Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Bolus administration"”.
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Effects of cellular and tissue pharmacokinetics on control released growth factors
… on the potency of sustained release versus bolus administration of two growth factors that differed by intracellular trafficking kinetics. Sustained delivery potency was demonstrated to be dependent on both ligand and receptor trafficking and could be predicted based on trafficking …
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Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis
… cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and non-pharmacological interventions to reduce the incidence of FIC. We searched for randomized controlled trials comparing …
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Investigations into the use of continuous low-level medication for the control of helminths in the ruminant
… bis (3-thioallophanate)]. A new concept of administration was investigated, namely continuous low-level anthelmintic medication. Two aspects were studied which divide conveniently into two sections. In Section 1, following preliminary trials undertaken to assess the low-level anthelmintic …
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COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
… feces, and tissues). Following an intravenous bolus administration, DZNep had a dose-independent tri-exponential disposition profile with a short plasma elimination half-life (1.1 h) in SD rats. DZNep also showed a low protein binding in plasma (18.5 %) and a low partitioning to erythrocyte …
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Analysis, pharmacokinetics, metabolism and pharmacodynamics of labetalol in pregnant and nonpregnant sheep
… pregnant sheep following a 100 mg i. vbolus. Labetalol was measured by a sensitive microbore high-performance liquid chromatographic assay with fluorescence detection, developed in this laboratory. The maternal total body clearance was 30.8 ± 3.83 in Umin/kg (mean ± SEM), elimination …
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Apolipoprotein biosynthesis and turnover in mammalian small intestine
… lipoproteins, especially chylomicrons: acute bolus administration of lipid into the gut; overnight feeding of fat-enriched food; and chronic (six week) fat feeding. Using specific antisera and immuno-precipitation techniques, apo B-48 and two other principal intestinal apolipoproteins were …