Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Bone Fragility"”.
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Risk factors for bone fragility and fracture in postmenopausal women
… of this thesis was to evaluate risk factors for bone fragility and fractures in postmenopausal women in a long-term perspective. The study period spanned from the age of 48 to age 82 and is thus unique in its length. The studied sample was homogeneous and consisted of 390 north European women …
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NEAR INFRARED SPECTROSCOPIC ASSESSMENT OF BONE WATER BINDING TO COLLAGEN AND MINERAL
Cortical bone fragility increases with age, therapeutic drug use and disease states. Clinically, bone fragility is evaluated by assessment of bone mineral density (BMD); however, studies have shown that other factors such as bone architecture, cell turnover and tissue composition influence bone …
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The Interplay Between Bone Homeostasis, Permeability, and Fracture Toughness
<p>Healthy bones are strong and tough, able to resist plastic deformations and withstand crack propagation. These essential mechanical properties emerge from a complex hierarchical structure and the activity of osteocytes, bone cells residing in tiny cavities within the matrix. The lacunar …
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Understanding Hearing Loss in Osteogenesis Imperfecta
… in collagen type I. The hallmark of OI is bone fragility, leading to frequent fractures in childhood that tend to decrease after puberty. Hearing loss in OI often begins in childhood and typically progresses with age. Affecting up to 94% of people with OI, hearing loss often presents …
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Bone fracture toughness of estrogen deficient rabbits
Bone mass is commonly used as an indicator of fracture risk. It has been shown in numerous studies that bone loss causes increased bone fragility and risk of fracture. It has also been shown that 50% of patients with osteoporotic vertebral compression fractures have the same bone mass as normal age …
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Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
… (OI), also commonly referred to as brittle bone disease, is a heritable connective tissue disorder occurring in roughly 1:15,000 births. OI arises as a result of mutations in the type I collagen genes, COL1A1 and COL1A2, approximately 85 % of the time with the remaining 15 % of cases arising …
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
<p>Osteoporosis is the most common bone metabolic disorder, affecting over 200 million people globally. It is characterized by bone mass depletion and microarchitectural deterioration, leading to bone fragility and susceptibility to bone fracture. Genetic factors, estrogen deficiency, and …
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Diffuse Damage Repair Mechanism in Bone
<p>Bone microdamage is a result of fatigue, creep or ‘wear and tear’ caused by physiological activities and largely contributes to bone fragility. Bone, unlike engineered materials, has the ability to repair the microscopic cracking or microdamage through targeted, osteoclast-mediated bone …
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Association Analyses of Estrogen Receptor a Gene Polymorphisms with Bone Geometric Property at The Femoral Neck in Caucasian Nuclear Families
… of osteoporosis is its association with bone fragility. Bone geometry is an important risk factor for fracture, independent to BMD, and is genetically determined. However, genetic studies on bone geometry compared with BMD are scarce. Estrogen receptor a (ER-a) gene and its products have …
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Age and Gender Effects on Strain Response and Biomechanical Performance of C57BL/6 Mice
… is a systemic skeletal disease resulting in low bone mass and micro architectural deterioration of bone tissue. It causes a consequent increase in bone fragility and susceptibility to fracture. This age-related bone loss is a major healthcare problem nowadays. Due to this fact, ability to …
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Hip fracture - Mortality and residual lifetime risk of fractures
… is the most severe clinical manifestation of bone fragility. Hip fracture predominantly affects an already frail population and is associated with multi-cause morbidity and high mortality. Improved knowledge of long-term outcome is essential in order to improve future care and prevention of …
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MUSCULOSKELETAL STRENGTH, FALL AND FRACTURE RISK IN EARLY POSTMENOPAUSAL WOMEN
… gait speed, fracture risk assessment, as well as bone quality assessment using peripheral quantitative computer tomography (pQCT) and dual x-ray absorptiometry (DXA). Results: Fall-risk status (strength, balance, mobility) gradually improved over the first year post-fracture, with balance …
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Bone Regeneration Potential of Mesenchymal Stromal Cells derived from a Clinically Relevant Rat Model of Osteoporosis
… with these fractures, characterized by reduced bone mass, increased bone fragility. There exists a high failure rate in the translation of treatments to osteoporotic populations. Mesenchymal stromal cell (MSC) transplantation as a therapeutic strategy for OP has not yet been examined in clinical …
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Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
… mellitus is correlated with modifications in bone microarchitectural and mechanical strength, leading to increased bone fragility. The incretin hormones, with a classical effect to increase insulin secretion following food ingestion, are now postulated to have important direct effects on bone. …
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In Vitro Regulation of Ptgs2 and Nos3 Expression in Clonal Osteogenic Cells Following Pulsatile Fluid Flow
… is a major health problem characterized by low bone mass and microarchitectural deterioration leading to enhanced bone fragility and increased fracture risk. In contrast, the high bone mass trait is characterized by increased bone mass and strength, with a significantly decreased fracture risk. …
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Mechanically driven In vivo Osteocyte Ca2+ Signaling: Aging and Pharmacologic Effects
<p>Bone’s ability to respond and adapt to mechanical loading declines significantly with age which is a major contributor to bone fragility. It is widely accepted that osteocytes are the key cells responsible for orchestrating the development of the “ideal” skeleton. This ability is attributed to …
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The Role of Annexin A6 in Osteoporosis
… disease which is characterized by decreased bone mass, microarchitectural deterioration of bone tissue and impaired bone strength, thereby leading to enhanced risk of bone fragility. In this study, we aimed to discover a novel herbal therapeutic drug for effective osteoporosis treatment and …
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Influence of Oral Contraceptives on Bone Adaptations to Isokinetic Strength Training in Young Women
… disease of the skeleton characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility and an increased susceptibility to fractures of the hip, spine, and wrist. Current data suggest that at present time, 7.8 and 21.8 million women have osteoporosis and …
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Densidade mineral óssea e propriedades mecânicas de fêmur de ratos submetidos à hipocinesia dos membros pélvicos e a diferentes programas de reabilitação
Durante a ausência de carga no esqueleto, e mesmo em curtos períodos de atividade física diminuída, pode ocorrer enfraquecimento ósseo. Assim, tratamentos médicos comuns para doenças músculo-equeléticas que envolvam imobilização temporária por meio de talas, repouso forçado ou tração aumentam o …
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Effects of Exercise and Traditional Chinese Medical Modalities on Bone Structure and Function
Bone loss often leads to osteoporosis. This is a disease characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. Osteoporosis is a complicated syndrome whose treatment and prevention crosses …