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Showing 1 to 20 of 48 for “"Bone graft"”.
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Supercritical carbon dioxide-processed resorbable polymer nanocomposites for bone graft substitute applications
… clinical situations necessitate the use of bone graft materials to enhance bone formation. While autologous and allogenic materials are considered the gold standards in the setting of fracture healing and spine fusion, their disadvantages, which include donor site morbidity and finite supply …
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Flexible adaptation of iterative learning control with applications to synthetic bone graft manufacturing
… in fabricating advanced architecture synthetic bone grafts. These bone grafts, also known as synthetic bone scaffolds, are highly porous three-dimensional structures that provide a matrix to support the natural process of bone remodeling. Ideally, the synthetic scaffold will stimulate complete …
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The effect of Staphylococcus epidermidis on the pH and dissolution of substitute bone graft materials
… 11047 on the pH and dissolution of 5 different bone substitute materials. Part 1 – Measured the pH, calcium and phosphate of the culture medium in the presence and absence of the 5 bone substitute materials before and after autoclaving. Part 2 – Measured the pH of the culture medium in the …
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Densitometric Comparison of Autogenous Cancellous Bone Graft and Extracorporeal Shock Wave Therapy in the Tibial Tuberosity Advancement Procedure in Dogs
… (TTA) treated with autogenous cancellous bone graft (ACBG), extracorporeal shock wave therapy (ESWT), a combination of ACBG and ESWT, and absence of both ACBG and ESWT using densitometry. Methods: Dogs presenting for surgical repair of a cranial cruciate ligament rupture were randomly …
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Engineering Musculoskeletal Tissue: In vitro and in vivo evaluation of novel scaffolds and growth factors for bone regeneration
… The management of bony non-unions and large bone defects due to congenital deformities, trauma, degenerative disease, and oncological resection remains a complex challenge for orthopaedic surgeons. Currently, autologous bone grafting is the ‘gold standard’ treatment for non-unions and large …
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TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING
… trauma, but better options for treatment of bone injuries resulting in bony defects are still needed. Autologous bone grafts remain the standard treatment for segmental defects and non-unions. Engineered bone graft substitutes have failed to promote sufficient bone formation in large defects. …
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STUDIES IN THE DEVELOPMENT OF A XENOGRAFT-DERIVED BONE SCAFFOLD
Bone grafts are used in nearly one half of all musculoskeletal surgeries and represent an enormous health care expenditure. Tissue-engineered bone graft substitutes have garnered considerable attention to alleviate the risk of bone graft harvest and potential for disease transmission. Xenografts …
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Effectiveness of autogenous tooth bone used as a graft material for regeneration of bone in minipig
… was to evaluate the effect of autogenous tooth bone used as a graft material for regeneration of bone in artificial bony defect of the minipigs. MATERIAL AND METHODS: Five healthy minipigs, weighing about 35-40 ㎏, were used in this study. Four standardized artificial two-walled bony defect, 5㎜ …
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Preclinical Evaluation of 3D Printed Biomaterials for Repairing Critical-Size Bone Defects
… of patients each year suffer from non-healing bone defects secondary to trauma, cancer, osteomyelitis, or congenital anomalies. The standard of care for managing these cases necessitates bone reconstruction surgery. Although using autologous bone (autograft) or banked cadaveric bone (allograft) …
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The synergistic effect of pulsed electromagnetic fields and demineralized bone matrix on the osteogenic differentiation of mesenchymal stem cells
Orthopaedic bone grafting continues to be a mainstay in the treatment of non unions and other difficult to heal bone defects. Tissue engineering strategies have focused on providing bone graft materials that are osteoconductive, osteoinductive and osteogenic in order to achieve optimal bone …
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Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow
The current gold standard for bone graft material is autologous bone, which provides mechanical support, possesses factors that promote bone formation, and contains connective tissue progenitors (CTPs), a heterogeneous population of connective tissue stem and progenitor cells that contribute to …
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Histomorphometric Analysis of Maxillary Sinus Grafts: A Randomized Controlled Study
… was to evaluate and compare the degree of new bone formation through histomorphometric analysis following maxillary sinus grafts (MSG) using three different bone graft materials. Thirty-one MSG were performed using a lateral window approach for patients who required implant placement in …
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In vitro and in vivo assessments of PCL-TCP composites for bone tissue engineering
Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. Autologous bone graft poses no issues of rejection but will result in donor site morbidity and is limited by defect size. Allografts and xenografts are …
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THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL
It remains unknown whether bone grafting influences dural osteogenesis following cranial reconstruction. The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. …
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Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
… 2,300. During implant loosening, some of the bone in the femur is lost, which can make the revision more difficult. One way of handling bone loss has been the impaction technique. Allograft bone is morsellised and impacted into the defect before a prosthesis is inserted. Mechanically, the …
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Effect of Mechanical Environment on the Differentiation of Bone Marrow Stromal Cells for Functional Bone Tissue Engineering
Bone is the second most transplanted tissue after blood and the need for bone graft materials continues to rise at an average annual growth rate of over 18%. An engineered bone substitute consisting of a bone-like extracellular matrix deposited on the internal pores of a resorbable biomaterial …
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Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells
In the United States, nearly half a million bone graft operations are performed annually to repair defects arising from birth defects, trauma, and disease, making bone the second most transplanted tissue. Autogenous bone is the current gold standard for bone grafts; however it is in limited supply …
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Development and evaluation of the innovative 3D printed scaffolds for bone regeneration in vitro and in vivo /
Nowadays, the number of performed bone augmentation surgeries in various fields of medicine is growing. Bone augmentation is performed by restoring a bone defect with various bone substitutes. However, they fail to match all the ideal bone graft criteria. Therefore, the limitations of existing bone …
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Innovative Apatite/Bioactive Glass-based materials for biomedical applications
… in the past decades, to the development of bonegrafts materials as alternatives to allo- and autografts, due to the drawbacks associated with the employment of the latter ones (as for instance, transmission complications as well as immunological rejection and morbidity). Scientific research …
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Encapsulation of nanomagnetite within polycaprolactone microspheres for bone replacement
… need for the development of novel materials for bone regeneration. There is, however, with the exception of poly-(methyl methacrylate) a lack of mouldable polymeric fillers for irregular bone defects. In this thesis, we investigate the production of a new bone graft replacement combining …
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