Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Blimp-1"”.
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Blimp-1 Regulates Terminal Differentiation of T Cells
The transcriptional repressor-Blimp-1 terminates differentiation of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral …
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Regulation der terminalen B-Zell-Differenzierung durch Blimp-1
… des Keimzentrums. Der Transkriptionsfaktor Blimp-1 ("B lymphocyte induced maturation protein 1") wird als ein „Mastergen“ der terminalen B-Zell-Differenzierung betrachtet und ist in der Lage, die komplexen Differenzierungsprozesse zu Ig-sezernierenden Plasmazellen auszulösen und …
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Einfluß von Blimp-1 auf die Interferonproduktion und Virusvermehrung
… sich mit der Frage, ob der Transkriptionsfaktor Blimp-1 ebenso wie sein humanes Äquivalent PRDI-BF1 die Interferonproduktion reprimiert und somit die Virusvermehrung in Zellen erleichtert. An Blimp-1 exprimierenden L929-Zellen wurde die Interferonproduktion mit Hilfe des RNase Protection Assay …
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Regulation of B lymphocyte terminal differentiation and death by the transcription factor Blimp-1
B lymphocyte induced maturation protein-1 (Blimp-1) und X-box-binding protein-1” (XBP-1) sind als Transkriptionsfaktoren unverzichtbar für die terminale Differenzierung von B-Lymphozyten zu Immunglobulin (Ig)-sezernierenden Plasmazellen. Ebenso stellen die unfolded protein response (UPR) und das …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… Whereas the transcription factors Bcl6, Blimp-1, and STAT3 regulate the development of Tfh cells, T-bet and STAT4 direct the commitment of Th1 cells. Since our understanding of the regulation of adaptive protective responses against malaria is poor, the present dissertation aimed to study …
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Investigating the Effect of Antibody-Mediated Feedback on Ongoing Germinal Center Responses
… In addition, we have genetically engineered a Blimp-1-DTR mouse that allows for temporally controlled ablation of plasma cells and, therefore, depletion of antibody titers. Combining these two models has revealed that high levels of antibody produced during B cell responses can modulate …
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Targeting T Cells for the Immune-Modulation of Human Diseases
… functional repressor of the transcription factor Blimp-1, which promotes CTL cytotoxicity and effector cell differentiation. In a cohort of advanced lung cancer patients, miR-23a was upregulated in tumor-infiltrating CD8+ T cells, and its expression correlated with impaired antitumor potential of …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… of in vitro expanded B cells revealed increased Blimp-1 and Notch3 expression in myr PKB tg B cells, which might be primary candidates involved in their enhanced effector function. In summary, this study clearly shows an important cross-talk between PKB and various critical signalling molecules …