Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Brain Microenvironment"”.
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The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… changes in molecular interplay between the brain extracellular matrix (ECM), oligodendrocyte progenitor cells (OPCs) and astrocytes. During ageing the resident brain progenitors undergo cellular arrest causing a diminished regenerative response. Increasing research evidence supports the …
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IN VITRO MODEL OF GLIOBLASTOMA TO STUDY THE EFFECTS OF BRAIN MICROENVIRONMENT AND ITS MECHANICAL PROPERTIES ON TUMOR CELLS
… (GBM) is one of most aggressive forms of brain cancer with a median survival rate of 14.6 months, and the two-year survival rate is 30%, which has not seen significant improvement in the last 100 years. This low survival rate could be in part attributed to the fact that there is a lack of …
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Microenvironment-Induced Pten Loss By Exosomal Microrna Primes Brain Metastasis Outgrowth
… and co-evolution with the drastically different microenvironments of metastatic sites. Cancer cells of common origin manifest distinct gene expression patterns after metastasizing to different organs. Clearly, the dynamic interplay between metastatic tumor cells and extrinsic signals at …
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Influence of the 3D microenvironment on glioblastoma migration and drug response
<p>Glioblastoma (GBM) is a highly invasive brain cancer characterized by poor prognosis. Despite significant efforts by the basic and clinical research community our understanding of GBM progression and recurrence has been incremental. Improvements in therapeutic response have been dismal, and GBM …
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A proteomics study to investigate the role of the neural niche in the development of metastatic HER2+ breast cancer
… organs in a process known as metastasis. The brain, which is shielded from the environment by the blood brain barrier, offers an immunocompetent lodging spot for the circulating cancer cells. Therefore, it is a "popular" destination for metastasized cancers which even surpass the incidents of …
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The Development of a Printable Device with Gravity-Driven Flow for Live Imaging Glioma Stem Cell Motility
… cells (GSCs), is frequently left behind in the brain parenchyma once the bulk of the tumor has been resected. Previous research has found that patient-derived GSCs displayed varying invasion responses with and without the presence of interstitial flow. Interestingly, GSCs from a single patient …
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Cancer Proliferation at the Brain Metastatic Site: A Proteomic Exploration of Inter-Cellular Cross-talk Sustained by Cell-membrane/Secretome Interactions
Brain metastasis of breast cancer is one of the leading causes of mortality in patients suffering from cancer. The unique structure and components of the brain microenvironment, including the brain-blood barrier and the immune-suppressive environment, present significant clinical challenges to …
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… immune cells of the CNS. Present throughout the brain parenchyma and in constant communication with the peripheral immune system, microglia are essential regulators of brain physiology. The adult human brain is prone to immune dysregulation in neurodegeneration and normal ageing. Understanding …
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In vitro modelling of human glioblastoma migration and angiogenesis
… and pathophysiological properties of the brain. This project focuses on the development of an injury-free ‘wound healing’ and a vascularised tumoroid in vitro model using patient-derived GBM cells. These models are used to recapitulate how individual components of the GBM's complex brain …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… patients showing metastatic lesions to the brain and a 30% five-year survival rate post-diagnosis, secondary tumors to the brain are a leading cause of cancer-related deaths. Understanding the mechanisms of tumor cell extravasation at the brain is therefore crucial to the development of …
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The Impact of Radiation on Glioblastoma Evolution
… is the most common and malignant primary adult brain cancer with a median survival of 15 months despite treatment with surgical resection followed by chemo-radiotherapy. The clonal diversity and evolutionary dynamics inherent to GBs is considered a major obstacle to effective treatment response. …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… system (CNS), the latter being composed of the brain and spinal cord that constitute the control center of all functions body. The brain microenvironment, essential for its normal function, is ensured by the blood–brain barrier (BBB), a physical physiological barrier that represents the major …
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Role of miR-4732-3p in breast cancer brain metastasis and brain metastatic tumor microenvironment
… that may play important roles in breast cancer brain metastasis (BCBM). To this end, we conducted miRNA-sequencing of extracellular vesicles isolated from the serum samples of 6 BCBM patients and 8 Stage I/II/III breast cancer patients, and identified 49 circulating miRNAs that were upregulated …