Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Blimp1"”.
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Regulation des Blimp1-Promotors durch die Transkriptionsfaktoren C/EBP-Beta und NFATc1 in T-Lymphozyten
Das murine Blimp1 (B lymphocyte-induced maturation protein) und sein humanes Homolog PRDI-BF1 (positive regulatory domain I binding factor 1) sind als terminale Differenzierungsfaktoren der myeloischen Reihe und der B-Lymphozyten (BCs) beschrieben worden. Über direkte sequenzspezifische …
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LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1
… SET domain-containing transcriptional repressor BLIMP1/PRDM1. BLIMP1/PRDM1 and its orthologs are well studied as transcriptional repressors in many species including humans and mice. Interestingly, we found that in C. elegans, BLMP-1 acts as a direct transcriptional activator of bed-3, a gene …
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… I was able to confirm that loss of PRDM1/Blimp1 homolog blmp-1 served as a strong enhancer of the let-60(n1046) Muv phenotype. In addition, blmp-1(tm548) mutant worms are not Muv. I chose to investigate one of these genes, called blmp-1, in great detail because of known roles of its …
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Topographie molekularer Faktoren der Keimzellentwicklung während der frühembryonalen Entwicklung des Kaninchens
… die Expressionsmuster der Schlüssel-Gene Blimp1, BMP2 und BMP4 untersucht und mit aus dem Mausmodell bekannten Daten verglichen. Für die Untersuchungen wurde das Kaninchen als Modellorganismus ausgewählt, weil es mit seiner flachen Keimscheibe für den Säugerembryo besonders repräsentativ …
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Early divergent B cell differentiation during antibody responses
… precedes CD138 protein, which in turn precedes Blimp1 expression
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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo
… hPGC specification, we find that upregulation of BLIMP1 alone, a canonical regulator of PGCs, is sufficient to induce later markers of hPGC fate, and surprisingly is also sufficient to downregulate SOX2 (a marker of epiblast and early ectodermal fate) and upregulate SOX17, which has been …
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… POU5F1 (OCT4), IFITM3 (fragilis), STELLA, PRDM1 (BLIMP1), and C-KIT, indicating their early germline nature. Investigation of neo-oogenesis potential revealed that putative human OSCs were associated rarely with fetal somatic cells in primordial follicle-like structures, but could not be confirmed …
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A Leap of Fate: Fluid identity, functional modules, and flexible strategies for transcription factor-based reprogramming
… on the existing method of XBP1 or PRDM1/BLIMP1 over-expression. Chapter 5 attempts to address how predictive framework might be adapted for the design of a truly synthetic cell type: a functionally defined target cell. It proposes the concept of a reprogramming dictionary, comprising …