Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 97 for “"Bone Regeneration"”.
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Biomaterials for bone regeneration
… of hydroxyapatite (HA)-based biomaterials for bone repair: calcium phosphate microspheres and bioactive silicate glass scaffolds. These biomaterials were prepared with modified compositions and microstructures and then were evaluated for bone regeneration.</p> <p>The open HA microspheres with …
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
<p>Bone tissue engineering represents a strategy for the repair or regeneration of damaged bone in the body. The science underlying this clinical therapy bridges the traditional fields of cell biology, materials science and mechanical engineering with the aim to identify how cells behave on …
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Polypyrrole : an interactive substrate for bone regeneration
Current methods of bone repair rely on autografts (bone from a donor site) and allografts (bone from human cadaver). However, these methods are plagued with disadvantages. There is a clear and urgent need to provide alternatives for regenerating and repairing bone. Bone is known to be one of the …
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Composite gelatin delivery system for bone regeneration
… to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery system, designed to regenerate bone, holds much promise as an alternative to bone grafts. The chemical properties of gelatin were examined through zeta potential …
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Development of polyHIPE scaffolds for improved bone regeneration
Critical size bone defects resulting from trauma or disease are challenging to treat due to the size and shape of the defect. Autologous tissue remains the gold standard due to the superior healing potential but harvesting material is challenging due to donor site complications. We have designed a …
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Antibiotic-free PHA-based antibacterial materials for bone regeneration
… and fight infections. In the biomedical field, bone regeneration is one of the applications with the highest risk of infection. Therefore, alongside biological and functional properties, materials used for this application should be able to provide antibacterial features able to inhibit …
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Bi-functional scaffold for bone regeneration after osteosarcoma resection
L'abstract è presente nell'allegato / the abstract is in the attachment
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Influence of Biomaterials in Alveolar Bone Regeneration and Preservation
… documented. However, they require a minimal bone quantity (in height and thickness). But alveolar bone defects are very frequent, for instance due to periodontitis, traumatism or acute dental infection. Moreover, a simple tooth extraction leads to significant bone resorption. Therefore, …
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Metal-doped silicate microparticles for collagen scaffold-guided endochondral bone regeneration
… ossification (EO) describes a process in which bone tissue builds up via a cartilaginous phase. In contrast to classical biomaterial approaches, which address bone regeneration via direct, intramembranous ossification (IO), a collagen scaffold was shown to stimulate endochondral healing of large …
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Development of biodegradable, biomimetic hydrogels modulating cellular function for guided bone regeneration
… modified with bioactive peptides for guided bone regeneration. First, we examined the cytotoxicity of each component of the OPF hydrogel formulation and the resulting crosslinked network. Marrow stromal cells (MSCs) exhibited different viability with respect to OPF synthesized with …
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
<p> Over the years, the repair of bone defect is an increasing challenge for reconstructive surgery. Due to disadvantage of autograft and allograft, including limit of bone supply, high morbidity and potential immune response, synthetic scaffold have been studied as a promising strategy for tissue …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
Bone has the innate ability to heal, but on occasion defects surpass a critical size capable of spontaneously healing. These critically-sized bone defects pose significant challenges for reforming bone continuity and often require surgical intervention to facilitate bone regeneration. Recently, …
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Macro- and micro-structural features direct bone regeneration in patterned biphasic calcium phosphate scaffolds
The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate …
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Differential human mesenchymal stem cell responses across multi-compartment scaffolds for tendon-bone regeneration
… loads from aligned, fibrous tendon to stiff bone. Injuries to the rotator cuff account for 4.5 million physician visits per year and an annual 250,000 surgeries in the United States alone. However, current surgical techniques do not provide regeneration at the tendon bone junction (TBJ) and …
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Supporting bone regeneration: Evaluation of endocrine peptides and delivery systems for local application of lactoferrin
… outcomes. Delivery systems that can enhance bone formation, accelerate regeneration and healing, and ultimately restore bone integrity and strength, are still largely missing. Aim We aimed to evaluate the myokine irisin and the neuropeptide orexin as potential bone anabolic factors and to …
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Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
… of osteopenia and avascular necrosis. Bone loss may be partially attributed to a steroid-induced decrease in the osteoblastic differentiation of multipotent progenitor cells found in the bone marrow. In order to determine if there is a change in the osteogenic potential of the bone …
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Bone Regeneration Potential of Mesenchymal Stromal Cells derived from a Clinically Relevant Rat Model of Osteoporosis
… with these fractures, characterized by reduced bone mass, increased bone fragility. There exists a high failure rate in the translation of treatments to osteoporotic populations. Mesenchymal stromal cell (MSC) transplantation as a therapeutic strategy for OP has not yet been examined in clinical …
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