Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Bone healing"”.
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Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
… but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in …
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SURFACE MODIFICATION OF TITANIUM AND TITANIUM ALLOYS TO ENHANCE BONE HEALING
… ability to osseointegrate with the surrounding bone. In order to improve the bioactivity and osseointegration of titanium implants, especially in compromised bone, surface modification of the implant surface and surface coatings have been introduced. There are different kinds of surface …
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AGING OF MUSCLE-TENDON UNITS INFLUENCES COMMON ORTHOPAEDIC INJURIES AND TENDON-TO-BONE HEALING
<bold>Introduction:</bold>
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Stimulation of bone healing in new fractures of the tibial shaft using interferential currents
… out if interferential currents could reduce the healing time for fractures of the tibia and thereby prevent nonunion and secondly to develop a model which could predict nonunion, given the subject characteristics such as race, mechanism of injury, severity of fracture etc. Subjects, males only …
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Canine mandibular osteotomy model: the effects of fixation on bone healing and nerve regeneration
… the mandible were stabilized with monocortical bone plate (n = 6), interdental (n = 6), and external skeletal fixation (n = 6). None of the dogs showed clinical evidence of pain or discomfort associated with the fixation devices or the development of neuromas. Radiographic signs of bone healing …
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Effects of Electrically-Stimulated Silver-Coated Implants and Bacterial Contamination in a Canine Radius Fracture Gap Model
… stabilized with a silver-coated stainless steel bone plate and the other with an uncoated stainless steel bone plate. The ostectomy sites were inoculated with sterile PBS in 6 dogs and S. intermedius in the other 6 dogs. Each implant set was electrically stimulated with direct current for 20 …
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Auswirkung der Schwingstrecke und des Platten-Winkels einer Doppelplatten-Osteosynthese in einem ovinen Tibia-Defektmodell - eine Finite-Elemente-Analyse
Background Segmental defects of the bone occur mainly as a result of therapy for osteomyelitis, pseudarthrosis, resection of tumors and from complex fractures. The critical sized defect (CSD) is characterized by its inability to heal without treatment within the lifespan of an animal. Ovine tibial …
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Preclinical Evaluation of 3D Printed Biomaterials for Repairing Critical-Size Bone Defects
… Millions of patients each year suffer from non-healing bone defects secondary to trauma, cancer, osteomyelitis, or congenital anomalies. The standard of care for managing these cases necessitates bone reconstruction surgery. Although using autologous bone (autograft) or banked cadaveric bone …
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Development of Model Hydroxyapatite Bone Scaffolds With Multiscale Porosity for Potential Load Bearing Applications
… microporous topography alone did not influence bone healing in vivo, micropores were shown to provide tailorability of scaffold mechanical properties, provide a location for the storage and controlled release of a growth factor, and provide a location for bone integration inside the scaffold …
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Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins
Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems of limited availability and surgical morbidity. The use of allografts obtained …
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Bone Tissue Engineering: structures and strategies for functional scaffold design and evaluation
… after injury through the processes of bone healing. However, bone can suffer from a wide range of pathologies, cancers or congenital defects which lead to loss of bone mass and density. Current progresses in tissue engineering have shown great potential for creating biological …
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Osteogenese nach Laserosteotomie mit einem CO2-Laser im Vergleich zur Osteotomie mit konventioneller Sägetechnik - eine tierexperimentelle Studie
… potential advantages in comparison to classical bone incision by mechanical saws. In previous studies the bone healing was delayed due to the damage of the thermal effects compared to mechanical instruments like the bone saw. With 7 Beagles as an experimental model, a comparative study was done …
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Towards an autologous tissue engineering construct for craniofacial bone repair
Patients with critical-size bone defects, as a result of trauma, congenital malformations or tumor resections, generally have limited healing without clinical intervention. The autograft is the current standard of care for repair of these defects due to capacity for osteointegration and …
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Predictive modelling of the form and development of bone fracture healing
… of this study that the rate and formation of bone healing can be modelled mathematically and computationally, respectively, based on mechanical stimuli induced by the relative motion between bone fragments. To argue this case, the following hypotheses are tested; 1) the relationship between …
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INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION
… with biomaterials to accelerate wound healing in treating complicated wound with exposed bone (Wijewardena et al. 2011, DeFranzo et al. 2001). However, NPWT is not established as a treatment modality for orthopedic application and its mechanistic pathways of action on cellular …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
Bone has the innate ability to heal, but on occasion defects surpass a critical size capable of spontaneously healing. These critically-sized bone defects pose significant challenges for reforming bone continuity and often require surgical intervention to facilitate bone regeneration. Recently, …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
Autologous bone marrow grafting has been shown to aid in the healing of bone defects since the 1950s. Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative to harvest and transplantation of autologous bone for treatment of large …
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IMPLANT MATERIAL FUNCTIONALIZATION TO ENHANCE BIOACTIVITY IN ORTHOPAEDICS
… disability. One of the key challenges in bone healing and regeneration is the engineering of an implant that incorporates osseointegration to meet the metabolic demands of recovery. Although implants are typically expected to last ten years or more, longevity is still not assured and the …
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