Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Bordetella pertussis"”.
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Antigenic modulation in Bordetella pertussis
Summary available: p. ii.
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Genetic studies with Bordetella pertussis
Summary available: p.18
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Modulation of Bordetella pertussis by nicotinic acid
Summary available: p. i-iii
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Comparative proteomic analysis of Australian epidemic Bordetella pertussis
Bordetella pertussis causes whooping cough, a re-emerging vaccine preventable disease. Pathogen adaptation is an important factor for re-emergence. Since acellular vaccine (ACV) introduction, the predominant strains changed to single nucleotide polymorphism (SNP) cluster I (ptxP3/prn2) from cluster …
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Characterisation and secretion mechanism of Bordetella pertussis autotransporter proteins
… of new virulence determinants of 5. pertussis is providing important information for understanding the colonisation and survival strategies of the microorganism. B. pertussis deploys a range of surface-associated components to enable its successful colonisation of the host. Bap-5 has …
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Global dynamics of Bordetella pertussis and implications for control
*Bordetella pertussis* is the main cause of whooping cough, a disease that still infects millions of individuals annually despite widespread vaccination. This is particularly problematic in neonates, where infection can lead to death. Endemicity, subclinical infections and circulation of multiple …
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Tex aus Bordetella pertussis definiert eine neue Familie von Nukleinsäure-Bindeproteinen
Das Tex Protein aus Bordetella pertussis definiert eine neue Familie hoch konservierter Proteine in Eubakterien. Ursprünglich wurde das tex Gen aufgrund seines Einflusses auf die Toxinexpression in bestimmten regulatorischen Mutanten von B. pertussis gefunden (Fuchs et al. (1996), J Bacteriol 178, …
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Genetic analysis and characterisation of the BapC autotransporter of bordetella pertussis
… to have a similar mechanism of export. In B. pertussis, the virulence-regulated proteins Pertactin, BrkA, Tcf, and Vag8 have structural homology at their C-termini (30-kDa) and the N-terminal of the mature proteins share structural characteristics such as RGD and SGXG motifs. Recently, another …
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Decoding mucosal immunity: Impact of SARS-CoV-2 and Bordetella pertussis vaccination and infection
Contains fulltext : 319744.pdf (Publisher’s version ) (Open Access)
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Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
… of protective efficacy. Traditionally whole cell pertussis vaccines (Pw) have been controlled using the Kendrick test, which measures protection following intracerebral challenge with Bordetella pertussis. However, this test is unsuitable for assessing the potency o f the new acellular pertussis …
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Characterization of the Aspartate Transcarbamoylase that is Found in the pyrBC" Complex of Bordetella Pertussis
An aspartate transcarbamoylase (ATCase) gene from Bordetella pertussis was amplified by PCR and ligated into pT-ADV for expression in Escherichia coli. This particular ATCase (pyrB) was an inactive gene found adjacent to an inactive dihydroorotase (DHOase) gene (pyrC'). This experiment was …
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Molecular studies into the causes of the resurgence of Bordetella pertussis in the face of vaccination
Contains fulltext : 105820.pdf (Publisher’s version ) (Open Access)
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An Examination of the Function and the Transcriptional Regulation of the Bps Polysaccharide in Bordetella pertussis Pathogenesis and Biofilm Development
Most bacterial species are capable of existing as surface-adhered communities encased in a matrix called biofilms. These aggregates of sessile bacteria are increasingly being associated with multiple human infections. However, the bacterial factors that contribute to biofilm formation are poorly …
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Pertussis: Advances in Vaccine Development and Disease Control Strategies
Pertussis, also known as whooping cough, caused by Bordetella pertussis, remains a significant public health challenge despite widespread vaccination programs. This thesis explores advancements in vaccine development and disease control strategies. It emphasizes virulence factors such as Vag8, …
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Epidemiology of pertussis in children hospitalised with respiratory tract infection
The availability of an effective vaccine against Bordetella pertussis substantially reduced the morbidity and mortality from pertussis, however, in the last decade there appears to have been a substantial increase in pertussis cases as reported mainly in high income countries. Although it is …
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Epidemiology of pertussis in children hospitalised with respiratory tract infection
The availability of an effective vaccine against Bordetella pertussis substantially reduced the morbidity and mortality from pertussis, however, in the last decade there appears to have been a substantial increase in pertussis cases as reported mainly in high income countries. Although it is …
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The performance of respiratory illness surveillance case definitions to detect Bordetella pertussis in children aged < 5 years seeking healthcare for respiratory illness in South Africa, 2017-2023
Background: Pertussis is vaccine‐preventable and requires surveillance to guide interventions. Assessing the performance of syndromic surveillance and the World Health Organization (WHO) pertussis case definitions can improve sensitivity and accuracy in detecting laboratory‐confirmed Bordetella …
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The impact of myeloid derived suppressor cells on vaccine immunogenicity in South African HIV-infected and uninfected mothers and their infants
… we measured BCG, Hepatitis B, Tetanus toxoid and Bordetella pertussis vaccine-specific CD4+ T cell proliferation by CFSE and IFN-γ responses using ELISpot assay.
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Characterization of The Role of The Pkm101-Encoded T4Ss Outer Membrane Core Complex In Substrate Transfer, Pilus Biogenesis, and Recipient Cell Contact
… Trw<sub>R388</sub>, or the Ptl T4SS of <em>Bordetella pertussis</em> restoring recipient cell contact and plasmid transfer. These results highlight the common ancestry between these functionally distinct machines and support a model where functionally independent IMCs and OMCCs have …
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