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Showing 1 to 20 of 35 for “"Blood clots"”.
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Graphical and Bayesian Analysis of Unbalanced Patient Management Data
… Ratio (INR) measures the speed at which blood clots. Healthy people have an INR of about one. Some people are at greater risk of blood clots and their physician prescribes a target INR range, generally 2-3. The farther a patient is above or below their prescribed range, the more dangerous …
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The Mechanical Properties of Individual Electrospun Fibers and Fibrin Fibers
… matrix and tissues such as bone, cartilage and blood vessels, to name a few. Fibrinogen, a plasma protein, is converted into fibrin fibers which form the mechanical and structural support for blood clots. Biomimetic nanofibers can be synthesized outside of the body through the process of …
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Mechanisms of Post-hemorrhagic Hydrocephalus after Germinal Matrix Hemorrhage
… patient population. Thrombin, cerebroventricular blood clots, and iron have been identified as causative factors of hydrocephalus formation. Thrombin stimulates proteinase-activated receptors, leading to subsequent mTOR activation and extracellular matrix protein proliferation, which possibly …
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Computational Studies on the Mechanical Properties of Muscle and Blood Clot Elasticity
… for muscle from the protein titin and for blood clots from the protein fibrinogen. These investigations utilize free dynamics MD to verify experimentally observed conformations of proteins, SMD to probe their response to mechanical forces, and adaptive biasing force (ABF) simulations to …
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Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1
… in deleterious effects on the organism, such as blood clots. Elevated levels of PAI-1 are implicated in a variety of diseases and conditions. We have synthesized a variety of novel, small-molecule PAI-1 inhibitors in order to establish a structure-function relationship throughout the compounds. …
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Resonating Fluidic Circuits: A Novel Technology to Create a Portable Blood Viscoelasticity Measuring Device
… that can diagnose coagulopathy by measuring blood clot viscoelasticity are portable, meaning that coagulopathy can only be diagnosed inside a well-resourced hospital. Resonating fluidic circuits are a promising technology to address this clinical need. In addition to being small enough to fit …
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Roles of coagulation factor XIII in the functions of blood platelets
Haemostasis is initiated following blood vessel injury to preclude loss of blood. It involves concerted actions of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their …
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
… the process that results in breakdown of blood clots. PAI-1 also exhibits effects on various human ailments including atherosclerosis, stroke and diabetes, with which high levels of PAI-1 have been associated. The goal of this research study is to design novel, potent, and specific small …
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Synthesis and structure activity relationship of novel small molecules as inhibitors of plasminogen activator inhibitor-1
… of fibrinolysis, which is the breakdown of blood clots. PAI-1 inhibits serine proteases tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which are key factors in fibrinolysis. Excess levels of PAI-1 have also been shown to increase the risk of diabetes, …
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Measuring the Microscale Mechanical Properties of Fibrin Fibers and Cancer Cells
… Fibrinogen, one of the most abundant proteins in blood, is converted into fibrin fibers that perform the essential mechanical task of stemming the flow of blood. Fibrinogen fibers can be fabricated by a technique called electrospinning. We studied the mechanical properties of dry, electrospun …
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EVALUATING THE USE OF TURBIDIMETRY FOR STUDYING FIBRIN STRUCTURAL PROPERTIES
… fiber mesh forms the structural backbone of blood clots. Many pathological conditions result in fibrin gels with altered structural properties, so there is interest in developing rapid and accurate ways to characterize fibrin features. One method of determining the diameter and mass-length …
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Generating Gaseous Emboli Mimics in an ECMO Flow Phantom
… emboli. These unattached masses of solid blood clots and gaseous air bubbles have the potential to occlude blood vessels and lead to complications such as neurological damage. Existing ultrasound methods for detecting and characterizing them are designed and tested on data sets that often …
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High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice
… is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce …
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Validation of Criteria Used to Predict Warfarin Dosing Decisions
People at risk for blood clots are often treated with anticoagulants, warfarin is such an anticoagulant. The dose's effect is measured by comparing the time for blood to clot to a control time called an INR value. Previous anticoagulant studies have addressed agreement between fingerstick (POC) …
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Healthcare worker's adherence to the use of adult primary care guidelines in management of cardiovascular disease in the North-West Province
… by diseased vessels, structural issues, and blood clots. In this country, Standard Treatment Guidelines are issued to help healthcare workers with diagnosis and management. Given the destructive effects of CVDs, the study's goal was to investigate healthcare workers' adherence to the …
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Predicting Transcatheter Aortic Valve Leaflet Thrombosis Risk Using Pre-Procedural Computed Tomography Angiogram and Computational Modeling
… heart valve due to calcium buildup. It restricts blood flow from the heart and, if left untreated, can lead to irreversible damage to the left ventricle wall and even death. The stenosed aortic valve is usually replaced with a bioprosthetic valve either via open-heart surgery or transcatheter …
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MODELING OF THE CHEMOMECHANICAL INTERACTIONS BETWEEN CELLS AND THE EXTRACELLULAR MATRIX
… evolution of cell redistribution during blood clot contraction. This model demonstrates how mechanosensitive signaling controls ATP hydrolysis in platelets, subsequently leading to cellular reorganization within blood clots. Lastly, we develop a phase field theory-based model to determine …
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Evaluation of Current Thrombophilia Screening Practices of Internists, Family Physicians, and Obstetricians/Gynecologists: Factor V Leiden Genetic Testing and Referral Patterns
… exhibits an increased susceptibility to form blood clots, especially in the veins of the lower extremities. A mutation in the gene encoding for factor V, known as factor V Leiden (FVL), is the most common cause of inherited thrombophilia, and contributes to thrombotic events by altering the …
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Towards Establishing Methods of Synthesis, Purification, and Structural Determination for Human Fibrinogen
Fibrinogen is a prevalent blood-based glycoprotein. In its polymerizable form, fibrin, it serves as the structural component of blood clots and helps to incorporate red blood cells, macrophages, and fibroblasts to the wound-site. Fibrinogen plays important roles in inflammation and tissue …
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