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Showing 1 to 19 of 19 for “"Bone Scaffold"”.
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STUDIES IN THE DEVELOPMENT OF A XENOGRAFT-DERIVED BONE SCAFFOLD
Bone grafts are used in nearly one half of all musculoskeletal surgeries and represent an enormous health care expenditure. Tissue-engineered bone graft substitutes have garnered considerable attention to alleviate the risk of bone graft harvest and potential for disease transmission. Xenografts …
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Additive manufacturing of stiffness optimised auxetic bone scaffold using cobalt-chromium-molybdenum superalloy
… tissue engineering constructs, such as bone scaffolds for critical-size defects. Emerging early-stage studies have shown the potential of auxetic architecture in increasing cell proliferation and tissue reintegration due to their −𝜐. However, research on the development of stiffness …
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Additive manufacturing of triply periodic minimal surface informed load bearing stiffness matched tibial bone scaffold
… thesis investigates the development of titanium scaffolds based on Triply Periodic Minimal Surface (TPMS) structures to create bone implants that effectively match the mechanical properties of the tibia. The primary goal is to design and fabricate titanium (Ti6Al4V) scaffolds that provide optimal …
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Production of temporary bone scaffold reinforced with OPEFB-CMC from oil palm empty fruit bunch
Bone fracture is a common injury because of its nature position that is mostly closest to skin and exposed to excessive compression and depression. Current treatment for bone fracture employs the scaffolding approaches which are specifically positioned for a certain period of time. These allow the …
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Mechanical and Cellular Response to Biomineralization of Ovalbumin Scaffolds for Bone Tissue Engineering
… the feasibility of ovalbumin (OVA) as a bone scaffold material have found its cost, availability, interaction with cells, and ability to degrade in the body into safe byproducts to be ideal for such an application. However, weak mechanical properties cause hesitation in the use of OVA as …
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Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement
… explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing the bone scaffold are triple co-precipitation of type-I collagen, chodroitin-6-sulphate, and calcium phosphate …
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FABRICATION AND CHARACTERIZATION OF PHOTO-CROSS-LINKABLE NANOCOMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING
The large-scale bone defect is one of the biggest challenges in orthopedic surgery. Here, we proposed to use the photocrosslinkable nanocomposites for the fabrication of the bone scaffold and artificial periosteum. Firstly, we prepared nanocomposite ink composed of tri-block polymer and …
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Costruzione di uno scaffold vascolarizzato per la chirurgia ortopedica
… aims The aim is to improve the treatment of the bone losses at the metacarpal bones level (both diaphysis and epiphysis) combining microsurgery, tissue engineering and biomaterials, so to minimize the donor side morbidity and optimize healing and outcomes. Methods Pre-operative controlateral …
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Microstructure-induced capillary force effects on penetration and release in hydroxyapatite bone scaffolds
Ceramic bone scaffolds with both microporosity (<50µm) and macroporosity (>100µm) are known to enhance bone formation. Including microporosity in a scaffold increases bone volume and distribution. The integration of the bone with the scaffold is also improved as both cells and mineralized bone have …
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Selective laser sintering of bioactive glass scaffolds and their biological assessment for bone repair
<p>"Bone scaffold fabrication using powder-bed based additive manufacturing techniques, like the selective laser sintering (SLS) process, provides control over pore interconnectivity, pore geometry, and the overall shape of the scaffold, which aids in repairing different regions of the bone. The …
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Synthesis and characterization of implants for bone substitutions made of biomedical apatites containing silicon
In the last decades the development of bone substitutes characterized by a superior biomimetism has become of particular interest, owing to the increasing economic and societal impact of the bone diseases. In the present work of research the development of bone substitutes characterized by improved …
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Production of hard tissue scaffolds using three-dimensional printing method
Synthesised bone replacement scaffolds provide the possibility to individually tailor properties, overcome limited donor availability and improve osteointegration. The aim of bone tissue engineering is to provide solutions to these problems by making available high quality transplants that can be …
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Development of the chick chorioallantoic membrane (CAM) model to assess tumour growth and drug response in osteosarcoma and bladder cancer
… BC cell behaviour was assessed in a bone-like environment, simulated using a NuOSS scaffold, and compared to a non-bone-like extracellular matrix. Furthermore, a STAT3 inhibitor (STAT3-IN-1) will be applied to HOS-143B cells to evaluate its effects on tumour growth and behaviour in an …
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The effect of pore size and porosity on capillary pressure in microporous hydroxyapatite samples
Microporosity (<50μm) in hydroxyapatite (HA) scaffolds is known to improve bone ingrowth. The mechanism for the improvement is thought to be in part due to capillary forces induced by the micropores. The micropore-induced capillary forces can self load cells into the scaffolds. In this study, the …
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Reduced order modelling of bone resorption and formation.
The bone remodelling process, performed by the Bone Multicellular Unit (BMU) is a key multi-hierarchically regulated process, which provides and supports various functionality of bone tissue. It is also plays a critical role in bone disorders, as well as bone tissue healing following damage. …
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Macro- and micro-structural features direct bone regeneration in patterned biphasic calcium phosphate scaffolds
The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate …
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Synthesis and Structural Studies of Calcium and Magnesium Phosphinate and Phosphonate Compounds
… and phosphonates with possible applications as bone scaffolding materials or additives to bone cements. The challenge to the chemistry of the alkaline earth phosphonate target compounds includes poor solubility of compounds, and poorly understood details on the control of the metal's …
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Quantitative image analysis of in vivo microstructure and growth factor effects in hydroxyapatite bone scaffolds
… agents, such as BMP-2, are known to improve bone formation when combined with scaffolds. Microporosity (<20µm) has also been shown to influence bone regeneration in calcium phosphate (CaP) scaffolds. However, many studies use only the term “osteoconductive” to describe the effects of BMP-2 …
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Bioactive Cellulose Nanocrystal Reinforced 3D Printable Poly(epsilon-caprolactone) Nanocomposite for Bone Tissue Engineering
Polymeric bone scaffolds are a promising tissue engineering approach for the repair of critical-size bone defects. Porous three-dimensional (3D) scaffolds play an essential role as templates to guide new tissue formation. However, there are critical challenges arising from the poor mechanical …