Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"Blood Vessel"”.
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Blood Vessel Development
… Cardiovascular function depends on patent blood vessel formation by endothelial cells. In this dissertation, a careful analysis of different aspects of blood vessel development was conducted in order to expand our understandings of the biology of blood vessel. In brief, Chapter 2 provides …
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Mathematical modelling of transport across blood vessel walls
… degenerative diseases is filtration across microvessel walls. The role of the microvessel wall is to let oxygen and nutrients contained in the blood stream to reach the interstitium, and ultimately the surrounding cells, while blocking macromolecules. An understanding of these processes is …
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… deposition of fibronectin and stiffening of the vessel wall matrix, is found in both older patients and atheroprone regions. The independent effects of these factors on the function of endothelial cells is poorly understood due to the inability to study them in isolation in vivo. The Truskey lab …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
… to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Rho family GTPase proteins and their regulators regulate mammalian vascular …
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The inheritance of retinal blood vessel patterns in man: a twin study
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characteristics of blood vessel wall and atherosclerosis using high frequency ultrasound signals
… called plaque, reduces and eventually blocks the blood flow to the heart muscle, which leads to heart attack and failure. Different techniques such as electrocardiogram, coronary angiography, computer tomography scan and ultrasound exist to diagnose and evaluate the risk and presence of …
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EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
<p>During angiogenesis, the development of new blood vessels from existing vessels, there must be tight regulation between a leading tip cell and trailing stalk cells during vascular patterning. Lateral inhibition produced by Notch signaling is central to the specification and maintenance of tip …
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Implementation of Physiologic Pressure Conditions in a Blood Vessel Mimic Bioreactor System
… of Physiologic Pressure Conditions in a Blood Vessel Mimic Bioreactor System Kevin Mark Okarski Tissue engineering has traditionally been pursued as a therapeutic science intended for restoring or replacing diseased or damaged biologic tissues or organs. Cal Poly’s Blood Vessel Mimic …
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Development and Characterization of Tissue Engineered Blood Vessel Mimics Under "Diabetic" Conditions
<p>The development of tissue engineered blood vessel mimics for the testing of intravascular devices in vitro has been established in the Cal Poly tissue engineering lab. Due to the prevalence of cardiovascular disease in diabetic patients and minimal accessible studies regarding the interactions …
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Pericyte-Endothelial Cell Interactions during Blood Vessel Formation and in Diabetic Scenarios
… changes in the vasculature did not report severe vessel damage or vBM thickening, suggesting that the effects of PC loss occur over a longer period of time. Because the chronic effects of PC loss are more difficult to ascertain, especially in a complex condition such as DR, the mechanisms …
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Detection of Stroke, Blood Vessel Landmarks, and Leptomeningeal Anastomoses in Mouse Brain Imaging
… Anastomoses, are connections between blood vessels originating from different arteries. Despite limited knowledge, they are suggested as an important contributor to cerebral stroke recovery that allows additional blood flow through the affected area. However, few databases and …
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Tissue Engineering a Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing
<p><em>Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing</em></p> <p>Navid Djassemi</p> <p>Tissue engineering blood vessel mimics has been proposed as a method to analyze the endothelial cell response to intravascular devices that are used in …
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Effects of blood vessel permeability on mechanical properties of bone under micro-gravity conditions
… (body weight) is achieved by increasing the blood vessel permeability to increase the transcortical interstitial fluid flow. A method of exposure to bio-frequency spectrum (BFS) light (infrared to micrometer wavelength) was used to increase the blood vessel permeability. We tested the …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
… was on the vasculature, but also on the most blood vessel specific laminin chain, the laminin ?4 chain. Atherosclerosis is an inflammatory process in large and medium sized arteries. During progression of atherosclerosis the vascular smooth muscle cells (VSMC) in the vessel wall become …
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Blood Vessel Segmentation and shape analysis for quantification of Coronary Artery Stenosis in CT Angiography
… diagnostic system. Firstly, an automated vessel segmentation algorithm is developed to extract the coronary arteries based on the framework of active contours. Both global and local intensity statistics are utilised in the energy functional calculation, which allows for dealing with …
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Development and Optimization of Imaging and Image Quantification Techniques for Tissue-Engineered Blood Vessel Mimics
<p>Blood vessels mimics (BVMs) are tissue-engineered blood vessels used to test vascular devices in an environment that mimics some simple anatomical factors of native blood vessels. It is important to accurately and consistently assess tissue-engineered blood vessels, although there is currently a …
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Development of an In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources
… of devices and therapies. Specifically, in-vitro blood vessel mimics (BVM) have been developed to create a bench-top blood vessel model using human cells that can be used to test and evaluate vascular disease treatments and intravascular devices. Previous BVM work has used fat derived human …
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Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging
… pathological as well as tissue engineered blood vessels. The goal of the present study is to develop an imaging system for non-destructive monitoring of blood vessels maturing within a bioreactor. Non-destructive structural imaging of tissue-engineered blood vessels cultured in a novel …
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A Multicomponent Bioactive Tissue-Engineered Blood Vessel: Fabrication, Mechanical Evaluation and Biological Evaluation with Physiological-Relevant Conditions
… vascular grafts in the replacement of small vessels is known to be associated with the lack of physiological signals to vascular cells causing adverse hemodynamic, inflammatory or coagulatory events. Current studies focus on developing engineered vascular devices with ability of directing …
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Characterization and Implementation of a Decellularized Porcine Vessel as a Biologic Scaffold for a Blood Vessel Mimic
… up in the coronary arteries, occluding normal blood flow. Balloon angioplasty procedures in combination with a metal stent often result in successful restoration of normal blood flow. However, bare metal stents often lead to restenosis and other complications. To compensate for this problem, …
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