Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Bone scaffolds"”.
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3D printing of bone scaffolds using powders derived from biogenic sources
This doctoral work was developed in the frame of bone tissue engineering, dealing with the fabrication of scaffolds for the regeneration of bones. At this purpose, calcium phosphates derived from natural sources are very interesting because they are more similar to the bone mineral and possess …
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Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds
… demonstrates that (1) the design of synthetic bone scaffolds should include controlled multi-scale porosity to promote multi-scale osteointegration, which may significantly improve scaffold mechanical properties and (2) human umbilical cord blood-derived endothelial colony forming cells have …
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Microstructure-induced capillary force effects on penetration and release in hydroxyapatite bone scaffolds
Ceramic bone scaffolds with both microporosity (<50µm) and macroporosity (>100µm) are known to enhance bone formation. Including microporosity in a scaffold increases bone volume and distribution. The integration of the bone with the scaffold is also improved as both cells and mineralized bone have …
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Development of Model Hydroxyapatite Bone Scaffolds With Multiscale Porosity for Potential Load Bearing Applications
… microporous topography alone did not influence bone healing in vivo, micropores were shown to provide tailorability of scaffold mechanical properties, provide a location for the storage and controlled release of a growth factor, and provide a location for bone integration inside the scaffold …
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Quantitative image analysis of in vivo microstructure and growth factor effects in hydroxyapatite bone scaffolds
… agents, such as BMP-2, are known to improve bone formation when combined with scaffolds. Microporosity (<20µm) has also been shown to influence bone regeneration in calcium phosphate (CaP) scaffolds. However, many studies use only the term “osteoconductive” to describe the effects of BMP-2 …
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Modeling and control of an easy-to-use direct write printing system for fabrication of bone scaffolds
This Thesis was approved for publication on 2017-07-21 at 08:17.
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Additive manufacturing of stiffness optimised auxetic bone scaffold using cobalt-chromium-molybdenum superalloy
… tissue engineering constructs, such as bone scaffolds for critical-size defects. Emerging early-stage studies have shown the potential of auxetic architecture in increasing cell proliferation and tissue reintegration due to their −𝜐. However, research on the development of stiffness …
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Osteoblast Response to Zirconia-Hybridized Pyrophosphate Stabilized Amorphous Calcium Phosphate
… acid) (PLGA), have been used to fabricate porous bone scaffolds to support bone tissue development. These scaffolds allow for cell seeding, attachment, growth and extracellular matrix production in vitro and are replaced by new bone tissue when implanted into bone sites in vivo. Hydroxyapatite …
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Macro- and micro-structural features direct bone regeneration in patterned biphasic calcium phosphate scaffolds
The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate …
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Ovalbumin-Based Scaffolds Reinforced with Cellulose Nanocrystals for Bone Tissue Engineering
… engineering, a major area of study is developing bone scaffolds that will provide support for osteoblasts. Despite many advances in recent years there is still a significant need for new bio-based 3-D porous scaffolds that possess sufficient initial mechanical properties to prevent immediate …
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Additive manufacturing of triply periodic minimal surface informed load bearing stiffness matched tibial bone scaffold
… thesis investigates the development of titanium scaffolds based on Triply Periodic Minimal Surface (TPMS) structures to create bone implants that effectively match the mechanical properties of the tibia. The primary goal is to design and fabricate titanium (Ti6Al4V) scaffolds that provide optimal …
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Long-term osteointegration of BMP-2 eluting hydroxyapatite scaffolds for bone tissue engineering
… and tumor resections can result in discontinuity bone defects, which are typically treated through bone grafting. Potential limitations, such as donor site morbidity, make the development of synthetic implants with similar success to current techniques an attractive alternative for the repair of …
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Development of High Strength Dicalcium Phosphate Anhydrous Cement with Nanosilica Sol
… based materials have large potential as bone repair substitutes and drug delivery systems due to high bioactivity and known solubility in body fluid, and they could provide useful scaffolds in tissue engineering and orthopedic applications. Clinicians increasingly need bone scaffolds to …
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Synthesis and Characterization of Novel Polyester Scaffolds from Sugarcane Industry By-products for Use in Skin and Bone Tissue Engineering
… from by-products of the sugarcane industry as scaffolds for skin and bone tissue engineering. Utilizing the by-products, molasses and sugarcane bagasse, not only add value to the cane industry, but also paves path for synthesizing novel bio-based materials from the isolated specialty chemicals. …
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Flexible adaptation of iterative learning control with applications to synthetic bone graft manufacturing
… in fabricating advanced architecture synthetic bone grafts. These bone grafts, also known as synthetic bone scaffolds, are highly porous three-dimensional structures that provide a matrix to support the natural process of bone remodeling. Ideally, the synthetic scaffold will stimulate complete …
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Biomedical Applications of Thiol-Acrylate Polymers
… to the polymeric phase and foaming, a porous bone composite was produced. Further osteogenisis and in vivo work using the PETA-co-TMPTMP (HA) composite material was analyzed. The PETA-co-TMPTMP-co-TMTMP with 20%HA showed an increase in osteogenic potential higher than the FDA approved PCL over …
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Bioactive Cellulose Nanocrystal Reinforced 3D Printable Poly(epsilon-caprolactone) Nanocomposite for Bone Tissue Engineering
Polymeric bone scaffolds are a promising tissue engineering approach for the repair of critical-size bone defects. Porous three-dimensional (3D) scaffolds play an essential role as templates to guide new tissue formation. However, there are critical challenges arising from the poor mechanical …
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Characterization of human adipose tissue-derived adult multipotent precursor cells
… induction studies, ADSC were able to express bone characteristics which were then confirmed in an in vivo model. This work progressed to the identification of candidate genes involved in differentiation of ADSCs. Using microarray technologies, genes of relevance to the osteogenic …