Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Bone morphogenetic protein 2 (BMP-2)"”.
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Differentielle Genexpression bei der Membranösen Glomerulonephritis und die Rolle des 'bone morphogenetic protein 2' für die Funktion des Podozyten
… einer Schädigung des Podozyten mit nachfolgender Proteinurie kommt. Unklar ist, welche zellulären Mechanismen zu der anhaltenden Funktionsstörung des Podozyten führen. Die Ergebnisse der vorliegenden Arbeit lassen sich wie folgt zusammenfassen:<br>Mit Hilfe von cDNA-Expressions-Analysen konnte die …
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Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions
… focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer (LbL) deposition platform was used to fabricate conformal, tunable, micron scale …
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Klonierung, Expression und Charakterisierung von Mutanten des Bone Morphogenetic Protein-2
Das Zytokin Bone Morphogenetic Protein-2 (BMP-2) gehört als Mitglied der Transforming Growth Factor ß-Superfamilie zu einer großen Gruppe eng verwandter Wachstums- und Differenzierungsfaktoren. Es spielt eine entscheidende Rolle bei Bildung und Regeneration von Knorpel und Knochen und während …
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Adeno-Associated Virus-Based Gene Delivery Approaches for Tissue Engineering
… Optogenetic tools based on light-sensitive proteins offer an exquisite option for fine-tuning expression levels with minimal interference and at low cost. Adeno-associated virus (AAV) is employed as the candidate gene delivery vehicle due to its ability to infect many cell types and good …
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Synthetic Hydrogel Delivery of Growth Factors and Demineralized Bone Matrix for Bone Augmentation
… delivery of growth factors and demineralized bone matrix (DBM) for bone augmentation. Our motivation rests on observed weaknesses of current clinical approaches to bone augmentation, which synthetic hydrogels hope to overcome based on non-invasive application, contouring, tunability, and drug …
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Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
The treatment of craniomaxillofacial bone defects with drug-eluting synthetic implants is a promising treatment currently being investigated. It is becoming increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… between cartilage and the underlying subchondral bone, linking the pathogenesis/regeneration of both tissues. Thus, this thesis seeks to develop hydrogel composites as growth factor and cell delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the release of …
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Βιοχημικοί και ιστοπαθολογικοί δείκτες εκτίμησης αποτελεσματικότητας σύγχρονων θεραπευτικών προσεγγίσεων οστεοπόρωσης
… ανοσοϊστοχημική χρώση των μορίων Bone Morphogenetic Protein-2 (BMP-2) και Fas (παράγοντας οστεοκλαστικής απόπτωσης) σε τομές σε πλαστικό, καθώς και ανοσοαποτύπωση κατά Western των αυτών πρωτεϊνών. Γενικά, όλες οι μέθοδοι που εφαρμόστηκαν, έδειξαν να ακολουθούν όλες τις μεταβολές …
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Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
External stresses surrounding bone can stimulate heat shock proteins (HSPs), which are involved in anti-apoptosis, cell proliferation, and differentiation. In vitro stress modulation and HSP induction may be critical factors for enhancing bone regeneration. We investigated whether applying …
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Knochenneubildung durch induktive Implantate der TGF-Beta-Familie : eine tierexperimentelle Studie zum Synergismus von BMP-2-Mutanten und TGF-Beta bei der heterotopen Osteoinduktion
Die osteoinduktive Wirkung von „Bone morphogenetic protein 2“ (BMP-2) und der regulative Einfluss des Faktors „Transforming growth factor beta 1“ auf das physiologische Remodelling des Knochens sind durch zahlreiche In-vitro- und In-vivo-Untersuchungen belegt. Die gentechnische Modifikation der …
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Chondrogenic capacities of equine synovial progenitor populations
… more appropriate source than MSCs isolated from bone marrow. To compare the chondrogenic capacities of MSCs isolated from equine synovium (SYN), bone marrow (BM) and adipose (FAT) tissue, six healthy adult horses were used in this study. BM aspirates were collected from tuber coxae, SYN tissues …
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Quantitative image analysis of in vivo microstructure and growth factor effects in hydroxyapatite bone scaffolds
Osteoinductive agents, such as BMP-2, are known to improve bone formation when combined with scaffolds. Microporosity (<20µm) has also been shown to influence bone regeneration in calcium phosphate (CaP) scaffolds. However, many studies use only the term “osteoconductive” to describe the effects of …
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Driving tissue morphogenetic cascades using tunable nanolayered surface coatings
… and congenital defects that result in large bone tissue defects are often corrected with autograft bone, which results in the matching of native bone tissue properties. However, the limited availability of donor bone coupled with pain at the site renders autografting suboptimal therapy. …