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Showing 1 to 16 of 16 for “"Brain Edema"”.
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A Model for Studying Vasogenic Brain Edema
… proven method for targeted drug delivery to the brain that circumvents the blood-brain barrier (BBB). Little study has been conducted in understanding CED in pathological brain states. This is of importance when dealing with chemotherapeutic agent delivery to brain tumors, where vasogenic edema …
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Mechanisms of Brain Edema Formation in Mouse Models of Intracerebral Hemorrhage
Perihematomal edema causes major neurologic deterioration following intracerebral hemorrhage (ICH), mainly resulting from the disruption of the blood-brain barrier (BBB) by multiple mediators, including inflammatory mediators and thrombin. The objective of our study was to investigate the …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
<p>Perinatal hypoxic-ischemic (HI) brain injury is a major cause of acute morbidity and chronic nemological mortality in infants and children, with a reported incidence of 2- 9 per 1000 births. The pathophyiological mechanisms leading to immature brain damage after HI are complex and relate to the …
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Glutamate Receptor-Mediated Taurine Release From The Hippocampus During Oxidative Stress
… linked to hippocampal swelling and cytotoxic brain edema in vitro. Swollen brain cells activate volume regulatory mechanisms including a significant efflux of the endogenous sulfonic amino acid taurine via volume-regulated anion channels (VRACs). Studies in brain slice preparations also …
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Role of Slit2 in Reducing Complications after Surgical Brain Injury
<p>Surgical brain injury (SBI) is the inadvertent injury to brain tissue at the perisurgical site which occurs due to neurosurgical maneuvers such as incision, retraction, and electrocoagulation that can result in post-operative complications. Blood brain barrier (BBB) disruption and …
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Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury
… of most neurosurgical procedures, the surgical brain injury (SBI) rodent model provides an ideal platform for preconditioning. Our work shows that preconditioning with Crotalus rattlesnake venom, known for its hemorrhagic and inflammatory effects, mitigates some harmful effects of SBI. We have …
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… detected in the central nervous system, reduce brain infarction volumes, and improve neurological behavior tests 24 hours after HIE. Administration of G-CSF was able to play a pivotal role in attenuating neuroinflammation and BBB disruption 48 hours following HIE. Similarly, OPN was able to …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… yuzu extract (YE) and hesperidin (HSP) prevented brain ischemia-induced brain edema in dose-dependent manners. Evans blue extravasation in the ischemic hemisphere of the mouse brain was also significantly reduced by treatment with the four materials. In addition, they inhibited the …
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The effect of calcium channel blocking agents on cold induced cerebral edema in mice
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Outcome von Ertrinkungsunfällen in Abhängigkeit von der Ursache und der Erstversorgung in der Bundesrepublik Deutschland
Ertrinkungsunfälle sind nicht nur in den USA und Australien, sondern auch in Deutschland ein häufiges Unfallgeschehen, vor allem im Kleinkindesalter. Im Alter von ein bis fünf Jahren stellt der Ertrinkungsunfall in Deutschland sogar die häufigste nichtnatürliche Todesursache dar. Durch die …
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Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
… hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine …
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Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura
El traumatismo craneoencefálico, es la epidemia silenciosa de nuestra época, que genera gastos en salud, en países como Estados Unidos, cercanos a los 60 billones de dólares anuales, y cerca de 400 billones en rehabilitación de los discapacitados. El pilar del manejo médico del trauma …
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MORPHOLOGICAL FEATURES OF THE REPRODUCTIVE ORGANS IN DOMESTIC SPECIES IN RELATION TO WATER MOVEMENT CONTROL, HYPONUTRITION AND ENVIRONMENTAL INFLUENCES IN FETAL AND PREPUBERTAL LIFE, AND METABOLISM REGULATOR FACTORS.
… treatment of variety of human disorders, such as brain edema, glaucoma, tumour growth, fertility and obesity in which water and small solute transport may be involved. Since multiple isoforms of AQPs are differentially expressed in cells and tissues, their localization to specific cells and …
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Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury
<p>Juvenile traumatic brain injury (jTBI) is the leading cause of death and disability in young children and adolescents. Despite its lasting detrimental effects on the developing brain, no pharmacological treatment exists. One of the pathological hallmarks of jTBI is edema. Astrocytes play a key …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
<p>Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… with disruption of blood flow to a part of the brain with rapid depletion of cellular energy and oxygen, resulting in ionic disturbances and eventually neuronal cell death [3]. The pathologic process that develops after stroke is divided into acute (within hours), sub-acute (hours to days), and …