Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 176 for “"Bone formation"”.
-
The Electrical Stimulation of Bone Formation.
In 1957 Fukada demonstrated that bone has piezoelectric properties, that is, bone produces electric current and potential in response to mechanical forces. The same phenomena were reported in 1962 by Bassett who found that the potentials developed in the area of compression were negative, and …
-
In Vitro and In Vivo Studies on Bone Formation
… to osteoporosis, the most common metabolic bone disease. These two aspects are: 1) mechanisms that are involved in the regulation of peak bone density, and 2) evaluation of the in vivo effects of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) as a potential means to treat …
-
Novel Molecules that Regulate Bone Formation and Bone Resorption
… is a disease characterized by decreased bone mass and microarchitectural deterioration of bone. Bone loss occurs when the increased bone resorption that occurs with age is not compensated by a corresponding increase in bone formation. Therefore, understanding the mechanisms which regulate …
-
Effects of Tricalcium Phosphate Coated Titanium on Adjacent Early Bone Formation
… have been used in order to promote more bone growth around these implants. Several different coating materials have been used to increase bone formation. Titanium (Ti) surfaces have been coated with hydroxyapatite (HA), plasma spray, and several blasting techniques have been implemented. …
-
Mesenchymal stem cell rescue for bone formation following stereotactic radiotherapy of osteosarcoma
… (OSA) is the most common form of primary bone cancer in dogs and humans. Curative-intent treatment options include amputation, radiation therapy or surgical limb salvage for local tumor control combined with adjuvant chemotherapy for prevention or delay of metastatic disease. Stereotactic …
-
The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… impairs the ossification of several bones. These bone defects correlate with an inability of Rb-deficient osteoblasts to properly exit the cell cycle. Similarly, we find that the mutation of E2f4 causes defects in embryonic ossification that are accompanied by a significantly greater …
-
Investigations into the Ulnar Response to Mechanical Stimuli Activating Lamellar and Woven Bone Formation
Woven and lamellar bone formation can be stimulated using mechanical loading. Woven bone forms rapidly in response to damaging loading in a disorganized manner with low mineral density. In contrast, lamellar bone formation can be induced in the absence of damage, and is characterized by its slow, …
-
The Effect of Lycii Radicis Cortex Extract on Bone Formation in vitro and in vivo
… skeletal disease. It is caused by decreased bone mass and enhances the risk of bone fracture. In this study, I aimed to discover novel herbal extract(s) for the treatment of osteoporosis. I screened 64 ethanol extracts of edible plants native to Korea for their ability to increase the …
-
Mechanisms for Osteoblast and Osteocyte Initiation and Sustainment of Bone Formation in Young-Adult and Aged Mice
<p>The cellular mechanisms for loading-induced bone formation, from osteocyte mechano-sensation to osteoblast-directed bone formation, are not well understood. Elucidating these mechanisms and identifying any processes that are disrupted in aged mice can aide in the development of new anabolic …
-
In vivo bone formation using Adipose Derived Stromal Stem Cells. The histomorphometry of the ovine defect model
The use of stem cells to augment the healing of bone defects represents an exciting new frontier in many surgical disciplines. This thesis verified the in vitro osteogenic capability of ovine Adipose Derived Stromal Stem Cells (ADSCs) and Bone Marrow Derived Stem Cells (BMSCs), examined the in vivo …
-
Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… gene. Additionally, these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The animals were not protected from bone loss following OVX, but retained the hypersensitivity seen in the intact mice. Mesenchymal stem/progenitor cells …
-
Expression and Function(s) of Parathyroid Hormone- Related Peptide in Intramembranous Bone Formation by Neonatal Rat Calvarial Cells In Vitro
… of the skeleton. The shortening of appendicular bones in knockout mice is explained by an effect of PTHrP on endochondral bone growth where it functions to inhibit the hypertrophy of chondrocytes in the epiphyseal growth plate. Whether or not PTHrP influences intramembranous ossification is less …
-
Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
… in the defect area and subsequently enhanced new bone formation. Although the rate and extent of bone formation was similar in bFGF group to those in empty defects for the period of the study, existence of woven bone in bFGF group suggests that bone formation is continuing while the lamellar …
-
The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… will heal through either intramembranous bone formation, involving the direct formation of bone callus, or endochondral bone formation, featuring a cartilage intermediary prior to bone callus formation. Both processes begin with inflammation, which sets the stage for a successful repair …
-
Hormones, Simulated Microgravity and Hypergravity affect Bone and other Physiological Systems in Zebrafish Larvae
… the consequences of altered gravity on bone development and on general physiology in an entire organism remains to date incomplete. We used altered drug treatment and gravity experiments to evaluate their effects specifically on bone formation and more generally on whole genome gene …
-
Mechanical Properties of Bone Due to SOST Expression: A 3-Point Bending Assessment of Murine Femurs
… is an osteocyte-expressed negative regulator of bone formation. The absence of SOST in the genome may have an effect on bone formation both during skeletal maturation and full maturity. This study attempts to determine significant differences in the mechanical properties of bone that expresses …
-
Microstructure-induced capillary force effects on penetration and release in hydroxyapatite bone scaffolds
Ceramic bone scaffolds with both microporosity (<50µm) and macroporosity (>100µm) are known to enhance bone formation. Including microporosity in a scaffold increases bone volume and distribution. The integration of the bone with the scaffold is also improved as both cells and mineralized bone have …
-
Bone growth following demineralized bone matrix implantation requires angiogenesis
… ossification in mice by implanting demineralized bone matrix (DBM) proximal to the femur to induce ectopic bone formation. TNP-470, a drug known to be anti-angiogenic, was used to inhibit vascularization during the time course of de novo bone formation in order to define the role of angiogenesis …
-
The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
<p>Bone is a dynamic organ that readily undergoes bone formation and remodeling in response to its mechanical environment. This response is accelerated during injury such as full fracture and or stress fracture, where woven bone must rapidly form for successful repair and restoration of mechanical …
Page 1 of 9