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Showing 1 to 20 of 60 for “"Boronic Acids"”.
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Substituted Aryl Boronic Acids
Made available in DSpace on 2014-12-05T19:36:35Z (GMT). No. of bitstreams: 1 0020886.pdf: 5081472 bytes, checksum: 57b816180379bb08982e9109efe5dd0a (MD5) Previous issue date: 1957
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Nitrophenyl boronic acids as derivatizing agents in chromatography
… Samples of ortho, meta and para nitrophenyl boronic acids were prepared and purified, the purity of these products was examined by GC. The derivatization performance of these acids was studied employing a number of bifunctional model compounds such as: diols, aminoalcohols, hydroxy acids etc. …
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Saccharide recognition : boronic acids as receptors in polymeric networks
In this thesis entitled “Saccharide Recognition - Boronic acids as Receptors in Polymeric Networks” different aspects of boronic acid synthesis, their analysis and incorporation or attachment to different polymeric networks and characterisation thereof were investigated. The following key aspects …
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Shape-switching studies with cyclophanes and indicator displacement assays with boronic acids
… of indicator displacement assays (IDAs) with a boronic acid receptor, used for the differentiation of Z and E alkene mixtures. An IDA protocol was developed which is ammenable to high-throughput screening and can successfully identify Z and E alkene mixtures with an average absolute error of …
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
… diagnostics. Interest in peptides incorporating boronic acid moieties is increasing due to their potential as therapeutics/diagnostics for a variety of diseases such as cancer. The utility of peptide boronic acids may be expanded with access to vast libraries that can be deconvoluted rapidly and …
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Organic Transformations employing N-tosylhydrazones and boronic acids: stereoselective reductive couplings and cascade cyclizations
Las reacciones de acoplamiento cruzado libres de metal entre diazocompuestos o sulfonilhidrazonas y compuestos de organoboro presentan un gran potencial sintético. En la Introducción General de esta Memoria se recogen los avances pasados y recientes más significativos de la química relativa a este …
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Ligand design principles for perfecting stereoretention in Suzuki-Miyaura cross-coupling of unactivated CSP3 boronic acids
… reaction for unactivated secondary alkylboronic acids, it was critical to understand the competition between stereoretentive and stereoinvertive transmetalation mechanisms. Achieving perfect transfer of stereochemistry from building blocks to products required that one of these …
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1-Acylamido boronic acids and Difluoroborane analogs of amino acids: Synthesis and biological activity of transition state analogs for Chymotrypsin and Elastase (inhibition, esters)
"Several acylamido boronic acids and difluoroborane analogs of amino acids, some as single enantiomers, have been synthesized and evaluated as ""transition state"" inhibitors of the serine proteases (alpha)-chymotrypsin and elastase. These inhibitors were designed to resemble N-acyl phenylalanine, …
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Synthesis of α, β-Substituted Alkenylphosphonates from α-Phosphonovinyl Triflates: I) Palladium Catalyzed Suzuki-Miyaura Cross-coupling with Aryl Boronic Acids II) Palladium Catalyzed Reduction
… reaction of α-phosphonovinyl triflates and aryl boronic acids. The cross-coupling reactions were completed using simple reaction conditions, green solvents (isopropyl alcohol/H<sub>2</sub>O), a heterogeneous catalyst with a very low mole loading (0.007%), and a benign base. The 1-aryl-1-alkenyl …
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A kinetic investigation of boronic acid/diol interactions and pattern-based recognition of [alpha]-chiral carboxylates
Amine-functionalized boronic acids have revolutionized the field of carbohydrate sensing in recent years. Capable of rapidly and reversibly forming cyclic boronate esters with of 1,2- and 1,3-diols, polyols, catechols, and α-hydroxycarboxylic acids, boronic acids have found applications spanning …
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Iterative cross-coupling with MIDA boronates
… cross-coupling (ICC) of bifunctional haloboronic acid building blocks. Realizing a general ICC approach in the context of small molecule synthesis required the discovery of a ligand with the capacity to attenuate the reactivity of boronic acids under Suzuki-Miyaura cross-coupling (SMC) …
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Synthesis and biological evaluation of functionalized benzoxaboroles as potential antimicrobial agents
Boronic acids are extremely valuable compounds that have applications in medicinal, and materials chemistry, and also as cross-coupling agents in synthetic chemistry. Boronic acids often function as inhibitors for various enzymes due to their unique electronic and physicochemical properties. …
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One-Pot Synthesis of meta-Substituted Phenols via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling and Oxidation
… reaction between -chlorocyclohexenones with boronic acids, followed by aerobic oxidation of the resulting enone. This method is also suitable for the synthesis of meta- and ortho-disubstituted phenols, which have so far been especially difficult to access using existing synthetic methods. The …
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Catalytic and Biological Applications of Benzoxaborolones
Though first isolated 150 years ago, boronic acids have historically been neglected species. The more recent advent of transition metal-catalyzed reactions has led to an explosion in their use as building blocks, which in turn has led to their application in many other contexts as synthetic methods …
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Part I: synthesis and cross-coupling of the C1-C12 primary organoborane building block of amphotericin B; Part II: site- and stereoretentive cross-coupling of unactivated secondary boronic acids inspired by amphotericin B
… idealized limit, a collection of off-the-shelf boronic acid-based building blocks having all of the required functional groups pre-installed in the correct oxidation states and with the desired stereochemical relationships are readily assembled using only a single cross-coupling reaction …
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A synthesis of a homologous series of aryl mono- and diboronic acids
<p>Many attempts have been made to prepare aryl boronic acids and their esters which show a preferential affinity for tumor tissues for use in radiation therapy of neoplatic disorders (1,2). The data of Soloway, as extended and refined by Hansch and his coworkers, successfully correlates the low …
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Carbon-trifluoromethyl bond forming reactions and palladium-catalyzed cyanation of (hetero)aryl halides
… oxidative trifluoromethylation of (hetero)aryl boronic acids is reported. Bench top setup and visual reaction monitoring makes this process particularly well suited to medicinal and academic chemists. Fast reaction times allow for the trifluoromethylation of heterocyclic boronic acids that are …
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Slow-release cross-coupling and an advanced method for β-glycosylation: methods stimulated by amphotericin B
… MIDA boronates to act as surrogates for boronic acids. Additionally, conditions were identified under which MIDA boronates could be slowly hydrolyzed in the SMC reaction, enabling an in situ “slow-release” of the boronic acid. This slow release effect enables the efficient cross-coupling …
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Synthesis and Application of Boronic Acid Derivatives
Boronic acids are attractive synthetic intermediates and have been shown to be effective as inhibitors of various enzymes. In this project, the overarching goal is the selective inhibition of a protease present in the mitochondria known as human ClpXP. To study the potential selective inhibition of …
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Asymmetric nickel-catalyzed three-component assembly of allylic amines from alkynes, imines and organoboron reagents
… from alkynes, imines, and organoboron reagents (boronic acids or boranes) using a catalyst derived from Ni(cod)2 and (c-CsH9)3P or (o-anisyl)3P. This catalytic, three-component process is tolerant of ketones, esters, and free hydroxyl groups; a degree of functional group compatibility unusual for …
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