Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Bmi-1"”.
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The function of E2F6 in the Polycomb complex
… of its members, including the oncoprotein Bmi 1, appear to repress the transcription of p1 6INK4A and pI 9 ARF. In order to determine the biological function of E2F6, we have generated and characterized E2f6'- mice and mouse embryonic fibroblasts (MEFs). The mutant mice are viable and …
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Study of Rest As A Negative Regulator of P16Ink4A
… transcription by the polycomb protein Bmi-1, and its negative regulation by <em>microRNA-203</em> (<em>miR-203</em>) and our identification of a <em>RE1 </em>element in the downstream regulatory region of <em>miR-203, </em>we asked if the p16<sup>Ink4a</sup> expression was controlled by …
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Discovery and Characterization of the Polycomb Repressive Complex 1 of C. Elegans
… I describe here that MIG-32 is a homolog of BMI-1, a core component of PRC1. I also identify SPAT-3A as a homolog of Ring1B, a partner protein of BMI-1 in the PRC1 core complex. Mig-32 and spat-3 mutants have some defects that overlap with those of mes mutants. However, unlike the mes …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… We discovered that MDM2, BMP7 and Bmi-1 were overexpressed in the tumorigenic HPDE cells, and that Smad4 played important roles in regulation of BMP7 and Bmi-1 gene expression and the tumorigenic transformation of HPDE cells. IPA signaling pathway analysis of microarray data …
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Evaluation of prognostic markers for oropharyngeal carcinoma using tissue microarray
… and biomarkers expressed by stem cells: Bmi-1, HESC5:3, and HES77 in a cohort of 202 OPSCC patients. We also examined the correlations of these markers with HPV infection. We found that high TLR5, low TLR7, and high PR levels are associated with poor disease-specific survival (DSS) …
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E2F6 in axial skeletal development and gliosis
… Mice deficient for both E2f6 and Bmil, a component of PRC1, exhibit increased penetrance of axial skeletal transformations. Thus, E2F6 and Bmil cooperate in the regulation of Hox genes and axial skeletal development. Bmi 1 also represses transcription of the Ink4a-Arf locus, and it …
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Regulation and patterning of cell differentiation and pluripotency
… simian virus 40 large T antigen (TAg), or with Bmi-1 followed by the human telomerase reverse transcriptase (hTERT) gene; the cells were expanded; and the transduced genes were removed by adenoviral vector expressing Cre recombinase. The TAg gene was more efficient in cell transduction than the …
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Resident angiogenic mesenchymal stem cells from multiorgan donor thoracic aortas
… cell markers, e.g., OCT4, c-kit, BCRP-1, IL6 and BMI-1. As previously documented using bone marrow derived MSCs, resident vascular wall MSCs were able to differentiate in vitro into endothelial cells in the presence of low-serum supplemented with VEGF-A (50 ng/ml) for 7 days. Under the condition …
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Prevalence of overweight and obesity in children aged 5 to 6 years exposed to Gestational Diabetes Mellitus complicated pregnancies in the Western Cape, South Africa
… measured by their age-specific body mass index (BMI) and Z-scores. Additionally, the association between other risk factors, overweight and obesity was investigated. Methods: A cross-sectional sub-study design was employed nested within a larger study that is investigating the progression to type …
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Sensitivity to chemical stimuli plays a fundamental role in the food preferences. Examples in the evolutionary scale: 1. Role of the walking leg chemoreceptors in the red swamp crayfish Procambarus Clarkii 2. PROP bitter taste sensitivity and its nutritional implications in Humans
… to other oral stimuli, food preferences and BMI, while other studies did not confirm this association. It is known that PROP phenotype is associated with variant in bitter taste receptors TAS2R38 and with density of fungiform papillae on tongue surface. Although most of PROP phenotypic …