Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Bone morphogenetic protein (BMP) signalling"”.
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The Role of Bone Morphogenetic Protein (BMP) Signalling in Lung Cancer and Lung Regeneration
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta (TGFβ) super-family of signalling molecules. BMPs play crucial roles in developing and adult tissues during processes including proliferation, differentiation, apoptosis and epithelial-mesenchymal transition …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
Bone morphogenetic protein (BMP) signalling is essential for correct lung development where it mediates lung branching morphogenesis. In the adult lung, the BMP pathway is activated during airway inflammation. However, a role for activated BMP signalling has not yet been elucidated. The aims of …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
Bone morphogenetic protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… vivo. KLF4 promotes an endogenous production of bone morphogenetic protein 6 (BMP6) in ECs that, in turn, activates the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling pathway. KLF4 transcriptional activity and KLF4-dependent TGF-β/BMP pathway activation are …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
Bone morphogenetic protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in the establishment of correct epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is …
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Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
… the role of miRNAs in mediating the effects of BMP signalling in the skin. To address Aims 1 & 2, global miRNA expression profiling in the skin was performed and revealed marked changes in miRNAs expression during distinct stages of the murine hair cycle. Specifically, miR-31 markedly increased …