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Showing 1 to 20 of 29 for “"Bone Grafts"”.
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Nanomaterials in synthetic bone grafts. Growth factor release, MR imaging and toxicity aspectspromotor
Contains fulltext : 85860.pdf (Publisher’s version ) (Open Access)
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THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL
It remains unknown whether bone grafting influences dural osteogenesis following cranial reconstruction. The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. …
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In vitro and in vivo assessments of PCL-TCP composites for bone tissue engineering
Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. Autologous bone graft poses no issues of rejection but will result in donor site morbidity and is limited by defect size. Allografts and xenografts are …
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Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells
In the United States, nearly half a million bone graft operations are performed annually to repair defects arising from birth defects, trauma, and disease, making bone the second most transplanted tissue. Autogenous bone is the current gold standard for bone grafts; however it is in limited supply …
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Advances in Bone Tissue Engineering
Bone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of …
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Flexible adaptation of iterative learning control with applications to synthetic bone graft manufacturing
… in fabricating advanced architecture synthetic bone grafts. These bone grafts, also known as synthetic bone scaffolds, are highly porous three-dimensional structures that provide a matrix to support the natural process of bone remodeling. Ideally, the synthetic scaffold will stimulate complete …
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Preosteoblast Behavior on a Synthetic Calcium Phosphate Scaffold Coated with Cell Derived Matrix
<p>Bone grafts are commonly used for the treatment of large bone defects. Biodegradable, synthetic bone grafts combined with cells and growth factors as a tissue engineered construct can provide benefits over the common autografts and allografts currently used. Calcium phosphate (CaP) materials …
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TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING
… trauma, but better options for treatment of bone injuries resulting in bony defects are still needed. Autologous bone grafts remain the standard treatment for segmental defects and non-unions. Engineered bone graft substitutes have failed to promote sufficient bone formation in large defects. …
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Osteonecrosis. Prognosis and Prevention of the Consequences of Osteonecrosis
… (ON) is defined by the in situ death of bone cells, osteocytes, hematopoietic and fatty marrow precursor cells. Events and risk factors known to be associated with ON are femoral neck fracture, hip dislocation, slipped capital femoral epiphysis in children, humeral head fracture and …
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Evaluation of Two Techniques of Cancellous Bone Grafting of Experimental Subchondral Bone Cysts in the Medial Femoral Condyles of Horses
… 5 horses to mimic clinical cases of subchondral bone cysts after debridement. The defects were created with either a standard square ended drill bit or a compaction drill bit. The compaction drill bit compresses bone laterally and distally creating a dense wall and floor. Twelve-mm sternal …
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Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins
Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems of limited availability and surgical morbidity. The use of allografts obtained …
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STUDIES IN THE DEVELOPMENT OF A XENOGRAFT-DERIVED BONE SCAFFOLD
Bone grafts are used in nearly one half of all musculoskeletal surgeries and represent an enormous health care expenditure. Tissue-engineered bone graft substitutes have garnered considerable attention to alleviate the risk of bone graft harvest and potential for disease transmission. Xenografts …
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Synthesis And Characterization Of Nanocrystalline Hydroxyapatite Powder; And The Effects Of Oxide-based Sintering Additives On Tricalcium Phosphate
… (CP) materials have been used extensively for bone replacement and augmentation due to their similarity to the mineral component of bone. In addition to being non-toxic, they are biocompatible, not recognized as foreign materials in vivo, and most importantly, exhibit osteoconductive behavior, …
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Factors affecting bone cell growth and differentiation under differing culture conditions
… into osteoblasts is an important part of the bone growth and remodeling process. This process can be exploited to help solve the problem of bone wound healing. Because of problems with bone grafts, implantation of biodegradable 3D scaffolds seeded with MSCs has been suggested. However, …
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Fabrication and Characterization of Titanium-doped Hydroxyapatite Thin Films
… used in many biomedical applications including bone grafts and joint replacements. Due to its structural and chemical similarities to human bone mineral, HA promotes growth of bone tissue directly on its surface. Substitution of other elements has shown the potential to improve the bioactivity …
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Composite gelatin delivery system for bone regeneration
… to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery system, designed to regenerate bone, holds much promise as an alternative to bone grafts. The chemical properties of gelatin were examined through zeta potential …
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Isolation of Mesenchymal Stem Cells Derived from Adult Bone Marrow and Umbilical Cord Blood and Their Potential to Differentiate into Osteoblasts
… system. Despite major strides in the field of bone regenerative medicine during the years, current therapies, such as bone grafts, still have several limitations. Multipotent stem cells, such as mesenchymal stem cells (MSCs) are promising candidates for tissue repair because of their …
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Application of Calcium Phosphate based gels for encapsulation of therapeutic molecules
There is increasing clinical need for bone substitutes because of the limited supply of autogenous tissue, and the significance of inherited or other bone diseases. The ultimate aim of this study was to form calcium phosphate (CaP) based matrices as bone grafts for medical applications. Amongst CaP …
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Design, characterization, and reinforcement of mineralized collagen-glycosaminoglycan scaffolds for orthopedic wound repair
… the use of either autologous or allogenic bone grafts for orthopedic implants as the gold standard. However, this standard of treatment has been plagued with concerns over the size, geometry, donor site morbidity, disease transmission, and availability. To address these concerns, the …
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Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow
The current gold standard for bone graft material is autologous bone, which provides mechanical support, possesses factors that promote bone formation, and contains connective tissue progenitors (CTPs), a heterogeneous population of connective tissue stem and progenitor cells that contribute to …
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