Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 174 for “"Blood-Brain Barrier (BBB)"”.
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Utilizing the Immunomodulatory Effects of Electroporation for Treating Brain Tumors
Brain tumors are among the most devastating types of solid tumors to treat. Standard of care for glioblastoma (GBMs), the most aggressive form of primary brain tumors, has failed to improve the current survival rates in the past decades. Despite many other solid tumors, recent advances in cancer …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… oxidative stress and cellular damage. The blood‐brain barrier (BBB) prevents most pharmaceuticals from entering the brain, therefore, to enable the advancement of potential antioxidant and iron chelator therapies for PD, limiting factors such as brain penetrance and bioavailability need to …
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Role of the Vitamin D Receptor in MDR1/P-glycoprotein Regulation at the Blood-brain Barrier
The blood-brain barrier (BBB) presents a major obstacle for drugs targeting the brain. Drugs that are small or lipophilic enough can penetrate the physical barrier, but are commonly effluxed back into the blood by transporters that are expressed at the luminal membrane, notably P-glycoprotein …
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MOLECULAR TROJAN HORSES IN THE TREATMENT OF METACHROMATIC LEUKODYSTROPHY
… exists and development is hampered by the blood-brain barrier (BBB). I have successfully generated fusion proteins using an ApoE fragment as a molecular Trojan horse fused to the full-length human ASA. These proteins were expressed in eukaryotic cells transduced with lentiviral expression …
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Development and characterisation of a human in vitro model of the Neurovascular Unit using a biomimetic tissue engineered system
… plays an essential role in regulating cerebral blood flow and maintaining the integrity of the blood-brain barrier (BBB). Over the years, several tissue engineering approaches modelling the NVU *in vitro* have gained popularity as they offer a platform to investigate the cellular cross-talk, …
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A Model for Studying Vasogenic Brain Edema
… proven method for targeted drug delivery to the brain that circumvents the blood-brain barrier (BBB). Little study has been conducted in understanding CED in pathological brain states. This is of importance when dealing with chemotherapeutic agent delivery to brain tumors, where vasogenic edema …
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Head Trauma Release of Histamine from Dural Mast Cells Alters Blood-Brain Barrier: Attenuation with Zolantidine
… in trauma-induced increased permeability in the blood-brain barrier (BBB). A single line was scored partially through the left dorsal parietal skull. Immediately following the trauma, degranulation was seen in 39% of the MCs on the left and in 2% on the right. After a 20 min survival period, left …
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Exploring Interactions Between Malignant Brain Cancer Cells and the Tumor Microenvironment Following High-Frequency Irreversible Electroporation
… and clinical utility as a therapeutic for brain tumors, including gliomas. H-FIRE has been shown to induce precise, uniform ablation within the tumor tissue, as well as local changes to the tumor microenvironment and systemic changes to the immune landscape. Namely, disruption of the …
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Synthesis, characterization and biological studies of carboranyl-porphyrin bioconjugates for treatment of brain tumors
<p>Chapter 1 gives a brief introduction to brain tumors, approaches to deliver drug across the blood brain barrier (BBB), boron neutron capture therapy (BNCT) for brain tumors, application of carboranyl derivatives in attempt to treat brain tumors using BNCT. Chapter 2 involves synthesis, …
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Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
… drugs to therapeutic levels in vivo across the blood-brain barrier (BBB). It was not yet known, however, whether such particles could also be taken up by neurons and other brain cells. Here we report the novel use of polybutylcyanoacrylate nanoparticles (NPs) for delivery of intact, functional …
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Focused ultrasound-mediated drug delivery to the brainstem
<p>Brainstem gliomas are tumors that occur in the brainstem, the brain region that connects the brain to the spinal cord and controls vital body functions. The critical anatomic location of the brainstem precludes surgical intervention and limits the use of invasive therapeutic techniques. …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
The central nervous system (CNS) includes the brain and spinal cord, where both possess a blood to brain and a blood to cerebrospinal fluid (CSF) barrier. The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) regulate the passage of many molecules to maintain and protect these sensitive …
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Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
… consolidate the apical surface of adjacent brain microvascular endothelial cells (BBMvEC’s) creating the blood-brain barrier (BBB), a critical regulator of CNS homeostasis. Junctional disassembly and barrier dysfunction are established features of cerebrovascular diseases (e.g. stroke) …
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Peptide-Functionalized Layer-by-Layer Nanoparticles Demonstrate Improved Blood Brain Barrier Permeability for Glioblastoma Treatment
… in the treatment of glioblastomas is the blood-brain barrier (BBB), the endothelial cells that line the vessels of the brain and are stitched together into a barrier by tight junction complexes. One approach to overcoming this barrier is encapsulating drugs in nanoparticles whose surfaces …
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Development of a physiologically accurate 3D blood-brain barrier hydrogel model
The blood-brain barrier (BBB) is a tightly interconnected network of cells that creates a semi-permeable barrier between the central nervous system and the rest of the human body, taking in nutrients and blocking/excreting waste/potentially toxic chemicals from the brain, maintaining the brain's …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… nervous system (CNS) diseases is limited by the blood-brain barrier (BBB), a selective vascular interface restricting passage of most molecules from blood into brain. Specific transport systems have evolved allowing circulating polar molecules to cross the BBB and gain access to the brain …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… AT AUTHOR'S REQUEST.] Traumatic brain injury (TBI) is a highly prevalent cause of death and disability in the US and has become a significant burden to our present healthcare system. Currently there are few biomarkers and clinical diagnostic tests to determine the severity of TBI …
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Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
Disruption of the blood-brain barrier (BBB) is hypothesized to play an important role in the disease biology of schizophrenia (SZ). Brain microvascular endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which …
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hiPSC-Derived Cerebral Small Vessel Disease Models
… affect the small perforating arteries of the brain and is a major cause of stroke and dementia worldwide, but its pathology is yet to be known. We hypothesise that the integrity of the blood brain barrier (BBB) is disrupted and could contribute to increased BBB permeability. Evidence also …
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Towards brain-wide noninvasive molecular imaging
… interplay of signaling molecules underlies brain activity, yet studying these molecular events in living whole organisms remains a challenge. Magnetic resonance imaging (MRI) is the most promising imaging modality for development of molecular signaling sensors with deeper tissue penetration …
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