Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Bone Growth"”.
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Calcium Requirement Distribution Via Bone Growth Modeling
… focuses on estimating calcium requirements using bone growth data in adolescents. We estimate the peak rate of growth of bone and the variability of this peak growth rate to provide Dietary Reference Intakes (DRIs) for calcium. The specific DRIs of interest are Estimated Average Requirement (EAR) …
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Bone growth following demineralized bone matrix implantation requires angiogenesis
… ossification in mice by implanting demineralized bone matrix (DBM) proximal to the femur to induce ectopic bone formation. TNP-470, a drug known to be anti-angiogenic, was used to inhibit vascularization during the time course of de novo bone formation in order to define the role of angiogenesis …
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Cortical bone growth in response to local strain environment
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms
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Hereditary multiple exostosis : a study in abnormal bone growth
… is a generalised, heritable disorder of bone, characterised by the appearance of numerous cartilagecappecl exostoses at the juxta-epiphysial regions of the endochondral skeleton. The condition was apparently known even in Hunter's day and most of its characteristic features were described …
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Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extracts
… marine-organism derived osteogenic (promoting bone formation) activity, using extracts produced from a wide range of taxonomic groups sourced from the west coast of Ireland. In total, 100+ extracts were screened <i>in vitro</i> for their osteogenic potential, using both a human foetal …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
During bone growth, remodeling, and fracture repair, skeletal lineage cell responses require the coordinated activation of multiple transcriptional programs. As defective genetic regulation of bone formation leads to both developmental and metabolic skeletal diseases, identifying and characterizing …
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Bone growth during puberty and the effects of exercise and calcium on bone mass accrual
… are time periods characterised by the rapid growth and development of the skeletal system. The timing and magnitude of skeletal development varies considerably between individuals however, environmental factors may make significant contributions to the variance in bone mass. To optimise the …
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Dietary calcium: Effect of bioavailability and level of intake on bone growth, development and maintenance in the rat
… to determine the effect of calcium intake on bone growth, development and maintenance using the rat as a model. The central hypotheses that were tested were: (I) dietary calcium provided from a low bioavailable source will compromise both bone quality and bone quantity in the young and old …
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Childhood Growth In An Oneota Community: Examining Long Bone Growth Differences In The The Juveniles At Norris Farms 36
… This thesis identified differences in long bone length among juveniles interred with Oneonta and Mississippian grave goods in the Norris farms 36 cemetery. Correlation, linear regression analysis, and a statistical t-test of measurements from the left femora and humeri of 135 of the 137 …
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Effects of restricted growth rate, elevated vitamin and mineral levels and aging on bone growth, histological integrity and biochemical composition of articular cartilage in boars
… NRC vs 100% NRC) and the effects of aging on bone growth, histological lesioning and biochemical composition of articular cartilage from growing boars was examined. Growth of the radius and tibia was characterized by radiography at eight equal time points from 110 to 330 d of age. Although ad …
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Wnt signaling in zebrafish fin regeneration : chemical biology using a GSK3β inhibitor
Bone growth can be impaired due to disease, such as osteoporosis. Currently, intermittent parathyroid hormone (PTH) treatment is the only approved therapy in the United States for anabolic bone growth in osteoporosis patients. The anabolic effects of PTH treatment are due, at least in part, to …
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Identification of Molecular Targets for the Treatment of the Skeletal Phenotype in Lysosomal Storage Disorders
… secretion in chondrocytes, is necessary during bone growth. However, whether mTORC1 and autophagy play any role in the pathogenesis of skeletal disorders is still unknown. In this thesis work I show that an altered mTORC1 signaling impairs autophagy and consequently bone growth in lysosomal …
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Macro- and micro-structural features direct bone regeneration in patterned biphasic calcium phosphate scaffolds
The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… of this project is to develop a synthetic bone graft for the spinal fusion, combined with bone growth enhancing factors named bone and cartilage stimulating peptides (BCSP®). The focus of this present study is to assess BCSPs’ performance in various concentrations with respect to their …
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Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]
… is one of the most influential hormones on bone growth and maintenance throughout the life cycle in both men and women, but there are still unknown roles of estrogen and the estrogen receptors in males. In addition, exposure to xenoestrogens, or environmental compounds that have …
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Computer modelling of the development of the trabecular architecture in the human pelvis
The influence of mechanical loading upon bone growth and remodelling has been widely studied. It has been suggested that functional bone growth is evident within the human adult pelvis, where the internal trabecular structure is purported to align to the principal strain trajectories induced during …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
Bone has the innate ability to heal, but on occasion defects surpass a critical size capable of spontaneously healing. These critically-sized bone defects pose significant challenges for reforming bone continuity and often require surgical intervention to facilitate bone regeneration. Recently, …
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The mechanical and magnetic behaviour of sintered fibre networks and their suitability for a therapeutic, biomedical application
… is the magnetic-mechanical stimulation of bone growth around prosthetic implants after joint replacement surgery. The loosening of prosthetic implants in the human bone is one of the current research topics of prosthesis design. **Objectives and motivation:** The present study aims at …
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Non-invasive characterization of bone tissue and modeling of bone at micron and sub-micron levels
Bone is a composite material with a hierarchical structure, spanning from a nanoscale to a whole bone level. We focus on modeling bone at two structural length scales, namely a micron level and a sub-micron level, and perform a feasibility study of using ultrasound to detect bone growth in a limb …
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Multi-scale structural design of titanium implants for improved osseointegration
Osseointegration success of bone-interfacing implants is reduced for many compromised patients, necessitating improved implant design. Though material and mechanical properties of titanium make it attractive for load-bearing dental and orthopaedic implants, limited advancements have been made to …
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