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Showing 1 to 20 of 21 for “"Box-Behnken Design"”.
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Statistical Analysis Of Diffusion Bonding Nickel Using Brass Interlayers
… surface finish, and foil thickness. A Box-Behnken design was selected to analyze the system for composition and strength of the bonded joints. Bonding of the materials was successful. The composition results proved to provide a good model with a fairly low standard error that can …
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Using TiO2 to Optimize the Photocatalytic Degradation of Kraft Black Liquor Using Response Surface Methodology
… organic carbon (TOC) reduction. A two-level 2k design was used as the preliminary study for examining the optimal initial concentration of black liquor and TiO2. A three-level Box-Behnken design (BBD) with three factors that included pH, temperature, and particle size was then applied to further …
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Development of standardized dry roasting procedures for Virginia type peanuts
… variety. A surface response model using the Box-Behnken design was developed for Behmor 2000AB and GeneCafe coffee roasters, for normal and high oleic peanuts respectively with sample size, roast time and power/temperature as dependent variables and L* as a response variable. The model for …
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Parametric study and simulation of microbubble column flotation
A study based on a statistically designed set of experiments (Box-Behnken design) has been conducted to determine the optimum conditions for advanced physical fine coal cleaning using microbubble column flotation. The dependent variables in these experiments were mass yield and product quality …
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Investigation of factors that influence coloration in polycarbonate based compounded plastics
… for example, statistical methods such as Box-Behnken design (BBD); characterization techniques such as thermogravimetric analysis (TGA); imaging and image analysis using scanning electron microscopy (SEM); numerical analysis of the kneading discs zone to evaluate the mixing efficiency …
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Pea Protein De-flavoring by Ozone
… three center points, were planned to utilize the Box-Behnken design for response surface analysis. Three factors were included in the design of experiment: ozone concentration, pH of the treatment solution, and reaction time. The optimal operating condition was identified as 100 ppb for ozone …
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Effects of acid hydrolysis conditions on cellulose nanocrystal yield and properties: A response surface methodology study
… for maximum CNC yield. Two experimental designs were tested and compared: the central composite design (CCD) and the Box–Behnken design (BBD). The three factors for the experimental design were acid concentration, hydrolysis temperature, and hydrolysis time. The responses quantified were …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… were optimized for maximum solubility using Box-Behnken design using JMP software. The design model was checked for validity by model fit analysis using ANOVA. Solubility for both drugs was increased by about 25 times. Drug release from modified and unmodified nanomicelles was observed to be …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… cocrystals, were synthesized. A Quality by Design (QbD) approach was used to construct the formulation. Dissolution and solubility were studied using UV imaging and High Performance Liquid Chromatography (HPLC). The polymorphic transitions of cocrystals and crystalline properties were …
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Construction and properties of Box-Behnken designs
Box-Behnken designs are used to estimate parameters in a second-order response surface model (Box and Behnken, 1960). These designs are formed by combining ideas from incomplete block designs (BIBD or PBIBD) and factorial experiments, specifically 2<sup>k</sup> full or 2<sup>k-1</sup> fractional …
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BIODIESEL PRODUCTION THROUGH MICROWAVE ASSISTED TRANSESTERIFICATION OF MICROBIAL CELLS
… with crude glycerol was conducted. Through Box-Behnken design and response surface methodology, the optimal temperature, pH, and glycerol concentration for yeast growth on pretreated crude glycerol was identified as 30.2 deg C, 6.0, and 19.8 g/L, respectively. Adopting these optimal …
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Reducing Dietary Crude Protein: Characterization of Branched-Chain Amino Acid Antagonism in Modern Broiler Chickens
… acids. Two experiments were conducted using Box-Behnken design to model the antagonism. Significant interactions were determined between isoleucine and valine that could not be replicated when leucine was removed from the model. Based on these findings, a large three factor factorial study …
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STUDY OF BIOGASIFICATION OF COAL TO METHANE FOR EX SITU AND IN SITU APPLICATIONS
… chloride. To maximize methane yield from coal, a Box-Behnken design necessitating 29 reactors was adopted to find the optimal nutrient conditions. The optimal condition provided by the Design of Expert (DOE) software was: Fe powder at 74 mM, methanol at 97.9 mM, ethanol at 100 mM, and trace …
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Enhancing the functionality of delactosed whey by enzymatic hydrolysis using Response Surface Methodology Approach (RSM)
… determine the optimal hydrolysis conditions, a Box-Behnken design with 4 independent variables at 3 levels was generated and implemented. The variables chosen, temperature (x1), enzyme-to-substrate (e/s) ratio (x2), time (x3) and pH (x4), are known to have the most significant influence on the …
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Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery
… window. Controlled drug delivery relies on the design and modification of specialised drug delivery systems (DDS) for encapsulating and delivering therapeutic agents. Biodegradable polymers have been exploited extensively for this purpose, since post-administrative procedures for removal of …
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Supercritical water gasification of lignocellulosic biomass materials for hydrogen production
… The response surface methodology using the Box-Behnken design was applied for the first time to optimize the process parameters during subcritical and supercritical water gasification of cellulose. The process parameters investigated include temperature (300-500 °C), reaction time (30-60 …
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PROPERTIES OF AQUEOUS-ALCOHOL-WASHED PROTEIN CONCENTRATES PREPARED FROM AIR-CLASSIFIED PEA PROTEIN AND OTHER AIR-CLASSIFIED PULSE PROTEIN FRACTIONS
… washing. Response surface methodology (Box Behnken design) was used to create mathematical models to explain quantitatively the relationship between treatment combinations (aqueous alcohol concentration, extraction temperature, extraction time) on the protein contents and yields of the …
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Exploitation of agricultural and forestry waste: from the recovery of bioactive compounds for nutraceutical applications to the production of innovative materials
… Response Surface Methodology (RSM) coupled with Box-Behnken design (BBD) models were adopted to optimize entirely eco-sustainable microwave-assisted extraction (MAE) protocols. The optimized shell extracts exhibited the highest total phenolic content (TPC) and antioxidant/antiradical activity. …
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Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
… for targeting breast cancer cells. Methods: Box-Behnken experimental design (BBD) was used to understand the effect of three independent factors (amount of liquid lipid, amount of drug and surfactant concentration) and interactions between these factors for each of the six liquid lipids on …
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Gas Chromatography: Mass Spectrometry of Chemical Agents and Related Interferents
One of the main problems encountered in chemical analysis operations in the field is collecting sufficient sample from the source and transferring that sample to the measurement instrument for fast separation and identification. I have been involved in developing a field-portable gas …
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