Global ETD Search
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Showing 1 to 5 of 5 for “"Bptf"”.
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Development of peptide-based 19F MRI agents and BPTF-bromodomain inhibitors
… inhibitor of the bromodomain of a protein called BPTF, was discovered in the Pomerantz lab in 2015. As BPTF is a relatively understudied protein, there exists a need to improve the potency of AU1 as a probe for the various functions of its bromodomain, as it has been implicated in numerous …
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Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer.
… of E-cadherins, N-cadherins, and MHC-I genes in Bptf (an essential subunit of NURF) knocked down murine breast cancer cell lines. These proteins have well documented roles in the development and metastatic progression of cancers. To study the effect of Bptf knockdown on the development and …
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Role of Nucleosome Remodeling Factor (NURF) in Tumorigenesis Using a Breast Cancer Mouse Model
… NURF, due to knockdown of its essential subunits Bptf, showed reduction in tumor growth comparing to control tumors. The observed reduction in tumor growth was abrogated in immunodeficient mice lacking a functional immune system. Bptf KD and control 67NR cells grew at similar rates in vitro. …
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Understanding the pathogenesis of myotonic dystrophy type 1
… involvement; Kcnk4, Narg1, Ttyh1 and Bptf, potentially related to brain development; and Cacna1c, a promising candidate for heart conductance defects and sudden death.
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On the Role of Solvation in Ligand Binding: Structural and Thermodynamic Studies
<p>Water is known to be the matrix of life. Liquid water, which is present in every living organism, is indispensable for all biological processes. Doubtlessly, water molecules play a critical role in ligand binding. In spite of its fundamental thermodynamic impact, solvent energetics is often …