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Showing 1 to 5 of 5 for “"Bond Cleavage Reactions"”.

  1. Designed Bond Cleavage Reactions for Next-Generation Therapeutics

    … first project focuses on a metal-mediated amide bond-cleavage reaction from a pentenoic group by using Au salt (Na[AuCl4]) for prodrug activation in aqueous systems. Central to this strategy is a cyclisation step involving the formation of a 5-membered ring intermediate that undergoes rapid …

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  2. Metal Mediated Mechanisms of Drug Release

    … towards the development of bioorthogonal bond-cleavage reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or “decaging” reaction which can cause a propargyl carbamate to decompose and …

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  3. CHEMICAL BIOLOGY STRATEGIES FOR THE FORMATION AND CLEAVAGE OF CHEMICAL BONDS

    … better understanding of how specific chemical bonds can be either formed or broken gives chemical biologists opportunities to control and regulate these processes with high precision. Therefore, with growing importance of the field of chemical biology, expansion of the toolbox of available …

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