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Showing 1 to 10 of 10 for “"Bone marrow stromal cell"”.
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
<p> Over the years, the repair of bone defect is an increasing challenge for reconstructive surgery. Due to disadvantage of autograft and allograft, including limit of bone supply, high morbidity and potential immune response, synthetic scaffold have been studied as a promising strategy for tissue …
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Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. They have cited enthusiasm in the cell therapy community not only for their …
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Dietary regulation of myelopoiesis and stromal cell isolation
… chloride did not alter monocyte, granulocyte, T cell, B cell, or NK cell distributions in blood. In spleen, 10% sodium chloride did reduce the presence of NK cells but had minimal effect on other cell populations. In bone marrow, 10% sodium chloride increased the presence of T cells and both …
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Bst2 Isoforms: Distribution and Potential Use In Cancer Therapeutics
<p>Identifying a cancer-specific cellular target is one of the key factors that can pave a “bench to the bedside” path of a target therapy. Bone marrow stromal cell antigen 2 (BST2) is a raft-associated type II transmembrane protein with an unusual topology. Analyses showed a variable degree of …
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Supporting bone regeneration: Evaluation of endocrine peptides and delivery systems for local application of lactoferrin
… outcomes. Delivery systems that can enhance bone formation, accelerate regeneration and healing, and ultimately restore bone integrity and strength, are still largely missing. Aim We aimed to evaluate the myokine irisin and the neuropeptide orexin as potential bone anabolic factors and to …
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GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… of TKIs in eradication of leukemic stem cells (LSCs). Accumulating evidence demonstrates that bone marrow stromal cell secreting factors, such as Interleukin 3 (IL3) hinder TKI activity and support CML–LSCs to survive the therapy with innate drug resistance. Therefore, the overall …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
… popularly used either as temporary scaffolds for cell transplantation to regenerate tissues or as drug carriers for delivery of bioactive molecules. Our laboratory has done researches in developing hydrogel scaffolds for bone regeneration for over 5 years, including PLGA polymer synthesis and …
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Engineered N-cadherin substrates for stem cell differentiation
… made to modulate neural differentiation of stem cells using soluble factors and cell adhesion matrix properties. These differentiation studies are often dependent on the density of cells plated on the substrate, which implies that there is an important role of cadherin-modulated cell-cell …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… nerve fibres. While several studies suggest the bone-catabolic nature of noradrenergic innervation in decreasing osteoblast activity and promoting osteoclastogenesis, there is little known on the development and function of skeletal cholinergic innervation. Therefore, the first goal of my …
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In-vitro Modelling of Stromal and Immune Cell Interactions Following Surgical Bone Marrow Stimulation
… (OA) results in degeneration of cartilage and bone within a joint, leading to pain and loss-of-function. While effective treatments exist for end-stage OA, earlier disease stages lack treatment options. Micro-fracture and micro-drilling, often termed bone marrow stimulation techniques, offer an …