Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Bone cancer"”.
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Bone Cancer Incidence in Texas Counties With Elevated Radium Content in Drinking Water
… the incidence rate of a site-specific cancer in counties with elevated levels of a naturally occurring radionuclide present in drinking water. The radionuclide present is radium which deposits in bone tissue and emits alpha particle radiation when it decays. Radium dose and …
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Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
… synthase (FPPS) and are clinically used to treat bone related disorders such as osteoporosis and bone cancer. Here we describe the development, testing and study of the mechanism of action of novel bisphosphonates as anti-bacterial and anti-cancer agents. We identified a FPPS bisphosphonate …
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Complexation of trivalent lanthanides by three diphosphonate ligands in the blood plasma
It has been shown that ¹⁵³Sm complexed with the bone seeking ligand ethylene-diaminetetramethylene phosphonate (EDTMP) is effective in pain palliation therapy of bone cancer. Blood plasma models for this ligand with Sm(III) and Ho(III) have been successfully constructed explaining the differences …
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Directed biogenic fabrication : programming cells and their ecosystems to grow civil infrastructure
… materials synthesized by two types of bone cancer cells. This thesis makes contributions to the fields of materials science, biological engineering, civil engineering, digital fabrication, and computational design..
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Omics approach towards understanding the function of bioactive lipids in osteosarcoma
Osteosarcoma is the most common form of primary bone cancer in humans and well as dogs. The treatment options for OS include a multi-agent induction chemotherapy and radical excision of the tumor followed by adjuvant chemotherapy. Despite the aggressive treatment course, the survival rates are …
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A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… to small molecules that inhibit the growth of cancer cells through the Hippo signaling pathway. Ewing’s sarcoma is the second most commonly diagnosed pediatric bone cancer. While there are common forms of general treatment available, there are little to no treatments for recurrent cases, as …
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Improving cancer therapy strategies via cellular stress and immune modulation
… therapies, metastatic and chemoresistant cancers continue to exhibit poor clinical outcomes. This dissertation investigates two distinct therapeutic strategies designed to overcome tumor resistance and improve therapeutic efficacy. The first component of this work focuses on the small …
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Inhibiting metastatic potential: an analysis of migratory body formation in chondrosarcoma
Chondrosarcoma (CHS) is the 2nd most prevalent bone sarcoma. Approximately 27% of all bone cancer cases reported to the International Agency for Research on Cancer (IARC) database are CHS. CHS tends to primarily affect adults above the age of 30 with 70% of cases reported affecting patients of 40 …
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Studies in GPCR and Chromosomal Control
… Ewing’s Sarcoma is a malignant pediatric cancer found in bones and soft tissues. It is the second most diagnosed bone cancer found in children. Current treatment for this disease is limited as the origin and mechanisms of metastasis are poorly understood. Our collaborators at the Baylor …
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Identifying CDK8/19 as a Novel Regulator of EWS-FLI1 Function in Ewing Sarcoma
Ewing sarcoma, a pediatric bone cancer, is characterized by the translocation of the Low Complexity (LC) domain from an RNA binding protein (EWSR1, FUS, or TAF15) with the DNA binding domain of an ETS transcription factor. The translocation EWS-FLI1 accounts for 90% of Ewing sarcoma tumors and a …
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Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non-Invasive Mechanical Loading
… develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the …
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Analysis of DNA methylation in canine osteosarcoma using next generation sequencing technology
Osteosarcoma is the most common type of malignant bone cancer found in dogs (Canis familiaris), with in excess of 25,000 cases diagnosed annually. DNA methylation is a form of epigenetic modification that is essential for normal development and gene transcription regulation; however, aberrant DNA …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
Osteosarcoma (OS) is the most common bone cancer in dogs. It is biologically aggressive and <20% survive >2 years with standard therapy. Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene …
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Investigating Human Cell Influence on the Micromechanical Environment of a 3D-Printed Bone Tissue Model
Advanced stages of breast cancer (BC) are associated with the spread of tumors to distant sites, or metastasis, with the skeletal system being one of the most common locations for metastasis, with rates as high as 70%. Despite this, the mechanistic factors behind BC cell recruitment, infiltration, …
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Incidence of cancer among residents of high temperature geothermal areas in Iceland: A census based study 1981 to 2010
… and radon, is associated with the risk of cancer. Design: Observational cohort study where the population of a high temperature geothermal area (35 707 person years) was compared with the population of a cold, non-geothermal area (571 509 person years). The follow up from 1981 to 2010 was …
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Mesenchymal stem cell rescue for bone formation following stereotactic radiotherapy of osteosarcoma
… (OSA) is the most common form of primary bone cancer in dogs and humans. Curative-intent treatment options include amputation, radiation therapy or surgical limb salvage for local tumor control combined with adjuvant chemotherapy for prevention or delay of metastatic disease. Stereotactic …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… (OS) is the most common primary malignant bone cancer in children. Despite the improvement in multiagent chemotherapy, 5-year survival rate for metastatic OS is only 20% to 30%. One of the main reasons for failure in therapy is due to the activation of autophagy in metastasis and …
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Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
Osteosarcoma (OS) is the most common primary bone cancer in dogs, yet therapies for pets with metastatic OS remain clinically ineffective. With the advent of precision medicine, strong scientific and clinical impetus exists to further investigate druggable molecular perturbations that might …
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Isolation and characterisation of canine osteosarcoma cells to investigate mechanisms of chemoresistance
… Osteosarcoma (OSA) is the most prevalent primary bone cancer in humans and is 27 times more prevalent in dogs. Unfortunately, over the past 2 decades, the rate of 5-year survival for metastatic OSA has not improved in humans or dogs. It is thought that this is mainly due to chemoresistance and …
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Computer Aided Diagnosis Systems for Digital Analysis of Osteosarcoma and Skin Cancer
… Analysis and Tracking. Osteosarcoma is a type of bone cancer in children with an estimated 400-900 new cases each year in the United States. The current treatment plan for osteosarcoma involves a histopathology analysis after ten weeks of chemotherapy. Pathologists manually evaluate Haemotoxylin …
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