Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Blood-brain barrier disruption"”.
-
Technique for Repeatable Hyperosmotic Blood-Brain Barrier Disruption in the Dog
Reversible hyperosmotic blood-brain barrier disruption (BBBD) has been used in pharmaceutical research as well as human medicine to enhance drug delivery across the blood-brain barrier. However a technique for repeatable BBBD in the canine has not been described. This study describes a repeatable …
-
EphA4 Influences Blood Brain Barrier Disruption and Endothelial Cell Response following Traumatic Brain Injury in a Mouse Model
… related disabilities are attributed to traumatic brain injury (TBI) in the United States per year. Due to the unforeseeable nature of TBI and its association with the sequelae of other neurological comorbidities, research is centered around the secondary responses of brain mechanisms proceeding …
-
Multi-parametric photoacoustic/ultrasound localization (PAUL) imaging and its applications
… monitoring of focused ultrasound–induced blood–brain barrier disruption, longitudinal assessment of renal microvascular dysfunction in acute kidney injury, and image-guided mechanochemical cancer therapy. Overall, this work establishes PAUL imaging as a high-resolution, versatile, and …
-
Investigating Injury Pathology of Blast-induced Polytrauma and Assessing the Therapeutic Role of Hemostatic Nanoparticles after Blast Exposure
… can cause barotrauma to the lungs and the brain. Blast-induced mild traumatic brain injury has been labeled the "signature wound" of current military conflicts in Iraq and Afghanistan (Snell and Halter 2010). In addition to elevated number of blast-induced traumatic brain injuries due to …
-
Seeing Inside a Concussion: The Role of Microglia in Maintaining the Blood-Brain Barrier in Repetitive Mild Traumatic Brain Injury
Concussion, or mild traumatic brain injury, is a common type of brain injury that can cause significant debilitating symptoms despite no evidence of brain damage on common diagnostic imaging modalities. Repetitive concussion has recently come into focus in the public eye and among scientists as …
-
Modulation of Alzheimer’s Disease Pathology by Collagen-Induced Rheumatoid Arthritis in APP/PS1 Mice
… of APP/PS1 mice, which correlated with increased blood brain barrier disruption, Iba-1 or Mac-1 positive microglia, and CD45-positive microglia/macrophages. In contrast, CIA reduced survival and vessel density and length with features of cerebrovascular pathology including vascular segments, …
-
Radiation effects on the blood-brain barrier
… compounds are restricted to the lumen of the blood vessel, the resulting high-LET alpha and lithium particles cannot deposit their energy in the normal cells beyond the vasculature after the target is exposed to thermal neutrons. This allows for a 2- to 3-fold increase in the calculated dose …
-
Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
… mechanics. Here, we investigate the mechanics of brain and brain cancer cells, specifically focusing on how PEFs impact cell mechanics and PEF-induced blood-brain barrier disruption. In our first study, we investigate single-cell mechanical disruption of glioblastoma cells after reversible …
-
Modeling subconcussive and cumulative subconcussive impacts using a lateral fluid percusion injury device
… developed a novel animal model of subconcussive brain injury (scTBI) paradigm and the effects of cumulative intra-day scTBI utilizing a digitally controlled fluid percussion injury device (dcFPI). Acute behavioral effects of cumulative 5x scTBI resulted in longer duration in latency of righting …
-
Antioxidant Biomarkers and Nutraceutical Therapeutics in Neurodegeneration and Neurotrauma
<p>Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal …
-
Methods and algorithms for quantitative analysis of metallomic images to assess traumatic brain injury
… determine the link between traumatic brain injury (TBI) severity and chronic traumatic encephalopathy (CTE) neuropathology, specifically looking into the role of blood-brain barrier disruption following TBI. In order to causally investigate the relationship between the tau protein …
-
Enhanced Delivery of Gold Nanoparticles with Therapeutic Potential for Targeting Human Brain Tumors
The blood brain barrier (BBB) remains a major challenge to the advancement and application of systemic anti-cancer therapeutics into the central nervous system. The structural and physiological delivery constraints of the BBB significantly limit the effectiveness of conventional chemotherapy, …
-
The role of Substance P in chronic traumatic encephalopathy
… sports and exposure to repetitive mild traumatic brain injury (rmTBI). CTE has attracted significant attraction over the past few years due to the high incidence of sports-related head injuries and the emergence of dementia-like symptoms many years following active play. In addition, patients with …
-
Effects of Sex and Aging in the Response to Global Cerebral Hypoperfusion
… of all dementia cases. Reductions in cerebral blood flow from intracranial and extracranial atherosclerosis increase VCID risk, even in the absence of overt clinical or imaging evidence of stroke/embolization. The pathology seen in patients with chronic cerebral hypoperfusion, such as …
-
The Origin of Multiple Sclerosis Revisited: The Case for a Soluble Toxin
… is a neurotoxin with a unique tropism for the brain tissues that are specifically damaged during acute MS exacerbations, the blood-brain barrier and the myelin sheath. Using a Western blot seroreactivity assay, I have identified a 10-fold increase in anti-ETX seroreactivity when comparing MS …
-
Advancements in the Treatment of Malignant Gliomas and Other Intracranial Disorders With Electroporation-Based Therapies
The most common and aggressive malignant brain tumor, glioblastoma (GBM), demonstrates on average a 5-year survival rate of only 6.8%. Difficulties arising in the treatment of GBM include the inability of large molecular agents to permeate through the blood-brain barrier (BBB); migration of highly …
-
Combinatorial Treatments and Technologies for Safe and Effective Targeting of Malignant Gliomas Using High-Frequency Irreversible Electroporation
… (GBM) is a highly aggressive and prevalent brain tumor with an average 5-year survival rate of approximately 6.9%. Its complex pathophysiology, characterized by the capacity to invade surrounding tissues beyond the visible tumor margin, intratumor heterogeneity, hypoxic core, and the …
-
A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model
This thesis project serves to fill experimental gaps needed to advance the goal of performing pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, …
-
Overcoming therapeutic resistance in glioblastoma using novel electroporation-based therapies
… common and deadliest of the malignant primary brain tumors in humans, with a reported 5-year survival rate of only 6.8% despite years of extensive research. Failure to improve local tumor control rates and overall patient outcome is attributed to GBM's inherent therapeutic resistance. Marked …