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Showing 1 to 20 of 104 for “"Borrelia"”.
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Characterization of cyclic di-GMP binding by the sole Borrelia burgdorferi and Borrelia hermsii PilZ domain-containing proteins
Borrelia burgdorferi and Borrelia hermsii cause Lyme disease and relapsing fever, respectively. These spirochetes are maintained in an enzootic cycle, involving tick vectors and mammalian hosts. Differential gene expression is central in their survival in various environmental conditions. C-di-GMP …
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Rates of Infection of Amblyomma Americanum and Dermacentor Variabilis By Borrelia Burgdorferi and Borrelia Lonestari in Southwest Missouri
Borrelia burgdorferi is the causative agent of Lyme disease and Borrelia lonestari was once the suspect agent of southern tick associated rash illness. Both are transmitted to human via the bite of an infected tick. The goal of this study was to investigate the prevalence of these Borrelia spp in …
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OspC in the pathogenesis of Borrelia burgdorferi
… a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial …
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Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
Borrelia spirochetes are the causative agents of Lyme disease and relapsing fever, two common vector-borne diseases. Early experimental evidence, gained from development of genetic tools in the Lyme disease spirochete, Borrelia burgdorferi, emphasized the importance of outer surface lipo-proteins …
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Cyclic-di-GMP Signaling in the Borrelia Spirochetes
… in 2008. The genome of its causative agent, Borrelia burgdorferi, encodes for a set of genes involved in the metabolism and regulatory activities of the second messenger nucleotide, cyclic-di-GMP (c-di-GMP). Rrp1 is a response regulatory-diguanylate cyclase, and its regulatory capability is …
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Regulatory networks of host defense against Borrelia burgdorferi
Contains fulltext : 207619.pdf (Publisher’s version ) (Open Access)
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Effektorfunktionen von Makrophagen nach Aktivierung mit Borrelia burgdorferi
… Entstehung der Resistenz gegenüber des Pathogens Borrelia burgdorferi eher durch das Fehlen einer Reaktion der Makrophagen des Wirtes als durch eine gezielte Antwort auf das Pathogen zustande kommt. Die hohe pro-inflammatorische Abwehrreaktion wäre somit für die Entstehung der verschiedenen …
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Characterization of Peptidoglycan, and the Enzymes that Synthesize it, in Borrelia burgdorferi and Insights into the Peptidoglycan of Other Pathogenic Borrelia
… — GlcNAc-GlcNAc-anhMurNAc (G-G- anhM) in Borrelia burgdorferi, the causative agent of Lyme disease. B. burgdorferi with less G-G-anhM were found to be significantly less motile, flexible, and stress-tolerant while possessing gross morphological defects and less overall PG. Our studies also …
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The Relapsing Fever Spirochete, Borrelia Hermsii, and Complement Regulatory Proteins
Borrelia hermsii, the primary etiological agent of tick-borne relapsing fever in North America, binds the complement regulatory protein factor H (FH) as a means of evading opsonophagocytosis and the alternative pathway of complement. The sequence of the gene encoding the FH-binding protein has been …
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Characterization of P39, A <i>Borrelia burgdorferi</i> Specific Protein
<p><em>Borrelia burgdorferi</em>, the causative agent of Lyme disease, expresses a species specific, 39 kiloDalton protein of unknown function called P39. This protein is highly immunogenic and the presence of anti-P39 antibodies in patient sera is used as an indicator of B. burgdorferi infection. …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single …
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Characterization of the Omega Subunit of Borrelia Burgdorferi’s RNA Polymerase
… insurance records. It is caused by the bacterium Borrelia burgdorferi which is transmitted by lxodes scapularis and lxodes pacificus across the United States. As B. burgdorferi cycles between tick to host, it encounters numerous environmental changes such as shifts in pH, organic acids, and …
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Immunological and Molecular Analyses of the Borrelia burgdorferi OspF Protein Family F
In North America, Borrelia burgdorferi is the primary causative agent of Lymedisease which is a growing health concern. The ability of B. burgdorferi to maintain chronic infection indicates that they are capable of immune evasion. A distinguishing characteristic of B. burgdorferi is the large …
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Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate …
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Geographic distributions and vertebrate host specificity of genetic lineages of Borrelia burgdorferi
… inform our understanding of host infection risk. Borrelia burgdorferi is a vector-borne bacterium that causes Lyme disease in humans and is common in the United States. The outer surface protein C (ospC) gene of B. burgdorferi exhibits substantial genetic variation across the pathogen’s …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated major outer surface proteins …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated major outer surface proteins …
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