Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Bone disease"”.
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Acidosis and bone disease in chronic renal failure
… connection existed between acidosis and renal bone disease. We know that most creatures exposed to direct sunlight have evolved a metabolism that far from accumulating Vitamin D, tends rather to inactivate and excrete it, presumably to reduce the risk of toxic effects. Perhaps for similar …
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Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease
… plasma cells specifically migrate to the bone marrow, myeloma is often accompanied by osteodegenerative disease, which is characterized by an imbalance of bone resorption. Bone disease in multiple myeloma is driven by the dysregulated signaling of myeloma cells and the increased abundance …
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A Novel Approach for the Visualisation and Progression Tracking of Metastatic Bone Disease
Metastatic bone disease (MBD) is a common secondary feature of cancer that can cause significant complications, including severe pain and death. Current methods of diagnosis require a highly trained radiologist capable of interpreting medical images and recognising the sites of MBD. These medical …
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Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
… of osteopenia and avascular necrosis. Bone loss may be partially attributed to a steroid-induced decrease in the osteoblastic differentiation of multipotent progenitor cells found in the bone marrow. In order to determine if there is a change in the osteogenic potential of the bone …
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An Evaluation of the Limitations of the Technique of Dual Energy Absorptiometry in the Measurement of Bone Disease.
Many osteoporotic bone fractures would be largely preventable if a screening programme were successful in identifying those most at risk or in the early stage of the disease. Assessment of bone mass by bone mineral density measurement has developed rapidly in the last 15 years from Single Photon …
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The Role of Maternal High Fat Diet in the Pathogenesis of Metabolic and Bone Disease in the Adult Offspring
Chronic diseases such as osteoporosis, type 2 diabetes, and cardiovascular disease are diseases of long duration, slow progression, and are by far the leading cause of death worldwide. A growing body of evidence links adverse exposures in early development with an increased risk of chronic diseases …
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MRI Quantification of Cortical Bone Microstructure and Material Composition with Ultrashort Echo Time Sequences
Quantitative imaging assessment of cortical bone structure and material composition provides additional information about bone health beyond conventional radiographic assessment of bone mineral density (BMD). Large prospective studies have found that cortical bone imaging biomarkers are associated …
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ΜΕΤΑΒΟΛΙΣΜΟΣ ΤΟΥ ΑΣΒΕΣΤΙΟΥ ΚΑΙ ΟΣΤΕΟΠΑΘΕΙΑ ΣΕ ΧΡΟΝΙΟΥΣ ΑΛΚΟΟΛΙΚΟΥΣ
… TO DELINEATE THE PATHOGENESIS OF THE ALCOHOLIC BONE 15 CHRONIC ALCOHOLIC MEN, AGED 29-55 YEARS WERE STUDIED. VARIOUS BIOCHEMICAL, RADIOLOGICAL, HISTOLOGICAL AND RADIO-IMMUNOLOGIC PARAMETERS WERE USED. THE PATIENTS WERE FOUND TO HAVE A HIGH (66,6%) PREVALENCE OF OSTEOPENIA AND BONE …
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Osteoporosis education in college-age women
<p>Osteoporosis, a degenerative bone disease, is a preventable disease. The purpose of this study was to determine if an educational intervention would increase knowledge and influence women to change their behaviors (i.e., exercise and dietary calcium intake) related to osteoporosis.</p> <p>A …
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Studying Collagen with PyrATS: Pyrene-Appended Trimeric Systems
… such as osteogenesis imperfecta, or "brittle bone disease." There is significant interest in understanding the factors that drive collagen folding and stability, but studying native collagens is difficult because they are hundreds of amino acids in length. This thesis describes a series of …
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Acetabular reconstruction using a ?Cone Cup? prosthesis in a series of 13 patients
… Endoprosthetic reconstruction of major pelvic bone loss in oncology and revision arthroplasty surgery is associated with high complication rates. However, comparative data for reconstructive methods are limited. We present short-term clinical, radiological, and functional outcomes of the …
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A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones
<p>The importance of vitamin D to bone health is well known, yet new research has linked vitamin D to numerous chronic diseases severely affecting our society. Recent studies have suggested vitamin D plays a critical role in conditions such as diabetes, cancers, and cardiovascular diseases. These …
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Studies on the Role of Vitamin D in the Mineralization of Bone: A Vitamin D-dependent Serum Protein That Stimulates the Incorporation of 45 Calcium by Bone Cells in Vitro
… in the 1920's established that rickets, a bone disease in which newly synthesized osteoid matrix does not calcify, was caused by a dietary deficiency in the fat-soluble vitamin D. These investigators concluded that vitamin D was necessary for the normal mineralization of bone. After 50 …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
Bone metastases are a frequent clinical complication associated with cancer. The aim of this PhD thesis was to set up a model system for the study of tumour cell – bone cell interactions in vitro, ex vivo and in vivo and to use this system to test the efficacy of a novel therapeutic agent for the …
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Outcomes after percutaneous leverage reduction and pinning for irreducible metaphyseal fractures of distal radius in children
… presence of another skeletal injury, metabolic bone disease and congenital deformity. At the last follow up, fracture site direct tenderness, range motion of wrist joint, grasp power, duration of bone union, and complications were recorded for the clinical outcome evaluation. RESULTS: All …
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Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling
Skeletal fractures due to bone disease impact an estimated 1.5 million Americans per year, creating a large economic burden on our society. Treatment of bone diseases prior to fracture often involves bisphosphonates (current gold-standard in osteoporosis care and prevention). Although …
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Tissue Sodium in CKD Patients
… is altered in patients with chronic kidney disease (CKD) due to long term loading, and sodium (23Na) can be deposited in the skin, muscle and skeleton. We measured 23Na content in these tissues of CKD patients, using 23Na magnetic resonance (MR) imaging. Methods: This is a pilot …
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Evaluation of Current Decision Rules and Healthcare Professional Practices for Detecting Osteoporosis Risk in the Young Adult Population
… factors. An individual’s risk for experiencing a bone fracture as a senior citizen increases without early intervention. Healthcare professionals do not have access to validated survey tools to identify young adults in need of osteoporosis prevention education, although survey tools to identify …
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The Effects Of Carbonated Soft Drinks On Bone Mineral Density In College Age Women
… public health problem. Also called, 'the silent disease' or 'fragile bone disease', osteoporosis results from low bone mass (Gammage & Klentrou, 2011; NOF, 2013; Swann, 2012). Currently, 44 million Americans have osteoporosis; 80% of which are women (NOF, 2011). Few studies, most implemented in …
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Morphological and mechanical analysis of the porous structure of cortical bone
Introduction: Bone is a complex hierarchical material that can be studied at many levels. For diseases like osteoporosis, characterized by bone loss, macro-level tests like DEXA scanning can predict an increased fracture risk, but cannot detect the driving mechanism.As a porous, anisotropic …
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