Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Boolean network"”.
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Synthesising executable gene regulatory networks in haematopoiesis from single-cell gene expression data
… is to understand the complex gene regulatory networks which control tissue development in the mammalian embryo, and maintain homoeostasis in the adult. The cell fate decisions underlying these processes are ultimately made at the level of individual cells. Recent experimental advances in …
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The role of criticality of gene regulatory networks on emergent properties of biological systems
… between criticality of gene regulatory networks (GRNs) and dynamics of GRNs at a single cell level has been vigorously studied. However, the relationship between the criticality of GRNs and properties of multicellular organisms at a higher level has not been fully explored. Here we aim …
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Mapping Genotype to Phenotype using Attribute Grammar
… of synthetic biology to model genetic regulatory networks with Ordinary Differential Equations (ODEs) based on various rate laws or with discrete boolean network models. We implemented a demonstration of these concepts in GenoCAD, a Computer Assisted Design (CAD) software for synthetic biology. …
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On stability and controllability of conjunctive Boolean networks
A Boolean network (BN) is a finite state discrete time dynamical system. At each step, each variable takes a value from a binary set. The value update rule for each variable is a local function which depends only on a selected subset of variables. BNs have been used in modeling gene regulatory …
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A Complex Systems Approach to Understanding Cells as Systems and Agents
… in a controlled setting. In this work, I utilize Boolean network (BN) models to investigate cells, the fundamental units of life, as both systems of intracellular components and the agents that interact within cellular populations. Specifically, I simulate cell-like agents composed of networks …
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Mapping the transcriptional landscape of haematopoietic stem and progenitor cells
… single-cell level and are governed by regulatory networks. Dysregulation in this balanced process could lead to serious blood disorders such as leukaemia; therefore, it is important to understand how individual cells make these cell-fate decisions. To investigate HSPC populations, 1,654 cells were …
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Robustness Analysis of Gene Regulatory Networks
… First, the special topology of gene regulatory networks (GRNs) seems to be an important factor as they possess feedforward loops and certain other topological features much more frequently than expected. Second, genes often regulate each other in a canalizing fashion: there exists a dominance …
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Creation and enhancement of a quantized hybrid computational model of cell cycle progression including DNA damage and repair mechanisms
… depending on the desired result with continuous, Boolean and hybrid models all used to investigate cellular processes. <br/><br/>This thesis presents a computational model of cell cycle progression controlled by the cyclin proteins, and ultimately the genes that regulate their expression. This …
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Systems evolution: the conceptual framework and a formal model
… "Hypercycle", "Cellular Automata", "Random Boolean Network" et al., a general conceptual framework for systems evolution has been outlined and it is based on the concept of emergent attractor for open systems. The emphasis is placed on the structural aspect of the process of change. Modem …