Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Bone morphogenetic protein"”.
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
Bone morphogenetic protein (BMP) signalling is essential for correct lung development where it mediates lung branching morphogenesis. In the adult lung, the BMP pathway is activated during airway inflammation. However, a role for activated BMP signalling has not yet been elucidated. The aims of …
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Klonierung, Expression und Charakterisierung von Mutanten des Bone Morphogenetic Protein-2
Das Zytokin Bone Morphogenetic Protein-2 (BMP-2) gehört als Mitglied der Transforming Growth Factor ß-Superfamilie zu einer großen Gruppe eng verwandter Wachstums- und Differenzierungsfaktoren. Es spielt eine entscheidende Rolle bei Bildung und Regeneration von Knorpel und Knochen und während …
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Strategies to Target the Bone Morphogenetic Protein Signalling Pathway in Lung Disease
Lung disease and lung injury are responsible for 20% of deaths of the Irish population every year, and the country has the 2nd highest death rate in Europe for respiratory diseases. Conditions related to the respiratory system are the second largest long term illness by young adults. Lung cancer is …
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Bone morphogenetic protein (BMP-7) και μοριακά δίκτυα δυνητικών stem κυττάρων στον νεφρό
Η BMP-7 αποτελεί μόριο κλειδί κατά την εμβρυογένεση στον νεφρό, ενώ μετέπειτα, θεωρείται νεφροπροστατευτικός παράγων. Ο νεφρός χαρακτηρίζεται από μία μοναδική πλαστικότητα μεταξύ επιθηλιακών και μεσεγχυματικών κυττάρων. Κατά την ανάπτυξη του Νεφρού, το επιθήλιο του νεφρώνα δημιουργείται μέσω της …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in the establishment of correct epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is …
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The Role of Bone Morphogenetic Protein (BMP) Signalling in Lung Cancer and Lung Regeneration
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta (TGFβ) super-family of signalling molecules. BMPs play crucial roles in developing and adult tissues during processes including proliferation, differentiation, apoptosis and epithelial-mesenchymal transition …
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
… is principally transcriptional, where the Bone Morphogenetic Protein (BMP) pathway has been shown to be a major network governing hepcidin expression. The current study utilised the HPX mouse model to identify potential regulators of hepcidin that are produced locally in liver with a focus …
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Die Wiederherstellung der Unterkieferkontinuität mittels rhBMP-2 (Recombinant Human Bone Morphogenetic Protein-2) nach ausgedehnten Resektionen im Minischwein
… kollagenen Träger (ICBM, insoluble collagenous bone matrix) rekonstruiert. Bei der zweiten Hälfte wurde dieser Träger zunächst in eine Muskeltasche des M. latissimus dorsi heterotop implantiert. Der neugebildete Knochen wurde nach acht Wochen zur Rekonstruktion in den Unterkiefer transplantiert. …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… SCI in rats, we found that the active form of bone morphogenetic protein-4 (BMP4) is transiently and acutely upregulated after injury. BMP4 is a key signaling protein that regulates embryogenesis and neurodevelopment. BMP4 has also been implicated in modulating glial scarring and remyelination …
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Healing of Bone Fracture in Type 1 Diabetic Rat Models: a Potential Gene Therapy Using Bone Morphogenetic Protein
… the impaired healing procedure after fracture. Bone morphogenetic proteins are well-known for their osteoinductive functions. BMP-6, which is a newly-discovered member to the BMP family, has been reported to show potent bone-forming effects and take active part in glucose metabolism. Although …
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Differentielle Genexpression bei der Membranösen Glomerulonephritis und die Rolle des 'bone morphogenetic protein 2' für die Funktion des Podozyten
… einer Schädigung des Podozyten mit nachfolgender Proteinurie kommt. Unklar ist, welche zellulären Mechanismen zu der anhaltenden Funktionsstörung des Podozyten führen. Die Ergebnisse der vorliegenden Arbeit lassen sich wie folgt zusammenfassen:<br>Mit Hilfe von cDNA-Expressions-Analysen konnte die …
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An Investigative Study Into the Relationship of Bone Morphogenetic Protein Antagonist Expression and Osteocyte Density by Region and Quadrant
… and cell behavior and viability with respect to bone remodeling and bone behavior is an exciting area of orthopedic research. The purpose of this study was to investigate the relationships between BMP antagonist expression and osteocyte density, lacunar densities and osteocyte viability in …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
… mutations in BMPR2, the gene encoding the bone morphogenetic protein (BMP) type II receptor (BMPR-II). The endothelial-selective BMPR-II ligand, BMP9, has been shown to reverse disease in animal models of PAH and suppress the proliferation of healthy endothelial cells. However, the impact …
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Rekombinantes humanes Bone-Morphogenetic-Protein-7 (rhBMP-7, rhOP-1) ermöglicht die transpedikuläre interkorporelle Spondylodese an der Lendenwirbelsäule des Schafes
EINFÜHRUNG: Bisherige Methoden der Behandlung von Wirbelkörperfrakturen machten ein kombiniertes Vorgehen aus anteriorem und posteriorem Zugang zum frakturierten Wirbelkörper erforderlich, um zwei Dinge zu ermöglichen: die Stabilisierung der hinteren Säule durch einen Fixateur interne und die …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… activity, reduce the phosphorylation of SMAD3 proteins, and decrease the expression of pai-1 transcript. These green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 mitogen-activated protein kinase proteins and promoted BMP4-induced SMAD-dependent by increasing the …
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Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
… (TGN) and plasma membrane (PM) is vital for protein secretion and growth factor signaling, which involves recycling and PM localization of cell surface receptors. These processes depend on the cytoskeleton and the presence of phosphoinositide (PI) species in specific intracellular …
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The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin.
Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) coordinate tissue development and postnatal remodelling by regulating proliferation, differentiation and apoptosis. However, their role in wound healing remains unclear. To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
Bone morphogenetic protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of …
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Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… mesoderm, endoderm, and ectoderm are specified. Bone morphogenetic protein 4 (BMP4), secreted from the extraembryonic ectoderm is required for gastrulation to start whereby it activates downstream signaling molecules wingless inhibitor 3 (WNT3) and Nodal in a concentration dependent manner to …
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Developing a Caenorhabditis elegans Model for Marfan Syndrome
… gene, which encodes an extracellular matrix glycoprotein, and is required for proper cardiac and skeletal development and for sequestration of TGFβ (transforming growth factor beta) and BMP (bone morphogenetic protein) within the extracellular matrix (ECM). The primary objective of this study was …
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