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Showing 1 to 20 of 44 for “"Bmp signaling"”.

  1. Probing early human embryonic development to characterize BMP signaling stimulators

    Franck, OleChristian-Albrechts-Universität zu Kiel

    Bone morphogenetic proteins (BMPs) sind sowohl in der Embryonalentwicklung als auch im adulten Organismus von entscheidender Bedeutung. Da ein fehlregulierter Signalweg mit zahlreichen chronischen und schwerwiegenden Krankheiten assoziiert ist, stellt dessen Modulierung einen vielversprechenden …

    cau-kiel Repository record

  2. Spatio-temporal investigation and quantitative analysis of the BMP signaling pathway

    Schul, DanielaUniversität Würzburg

    Bone Morphogenetic Proteins (BMPs) are key regulators for a lot of diverse cellular processes. During embryonic development these proteins act as morphogens and play a crucial role particularly in organogenesis. BMPs have a direct impact on distinct cellular fates by means of …

    wurz-thes Repository record

  3. BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality

    Danesh, Shahab Malekpour2010

    … Various bone morphogenetic proteins (Bmps) and Bmp receptors (Bmprs) are expressed in the pancreas and in the tissues that flank the pancreatic bud during pancreatic development. Bmp7, BmpR1a, and BmpRII are expressed in the pancreatic endoderm during pancreatic bud development. Bmp2, …

    utswmed Repository record

  4. BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility

    Sanchez, Angelica2019

    … recent GWAS study [3] identified association of BMP7 with testicular dysgenesis syndrome; however the molecular mechanisms behind this association remain unknown. Previously, we described the development of testicular germ cell tumors in zebrafish carrying a mutation in bmpr1bb, a BMP family …

    utswmed Repository record

  5. THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS

    Singbrant, SofieDepartment of Molecular Medicine and Gene Therapy, Lund University2009

    … candidates, Bone Morphogenetic Proteins (BMP) and Endoglin in adult hematopoiesis. Several publications have described the importance of BMP signaling in specification of hematopoietic tissue in developing embryos. In Article I and II, we investigate the full role of BMP signaling in adult …

    lund Repository record

  6. Body Size Regulation via BMP Signaling in <i>Caenorhabditis elegans</i>

    Madaan, UdayThe Graduate School and University Center of The City University of New York2017

    … a homolog of Bone Morphogenetic Proteins (BMP) is a major regulator of body size; functional loss of DBL-1 leads to a small body size. Due to a drastic change in body size in dbl-1 mutants, we have the advantage of studying body size as a monogenic trait and we are able to investigate the …

    cuny-grad Repository record

  7. Bmp-Signaling Regulates A Common Transcriptional Program to Control Facial Form and Skeletal Morphogenesis

    Bonilla-Claudio, Margarita2011

    … neural crest (CNC) derived progenitor cells. Bmp-signaling plays critical roles in normal craniofacial development, and Bmp4 deficiency results in craniofacial abnormalities, such as cleft lip and palate. We performed an in depth analysis of <em>Bmp4</em>, a critical regulator of development, …

    uthsc Repository record

  8. Not Black and White: BMP Signaling Drives Melanocyte Differentiation Downstream of Stem Cell Activation

    Infarinato, Nicole Rai

    … into mature pigment-producing melanocytes. The signaling factors and gene expression programs that orchestrate these cellular changes are still incompletely understood. To elucidate new insights into this process, I developed fluorescence-activated cell sorting strategies to isolate quiescent, …

    rockefeller Repository record

  9. A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells

    Lim, Daniel A

    … SVZ. I show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells and that SVZ cells express BMP s as well as their receptors. In vitro, BMP signaling potently inhibited neurogenesis. Conversely, Noggin protein in vitro promoted neurogenesis. Overexpression of …

    rockefeller Repository record

  10. Investigating the coordination of germline stem cell fate by ecdysone signaling and BMP signaling in the Drosophila ovary

    Warren, Alexandria IvanaEast Carolina University2025

    … how signal convergence is achieved. Ecdysone signaling and Bone Morphogenetic Protein (BMP) signaling are well-known signals that promote GSC self-renewal. Over-expression of Ecdysone Receptor (EcR), knock-down of bag of marbles (bam), or over-expression of constitutively active thickveins …

    ecu Repository record

  11. Identification of a Novel Role of BMP Signaling in Enteric Neural Crest Colonization of the Zebrafish Enteric Nervous System

    Moore, Joshua AlanRice University2023

    … and we still have much to learn regarding the signaling factors that regulate ENCC development. Here in zebrafish, through transcriptomic, in situ transcript expression, immunohistochemical analysis, and chemical attenuation, I identified a time-dependent role for bone morphogenetic protein …

    rice Repository record

  12. Development of BMP type I receptor kinase inhibitors for the treatment of fibrodysplasia ossificans progressiva and the study of the BMP signaling pathway

    Mohedas, Agustin HumbertoMassachusetts Institute of Technology2014

    The BMP signaling pathway is essential for embryonic development and the maintenance of tissue homeostasis. Dysregulated BMP signaling, both loss and gain-of-function, has been demonstrated in the pathogenesis of diseases including cancer, atherosclerosis, anemia and particularly hereditary …

    mit Repository record

  13. An investigation into a role for follistatin in early cardiogenesis in Xenopus Laevis

    Yong, Zhao2007

    … follistatin gene expression and decreasing BMP signaling. Using cultured explants of the heart region, we demonstrated that addition of BMP4 and activin rescued the inhibitory effects of follistatin and RA on cardiomyocyte differentiation. These results indicate that the increased …

    uwo Repository record

  14. A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish

    Neumann, Joanie2010

    … animals. Alk6b is a member of the TGF-beta/BMP superfamily of receptors. BMP signaling has diverse roles including regulation of cell proliferation, differentiation, embryonic development, germ cell specification and gonadogenesis. Misregulation of the BMP signaling pathway has been …

    utswmed Repository record

  15. Drosophila Cyclin J And The Somatic Pirna Pathway Cooperate To Regulate Germline Stem Cells

    Albosta, Paul Michael2015

    … egg chamber packaging in part by limiting BMP signaling and the accumulation of excess germline stem cells (GSCs) and that CycJ appears to cooperate with the somatic piRNA pathway. The increase of GSCs in armi, piwi, or CycJ double mutants depends on increased BMP signaling. Finally, CycJ …

    wayne-thes Repository record

  16. Fop-Acvr1 Signals By Multiple Modalities In The Developing Zebrafish

    Allen, Robyn S2019

    … in the GS or kinase domains of the type I BMP/TGFβ cell surface receptor, ACVR1, which over-activate signaling through phospho-Smad1/5 (pSmad1/5). To investigate the uncertain mechanism by which FOP-ACVR1 enhances pSmad1/5 activation, we used a zebrafish embryonic dorsoventral (DV) …

    penn Repository record

  17. Zebrafish Cardiac Development Requires a Conserved Secondary Heart Field

    Hami, Danyal2011

    … I further show that differentiation, induced by Bmp signaling, occurs in this progenitor population as cells are added to the heart tube. Some molecular pathways required for SHF development in birds and mammals are conserved in teleosts, as Nkx2.5 and Nkx2.7 as well as Fgf8 regulate Bmp …

    duke Repository record

  18. Differential expression and phenotypic activities of osterix in equine mesenchymal stem cell populations

    Herzog, Kalyn K.University of Illinois at Urbana-Champaign2019

    … 2 (RUNX2) and Osterix (OSX), with interplay from signaling pathways such as the Bone Morphogenetic Protein (BMP) network. MSCs isolated from bone marrow (BM) and adipose tissue (ADI) are most commonly utilized in human and veterinary regenerative medicine applications. BM-MSCs have shown superior …

    uiuc Repository record

  19. Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions

    Piccioli, Zachary D. (Zachary David)Massachusetts Institute of Technology2014

    … that rapid bouton budding requires retrograde BMP signaling and local alteration in the presynaptic actin cytoskeleton. BMP acts during development to provide competence for rapid synaptic growth by regulating the levels of the Rho GEF trio, a transcriptional output of BMP-Smad signaling. In a …

    mit Repository record

  20. Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons

    James, Rebecca E.Case Western Reserve University School of Graduate Studies2013

    … and remodeling of synapses. Defining the signaling pathways that underlie such plasticity has been a major goal of modern neuroscience. BMP signaling critically regulates both morphological plasticity and neurotransmission in motorneurons at the Drosophila neuromuscular junction (NMJ). …

    ohiolink Repository record

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