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Showing 1 to 2 of 2 for “"Bootlegger"”.
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Determinants of piRNA precursor transcription and export in Drosophila melanogaster
… Nxf3. Nxf3 is recruited to piRNA clusters by Bootlegger, a novel piRNA factor characterised in this work. Nxf3 specifically binds piRNA cluster transcripts and is responsible for their export to peri-nuclear processing sites via a Crm1-dependent mechanism. This work uncovers a specialised …
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Evolutionary conservation of unistrand piRNA clusters and characterisation of the piRNA precursor export machinery in Drosophila
… Nxf3, its co-factor Nxt1, and the orphan protein Bootlegger (Boot). Through interaction studies, I established that Boot and Nxf3 are multivalent interaction partners. Orthogonally, XL-MS data indicates that there are interacting residues between these two proteins throughout their entire protein …