Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 185 for “"Blockers"”.
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Investigating calcium channel blockers as antimalarials
… University of Salford identified calcium channel blockers (CCBs) as potential antimalarial agents. A growing body of evidence has demonstrated the importance of calcium within the Plasmodium life cycle. Studies have shown CCBs and calmodulin inhibitors to exhibit antimalarial activity. The …
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Relationship Between Angiotensin Receptor Blockers and Cancer: A Nested Retrospective Longitudinal Cohort Study
<p> Angiotensin receptor blockers (ARBs) are commonly prescribed drugs that have proven benefits among patients with cardiovascular and diabetic diseases. Recently a concern of modest increase in the risk of solid cancers among ARB users was reported. This became controversial, as many experts …
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The Effectiveness of Beta-blockers after Myocardial Infarction in Patients with Type 2 Diabetes
… Databases to determine the effects of beta-blockers after MI in patients with type 2 diabetes, under real-world conditions. New users of antidiabetic agents with MI were identified by prescription records and ICD-9 codes. Drug exposures were determined from prescription records. …
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Quantifying the Risk of Beta-Blockers and Non-Steroidal Anti-Inflammatory Drugs in Asthma
Beta-blockers and non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided in asthma over risk of bronchospasm which may vary according to drug selectivity and duration of administration. This thesis attempts to quantify the risk of beta-blocker and NSAID exposure in asthma by synthesising …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… suggested that chronic treatment with certain β-blockers such as nadolol and ICI 118, 551 was able to attenuate the asthma phenotype in murine models. However, not all β-blockers seemed to work as carvedilol and propranolol did not reduce the asthma phenotype in mice. Further studies in our …
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A systematic review of the blood pressure lowering efficacy of ACE inhibitors and angiotensin receptor blockers for primary hypertension
… ACE inhibitors and angiotensin receptor blockers (ARBs) are two drug classes that, by different mechanisms, inhibit the renin-angiotensin- aldosterone system that regulates BP. As these drugs are widely prescribed for hypertension, it is essential to determine and compare their effects on …
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The Effect of Withdrawal of Angiotensin II Blockers on Serum Creatinine and Potassium in Patients with Chronic Kidney Disease
BACKGROUND: Renin-angiotensin system (RAS) blockers have been used to delay the progression of various renal diseases, but these medications cause hyperkalemia and the elevation of serum creatinine which impede the continuation of the medications. So far, there have been no data which observe the …
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Poly(ethylene glycol)-based open-channel blockers for the acetylcholine receptor : mechanistic and structure-function studies at the single-channel level
… of channel-associated diseases. Open-channel blockers are channel inhibitors that transiently occupy the open pore of ion channels and impede current flow. They have been used in both clinical treatments of diseases and fundamental researches of synaptic transmission. However, the rational …
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A systematic review of outcomes associated with withholding or continuing angiotensinconverting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) prior to noncardiac surgery
Introduction The global rate of major noncardiac surgical procedures is increasing annually, and of those patients presenting for surgery increasing numbers are taking either an angiotensin-converting enzyme inhibitor (ACE-I) or an angiotensin receptor blocker(ARB). The current recommendations …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
Muscarinic acetylcholine receptors (mAChRs) are G-protein-coupled receptors that are underutilized for controlling insect pests despite their involvement in various physiological functions. To-date, there are no commercialized insecticides targeting insect mAChRs. In this dissertation, effective …
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Analysis of RF Front-End Non-linearity on Symbol Error Rate in the Presence of M-PSK Blocking Signals
… signal. We call these adjacent channel signals blockers. Receiving blockers are unavoidable in wideband receivers and their effect must be analyzed and properly addressed. This M.S. Thesis studies the effect of blockers on system performance, specifically the symbol error rate (SER), as a …
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Evaluation of Anion Transporters as Potential Target Sites for Insect and Nematode Control: Toxicological, Electrophysiological, and Molecular Studies
In this study, four anion transporter (AT) blockers, DIDS (4, 4′-diisothiocyanatostilbene-2, 2′-disulfonic acid), 9-AC (anthracene-9-carboxylic acid), NPPB (5-nitro-2-(3-phenylpropylamino) benzoic acid), and IAA-94 (indanyloxy acetic acid) were selected to evaluate ATs as potential target sites for …
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Reconfigurable and Interference-Tolerant Receivers for Next Generation Wireless Systems
… linearity against in-band and adjacent-channel blockers. While widely adopted in modern receiver architectures, these switched-capacitor circuits remain inherently vulnerable to blockers at clock harmonics, due to their hard-switching nature. These blockers, common in 5G bands, pose a key …
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The effects of coronary heart disease, beta-blockade medications and stage duration on graded exercise testing
… healthy (AH; N=8); cardiacs receiving beta-blockers (C-BB; N=8); cardiacs not receiving beta-blockers (Câ NBB; N=lO).
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Adherence to medication in patients with heart failure : effect on mortality and hospitalization
… the risk for death and disability. Beta blockers and ACE inhibitors have become standard treatments in heart failure because clinical trials have demonstrated their beneficial effect on mortality and morbidity in these patients. As not much is known about adherence to these medications, …
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Achievement of secondary prevention goals 6 to 9 months after Acute Coronary Syndrome : a retrospective, cross-sectional analysis
… HMG-CoA reductase inhibitors [statins], beta-blockers and angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers [ARBs]) and smoking cessation in patients after acute coronary syndromes. At present, little is known about adherence to medication and smoking behaviour …
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ABSENCE OF V1AR ALTERS CARDIAC FUNCTION AT BASELINE AND FOLLOWING ACUTE CARDIAC INJURY
… β-adrenergic receptor (βAR) signaling (e.g. β- blockers) or RAAS signaling (e.g. angiotensin receptor blockers/ARBs or angiotensin converting enzyme inhibitors/ACEi’s) Additionally, clinical studies have demonstrated that drugs blocking these neurohormones from properly signaling have decreased …
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The Morbidity & Mortality of Prevalent Heart Failure
… uptitrate dosages of beta-adrenergic blockade (β-blockers), angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) to the most tolerable levels in order to reach target dosages, as recommended by the Heart Failure Society of America (HFSA). Patients were …
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The relationship between reduced renal function and cardiovascular disease
… and risk of CVD in patients treated with β-blockers and/or thiazide diuretics and in patients treated with the Ca+-channel blocker diltiazem. In patients with hypertension, creatinine and CG predicted CVD endpoints in a linear fashion, whereas the risk associated with MDRD increased steeply …
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