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Showing 1 to 20 of 78 for “"Borrelia burgdorferi"”.
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OspC in the pathogenesis of Borrelia burgdorferi
… a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial …
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Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
Borrelia spirochetes are the causative agents of Lyme disease and relapsing fever, two common vector-borne diseases. Early experimental evidence, gained from development of genetic tools in the Lyme disease spirochete, Borrelia burgdorferi, emphasized the importance of outer surface lipo-proteins …
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Regulatory networks of host defense against Borrelia burgdorferi
Contains fulltext : 207619.pdf (Publisher’s version ) (Open Access)
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Effektorfunktionen von Makrophagen nach Aktivierung mit Borrelia burgdorferi
… Entstehung der Resistenz gegenüber des Pathogens Borrelia burgdorferi eher durch das Fehlen einer Reaktion der Makrophagen des Wirtes als durch eine gezielte Antwort auf das Pathogen zustande kommt. Die hohe pro-inflammatorische Abwehrreaktion wäre somit für die Entstehung der verschiedenen …
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Characterization of P39, A <i>Borrelia burgdorferi</i> Specific Protein
<p><em>Borrelia burgdorferi</em>, the causative agent of Lyme disease, expresses a species specific, 39 kiloDalton protein of unknown function called P39. This protein is highly immunogenic and the presence of anti-P39 antibodies in patient sera is used as an indicator of B. burgdorferi infection. …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single …
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Immunological and Molecular Analyses of the Borrelia burgdorferi OspF Protein Family F
In North America, Borrelia burgdorferi is the primary causative agent of Lymedisease which is a growing health concern. The ability of B. burgdorferi to maintain chronic infection indicates that they are capable of immune evasion. A distinguishing characteristic of B. burgdorferi is the large …
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Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate …
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Geographic distributions and vertebrate host specificity of genetic lineages of Borrelia burgdorferi
… inform our understanding of host infection risk. Borrelia burgdorferi is a vector-borne bacterium that causes Lyme disease in humans and is common in the United States. The outer surface protein C (ospC) gene of B. burgdorferi exhibits substantial genetic variation across the pathogen’s …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated major outer surface proteins …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated major outer surface proteins …
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Investigation into peptidoglycan biosynthetic enzymes from the Lyme disease spirochete Borrelia burgdorferi
B. burgdorferi, the causative agent of Lyme disease, has unique chemical characteristics within its peptidoglycan (PG), such as the incorporation of L-Ornithine. This unusual structural feature may be implicated in immune evasion and may contribute to chronic symptoms such as Lyme arthritis and …
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Elucidating the role of peptidoglycan from Borrelia burgdorferi in Lyme disease pathogenesis
… bacterial cell wall from the causative agent, Borrelia burgdorferi, is a persistent antigen in Lyme arthritis patients, lingering within the synovial fluid. This antigen, peptidoglycan, is recognized by the immune system in numerous ways. Multiple publications have shown that peptidoglycan is …
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Osteoimmunological Characterization of Borrelia burgdorferi-Induced Bone Loss: From Phenotype to Molecular Mechanisms
… American region. The causative organism of LD, Borrelia burgdorferi (B. burgdorferi), is transmitted to the host (animals or humans) via the bite of Ixodes tick. B. burgdorferi is highly motile and disseminates to various tissues, including bone. B. burgdorferi induces trabecular long bone loss …
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Lyme disease in Indiana : isolation of Borrelia burgdorferi-like organisms from Dermacentor variabilis
… were examined for the etiological agent, Borrelia burgdorferi, of Lyme disease (LD), using dark-field and immunofluorescence microscopy, and tissue samples cultured in BSK II medium for 7 to 21 days. Spirochetes were isolated in the BSK II medium from pools of midgut diverticula from 6 D. …
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The Impact of Powassan Virus and Borrelia burgdorferi Coinfection in Ixodes scapularis Ticks
… include Powassan virus (POWV) and the spirochete Borrelia burgdorferi, both of which are transmitted by Ixodes scapularis in the northern parts of the United States. Powassan virus can lead to neuroinvasive illness with a high fatality rate. B. burgdorferi causes Lyme disease, a potentially …
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Ecology of Borrelia burgdorferi sensu lato and epidemiology of borrelial infections in Cumbria
Borrelia burgdorferi sensu lato (s.l.) is the causative agent of the tick-borne zoonotic disease Lyme borreliosis (LB), of which around 2-3000 cases are reported annually in the UK. This project took a “One Health” approach to studying Borrelia burgdorferi s.l. in southern Cumbria exploring its …
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Population and migratory dynamics of blacklegged ticks and the Lyme bacterium, Borrelia burgdorferi
… range expansion of ticks and the Lyme bacterium, Borrelia burgdorferi. These samples provide a unique opportunity to investigate the population dynamics and genetic structure of vectors and human pathogens as they expand into novel territory as well as the ability to characterize the degree to …
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