Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Blood Biomarkers"”.
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Blood Biomarkers of Presymptomatic Frontotemporal Dementia
… plasma-derived miRNAs and proteins as potential biomarkers of presymptomatic FTD. We utilised baseline data from six carriers and 17 controls, alongside longitudinal data from three timepoints with six carriers and 12 controls. Additionally, we optimised a pipeline to investigate plasma-derived …
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Altered cord blood biomarkers in neonatal brain injury
… biochemical measurements. The umbilical cord blood (UCB) can give a snapshot of both the newborn and the in-utero environment. It is non-invasive to both mother and infant and contains microRNA (miRNA), messenger RNA (mRNA) and circulating proteins that can exist stably in the circulation. …
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Novel imaging and blood biomarkers in acute aortic syndrome
… and computed tomography (PET/CT) and circulating biomarkers in patients with acute aortic syndrome. METHODS: We performed 18F-sodium fluoride PET/CT in 56 patients with aortic dissection, intramural haematoma or penetrating aortic ulcers and 20 healthy controls. First, we characterised radiotracer …
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Discovery and validation of novel blood biomarkers of breast and prostate cancer
Identification of novel biomarkers of breast and prostate cancers to supplement current diagnostic, prognostic and predictive tools is an important clinical need. Interaction between the host’s immune system and tumours is reflected in detectable changes in profiles of proteins in blood cells and …
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Effect of dietary protein source on satiety, postprandial blood biomarkers, and metabolism
… diet was made available later in the dark phase. Blood plasma was collected from rats surgically implanted with jugular catheters at baseline and at 30-minute intervals for two hours following test meal ingestion, and analyzed for amino acid and insulin concentrations. Separate cohorts of rats …
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Identification and validation of blood biomarkers to develop effective diagnostic tools for coronary microvascular disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Applications of blood biomarkers of traumatic brain injury across the severity spectrum---a focus on pathophysiological mechanisms
… However, a growing body of evidence suggests blood biomarker analysis may be a useful tool to aid in the elucidation of important pathophysiological mechanisms across a range of severities in human TBI. OBJECTIVE. The aim of this thesis was to use blood biomarkers as a tool to advance …
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The effects of physical function and genetics on cognition and blood biomarkers in individuals at-risk for Alzheimer’s disease and related dementias
… clusters produce better cognitive outcomes and blood biomarker profiles compared to lower functioning clusters among at-risk individuals, (2) Evaluate the ApoE gene’s mitigating effect on physical activity and blood biomarkers, (3) Examine the associations between risk factors and p-tau217. …
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Effects of Peripartal Supplementation of Yeast-Based Products on Performance, Rumen Fermentation Profile, and Circadian Rhythms in Dairy Cows
… 31 to 60 DIM, cows were fed a post-fresh diet. Blood samples and rumen fluid were collected at various time points from −35 to 60 d relative to calving (DRC). Frequent blood and fecal samplings were performed during pre- and postpartum to represent 24-hour circadian rhythms over 3-day periods …
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Population-based prediction of atrial fibrillation
… conventional cardiovascular risk factors and blood biomarkers reflecting diverse pathophysiological pathways to predict onset of AF in the general population.Methods: Individuals with incident AF were identified from a large, population-based cohort study (Malmö Diet and Cancer, n=30 447) …
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Fatigue in Cerebral Small Vessel Disease and its Relationship to Cognitive Behavioural Symptoms
… Disease (SVD) is a disease affecting the small blood vessels in the brain. SVD is a leading cause of both stroke and vascular dementia, whilst cognitive behavioural symptoms such as fatigue are also frequent. Fatigue has a major impact on quality of life, yet little is known about its …
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Development of a prognostic and predictive tool for chemotherapy response in patients with locally advanced and metastatic pancreatic adenocarcinoma
… However, the absence of validated prognostic biomarkers, a lack of consensus on optimal treatment sequencing, and the limited availability of reliable survival prediction tools continue to hinder the implementation of truly personalized care. This doctoral thesis aimed to address several of …
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Multiplatform metabolome profiling to identify specific signatures and biomarkers in blood samples: untargeted approach
… diseases is the need for reliable biomarkers. Thus, new point-of-care diagnostics tools are essential for unambiguously distinguishing diseased patients from healthy ones providing results in rapid time. In this doctoral thesis, an untargeted metabolomics approach based on …
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Peripheral Leukocytes and Intracerebral Hemorrhage
… expansion and cerebral edema. Identifying blood biomarkers associated with neurological deterioration and/or prognosis after ICH is a critical step for developing new therapies. Biomarkers that are mechanistically associated with hemostasis failure or cerebral edema would provide direction …
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The Prediabetes Detection and Physical Activity Intervention Delivery (PRE-PAID) Project
… to have high prevalence rates of T2D. Critical blood biomarkers and measures of physical and physiological fitness were assessed at different time points to ascertain the effectiveness of both community-based physical activity classes and two modes of laboratory-based exercise. The results of …
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An Evaluation of 1) Bone Changes Following Bariatric Surgery and 2) Fat and Muscle Indices Assessed by pQCT: Implications for Osteoporosis and Type-2 Diabetes Risk
… in bone mineral density (BMD), weight loss and blood biomarkers related to bone turnover, hormonal, and nutrient status. Subjects: Nine bariatric surgery patients. Methods: Patients had a DXA bone scan and fasting blood draw at baseline, three, and six months following surgery. Results: RYGB …
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Using Recovery Biomarkers to Evaluate Dietary Compliance in Young Adults Provided Controlled Diets High in Ultra-Processed Foods and Free from Ultra-Processed Foods
… assessment methods, such as urinary recovery biomarkers, offer reliable measures of dietary intake.46 As part of a larger controlled feeding trial, this study utilized 24-hour urinary biomarkers such as sodium, potassium, nitrogen (protein), and phosphorus to assess dietary adherence. …
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Antioxidant Biomarkers and Nutraceutical Therapeutics in Neurodegeneration and Neurotrauma
… severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal degeneration, and resulting neuronal death. These processes deplete the body’s endogenous antioxidant system. …
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Visual Outcome Measures of Remyelination and Neuroprotection in Multiple Sclerosis
… visual acuity, colour vision, oculometry, and blood biomarker measures on approximately 180 people with MS and 30 healthy volunteers across three clinical studies. My findings suggest that there is no single visual outcome measure that should be used in isolation for MS clinical research and …
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The UP AMIGOS project: Testing the predictive validity of the 2007 Pediatric Expert Committee Recommendations in Latinos
… (i.e. height, weight, waist circumference, blood pressure), a physician-conducted history and physical, and venipuncture for blood biomarkers. Analysis. In order to determine prevalence of CVD risk factors, descriptive statistics were run making comparisons in prevalence by sex and weight …
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