Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Blood-brain barrier permeability"”.
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Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
… hypothesized that activation of AQP4 may mediate permeability of the CNS during systemic inflammation. Here, mice were i.v. injected with fluorescent tracers of low (1 kd) and intermediate (10 kd) molecular weights 24 hours after induction of endotoxemia with i.p. LPS. Fluorescent microscopy using …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… are incompletely understood. Both increased blood-brain barrier (BBB) permeability and inflammation have been suggested to play a role. We hypothesised that BBB permeability and microglia activation would be increased in SVD and explored the relationship between these processes and other …
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Peptide-Functionalized Layer-by-Layer Nanoparticles Demonstrate Improved Blood Brain Barrier Permeability for Glioblastoma Treatment
… in the treatment of glioblastomas is the blood-brain barrier (BBB), the endothelial cells that line the vessels of the brain and are stitched together into a barrier by tight junction complexes. One approach to overcoming this barrier is encapsulating drugs in nanoparticles whose surfaces …
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The Effects of Blast-Induced Neurotrauma on Blood-Brain Barrier Permeability, Cell-Cell Junction Protein Levels and the Role of Peroxynitrite
Traumatic brain injury is one of the most common injuries presented in emergency departments in the U.S.. While mild traumatic brain injury (TBI) is often not reported or treated it may still result in significant pathophysiological disruptions for the patient. As a result of the ongoing military …
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Disease mechanisms and markers of progression in cerebral small vessel disease
… clinical sequelae, and I further tested whether brain lesion volume can regress over time. In part II I investigated the role of two novel pathophysiological mechanisms (inflammation and the permeability of the blood-brain barrier), and their relationship with SVD severity and progression. …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… molecules with inherent antitumor activity, blood-brain barrier permeability, and capability for tumor-specific drug deliverance and intraoperative visualization (termed <em>theranostic)</em> were of focus. Confocal microscopy was employed to characterize<em> in vitro </em>specificity of …
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… detected in the central nervous system, reduce brain infarction volumes, and improve neurological behavior tests 24 hours after HIE. Administration of G-CSF was able to play a pivotal role in attenuating neuroinflammation and BBB disruption 48 hours following HIE. Similarly, OPN was able to …
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On Brain Oedema
Traumatic brain injury and bacterial meningitis may at a glance appear as two different disease entities. The host reaction, however, to both trauma and infection involves a strong inflammatory response, with the classical symptomology of rubor, tumor, calor, dolor et functio laesa. Tumor, …
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Passive Acoustic Mapping of Microbubbles in Focused Ultrasound Induced Brain Therapies for Preclinical Studies
Safe and targeted agent delivery to the brain is critical in developing new therapies for highly prevalent brain disorders. Microbubble (MB) - mediated, focused ultrasound (FUS) can temporarily modulate blood-brain barrier permeability (BBBM) to enhance local agent delivery. To explore new brain …
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Systemic inflammatory regulation of blood-brain barrier inflammation
The endothelial cells of the blood-brain barrier are essential for the maintenance of homeostasis in the central nervous system. These cells act as a physical and transport barrier, restricting the movement of systemic immune cells and blood components into the brain. The physical barrier is …
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Development of imidazotetrazines for the treatment of glioblastoma & as synthetic precursors to diazo species
… aggressive, and deadly form of malignant brain tumor with only 10% of patients surviving five years. The current standard treatment for GBM patients is bulk surgical resection and radiotherapy with concomitant and adjuvant temozolomide (TMZ), a small molecule DNA alkylating agent. The …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ANTIPARASITIC AND ANTICANCER AGENTS
… to enhance potency, drug-like properties, and blood-brain barrier permeability. Our investigations revealed that 1,3,4-oxadiazole derivatives exhibited broad- spectrum antiparasitic activity. In contrast, 1,2,4-oxadiazole derivatives displayed enhanced efficacy against T. brucei and Leishmania. …
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Astrocyte-mediated immune modulation during mycobacterial infection
… through flow cytometric analysis of infected brain cells. The novel findings presented here collectively demonstrate the sophistication and complexity of astrocyte activity and behaviour during host immunity. For the first time, astrocytes showed internalisation of M. bovis BCG and M. …
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The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
… (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) based diagnostic and therapeutic applications. Bimetallic gold-platinum nanoparticles (AuPtNPs) have recently attracted great attention for …
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Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
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Design and synthesis of novel non peptidomimtic beta-secretase inhibitors in the treatment of Alzheimer's disease
… accumulation of β-amyloid peptide (Aβ) in the brain is a major factor in the pathogenesis of AD. Aβ is formed by initial cleavage of β-amyloid precursor protein (APP) by β-secretase, therefore BACE1 inhibition represents one of the therapeutic approaches to control progression of AD, by …
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Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… disease (CSVD) affects small vessels in the brain and is a major contributor to stroke and vascular cognitive impairment (VCI). Although VCI poses a significant public health burden, the underlying biological processes and mechanisms remain poorly understood. The pursuit of this avenue of …