLC7A11sut/sut mice — mice that are null for Sxc- because of a spontaneous mutation in exon 12 of SLC7A11 — we uncovered a sex-independent …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this dissertation used zebrafish as a tool to: i) Establish the developmental window of susceptibility for DomA toxicity, ii) Characterize the behavioral …
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Identification and characterisation of novel zebrafish brain development mutants obtained by large-scale forward mutagenesis screening
… screens performed to find new mutants affecting brain development, in particular mutants defective in development and function of the midbrain-hindbrain boundary (MHB), an organiser region that patterns the adjacent brain regions of the midbrain and the hindbrain. In the first screen, I could …
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Morphological alterations in frontotemporal dementia:
The present thesis explores alterations in brain morphology in the neurodegenerative disorder of frontotemporal dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion …
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Mechanisms of brain ventricle development
The brain ventricles are a conserved system of fluid-filled cavities within the brain that form during the earliest stages of brain development. Abnormal brain ventricle development has been correlated with neurodevelopmental disorders including hydrocephalus and schizophrenia. The mechanisms which …
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Bridging the link between trauma, brain development and depression: epigenetic mechanisms
… who have never been depressed on (1a) brain morphology and (1b) DNA methylation? We studied differences in the fronto-limbic system (a collection of areas responsible for emotion regulation) and methylation at the serotonin transporter (SLC6A4) and FK506 binding protein gene (FKBP5) …
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Evaluation of pig brain developmental patterns and the influence of dietary polar lipids on pig development
… in research examining human nutrition and brain development due to their similarities to humans in gastrointestinal development and brain morphology. As such, the neonatal pig has been suggested to be a great model for the neonatal human and due to its size, it has been utilized in magnetic …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this dissertation used zebrafish as a tool to: i) Establish the developmental window of susceptibility for DomA toxicity, ii) Characterize the behavioral …
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Grey matter morphological changes in late life using magnetic resonance imaging technique
… the relationship between cognitive function and brain morphology using regions of interest methodology, whole brain analyses have been generally lacking. The first topic is to examine the voxel‐wise correlation between GM volume and four cognitive domains. The findings are largely consistent with …
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Brain morphometry of HIV-infected children on early antiretroviral therapy (ART) from age 5 to 9 years
… children. Early HIV invasion of the developing brain is associated with neurodevelopmental delays and neurocognitive deficits including encephalopathy, slower processing speed, language impairment, lack of concentration and attentiveness, and psychomotor slowing. Alterations in the …
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Investigating the Impact of Metabolic Dysregulation on Nervous System Development and Function: A Study of CPT2 Deficiency in a Zebrafish Model System
… abnormal embryonic development that influences brain function by disrupting brain morphology, network formation, and gene expression associated with schizophrenia. To address the hypothesis, a zebrafish CPT2 deficient model system was developed to investigate CPT2 deficiency during early …
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Deep Learning for Brain Structural Connectivity Analysis: From Tissue Segmentation to Tractogram Alignment
… is a cornerstone in neuroimaging for studying brain anatomy and functions. Anatomical MRI images, such as T1-weighted (T1-w) scans, allow the non-invasive visualization of the brain tissues, enabling the investigation of the brain morphology and facilitating the diagnosis of both acquired …