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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Bone marrow mesenchymal stem cells"”.
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The Regulation of Bone Marrow Mesenchymal Stem Cells by Vascular Cell Adhesion Molecule-1
Bone marrow (BM) mesenchymal stem cells (MSCs) form specialized perivascular microenvironments or niches in the BM that regulate hematopoietic stem cell (HSC) function. Interactions between MSC niche factors and HSCs ensure hematopoietic homeostasis. Vascular Cell Adhesion Molecule-1 (VCAM1) is …
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Homing of 111In-Labeled Bone Marrow Mesenchymal Stem Cells in Acute Brain Trauma Model
… vivo distribution of intravenously transplanted bone marrow-derived mesenchymal stem cells (BMSCs) in an acute brain trauma model by 111In-tropolone labeling and to perform the effect of 111In-labeling on the viability and functions of BMSCs. Rat BMSCs were labeled with 37 MBq 111In-tropolone. …
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Comparison of bone marrow mesenchymal stem cells and tendon progenitor cells cultured on collagen surfaces
… of the tissue, low number of resident progenitor cells, and healing under weight-bearing conditions. Strategies to improve tendon healing have focused on enhancing the metabolic response of tenocytes, modulating the organization of the newly synthesized extracellular matrix, or administering …
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Optimization of culture conditions for equine bone marrow mesenchymal stem cells and their differentiation into osteoblasts
… the animals is of great focus for horse owners. Bone fractures are an aspect of equine health failure that is continually catastrophic and often fatal. In addition to discussing fracture, this review will outline the process by which bone tissue is regularly maintained and self-healed. Also, …
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Effect of platelet factors and thrombin on multiplication of human bone marrow mesenchymal stem cells cultured in low and high oxygen level in vitro
<p>Background: In the bone marrow, hematopoietic and mesenchymal stem cells form a unique niche, in which oxygen tension is low. Hypoxia may have a role in maintaining stem cell capacity for self-renewal and multipotency. We have shown previously a positive influence of platelet-derived growth …
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3D BIO-PRINTED SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATION: AN INVIVO EVALUATION WITH FURTHER OPTIMIZATION
… in subjects where the scaffold was seeded with bone marrow mesenchymal stem cells. No significant foreign body reaction was found. Scaffold extrusion and flattening was noticed in some subjects. Combining the scaffold with a Poly(ethylene) Glycol – Fibrinogen (PF) Hydrogel preliminarily improved …
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Gingival MSCs Improve Bone Phenotype in Ovariectomy-Induced Osteoporosis via Programmed Cell Death Pathway
… deficiency-related osteoporosis is a skeletal system disorder that affects women after menopause taking a toll on financial and health institutions. Gingival Mesenchymal Stem cells (GMSCs) are a distinctive population of dental tissue-derived stem cells that possess uniquely high proliferation …
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Discovery of novel anti-inflammatory proteins inspired by bone marrow mesenchymal stem cell secretions
Bone marrow mesenchymal stem cells (MSCs) may soon become the first FDA-approved stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may be attributed to molecules secreted by these cells. This thesis will test …
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INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION
… in treating complicated wound with exposed bone (Wijewardena et al. 2011, DeFranzo et al. 2001). However, NPWT is not established as a treatment modality for orthopedic application and its mechanistic pathways of action on cellular activities is unknown. To support proper bone healing, the …
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The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… is known to have effects on digestive system, cardiovascular system, and kidney function. The authors studied the effects of ethyl acetate extract of poncirus trifoliata on the activities of osteoblast and animal model. Effects of osteoblastic differentiation were measured by alkaline …
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Making In Utero Gene Therapy Safer and More Efficient: A First Step Towards Clinical Realization
… safety of viral vectors. A two-vector delivery system was constructed to perform cell-specific in utero gene therapy, and I showed proof-of-principle that the system functions in vitro in human and sheep cells. An Ad5 serotype adenoviral vector (Ad5) acts as the first delivery-vehicle, which …
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Tracking of Transplanted Mesenchymal Stem Cells Labeled with Fluorescent Magnetic Nanoparticle in Liver Cirrhosis Rat Model with 3T MRI
… the therapeutic effect of transplantation of bone marrow stem cells. In vivo visualization of transplanted stem cells with noninvasive technique is essential for the monitoring of cell implantation, homing and differentiation. This study was designed to track intrasplenically injected bone …
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Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
In acute myeloid leukaemia (AML), malignant cells surviving chemotherapy rely on high mRNA translation and their microenvironmental metabolic support to drive relapse. However, the role of translational reprogramming in the niche was, until now, unclear. This study found that relapsing AML cells …