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Showing 1 to 20 of 36 for “"Bleomycin"”.
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DNA double-strand cleavage mediated by bleomycin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Mechanisms and Intermediates of Iron Bleomycin Catalyzed Oxidations
… metallo-systems, it is presumed that iron bleomycin generates a reactive oxygen intermediate by the reductive cleavage of the dioxygen O-O bond. The molecular details of this activation and the exact chemical nature of the resulting intermediate has remained largely undefined. The ability …
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Genetic requirements for protection against bleomycin toxicity in Escherichia coli
Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare the relative sensitivities of a wild type Escherichia coli strain to a panel …
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Comparison study of Taurolidin, Talc, Tetracycline and Bleomycin Pleurodesis in the Rabbit Model : Analysis of the Taurolidin's effectiveness
… such as Talc, Tetracycline, Doxycycline and Bleomycin have been used to induce pleurodesis. These agents have some limits of these use. Therefore some have used Taurolindin (Taurolineⓡ) as chemical irritant which is inexpensive, nontoxic and easy to deal. However it has not been investigated …
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Mechanistic studies of bleomycin-mediated double-stranded DNA cleavage and structural studies of DNA containing normal and 4'-oxidized abasic sites
… (ds) DNA cleavage mediated by a single bleomycin (BLM), a bulky group ([-cyclodextrin) was chemically attached to the polyamine tail of BLM A5 to prevent the intercalation of the bithiazole tail. The ability of this analog (CD-BLM) to effect ds-DNA cleavage was quantitatively analyzed …
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Das Dhh1 Protein aus Saccharomyces cerevisiae
… Sensitivität von Hefezellen sowohl ge-genüber Bleomycin als auch gegenüber MMS. Allerdings zeigten dhh1D-Zellen nur eine schwache Sensitivität gegenüber UV-Strahlung und keine Sensitivität gegenüber g-Strahlung. Dies weist sehr stark darauf hin, dass die beobachteten Sensitivitäten auf einem …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. Firstly MSC expansion of Treg cells was shown to be dependent on Jagged 1 signalling. MSC inhibition of DC maturation and antigen presentation was shown to also involve Jagged 1 however IL-6 signalling is also …
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ΠΑΘΟΓΕΝΕΙΑ ΤΩΝ ΠΝΕΥΜΟΝΙΚΩΝ ΑΛΛΟΙΩΣΕΩΝ ΜΕΤΑ ΑΠΟ ΧΟΡΗΓΗΣΗ ΜΠΛΕΟΜΥΚΙΝΗΣ: ΙΣΤΟΠΑΘΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΣΕ ΜΥΣ C57BL
ADULT C57BL MICE WERE TREATED WITH BLEOMYCIN, WITH DOSES EQUIVALENT TO THOSE RECOMMENDED FOR HUMANS, FOR A PERIOD OF 4, 8 AND 16 WEEKS AND THEIR LUNGS WERE STUDIED BY LIGHT MICROSCOPY. THE PATHOGENESIS OF THE LOWER AIR-WAYS FIBROSIS IS DISCUSSED IN DETAIL.
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Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
… (PF). After exposure to the PF-inducing agent bleomycin, only constructs containing macrophages exhibited excessive collagen deposition and developed PF. Bleomycin exposure resulted in production of pro-inflammatory cytokines IFN-γ, TNF, IL-1β, and IL-6. MMP-7 expression was found in alveolar …
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Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
… to characterize the contribution of CDH11 in the bleomycin model of PF and assess the feasibility of treating established PF. We demonstrate CDH11 in macrophages and airway epithelial cells undergoing EMT in lungs of mice given bleomycin and patients with PF. Endpoints consistent with PF including …
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The behavior of RAD51D and XRCC2 in response to drug induced DNA damage and a continuing study of the fly RAD51 paralogs
… one hour after the induction of DNA damage via bleomycin, dmRad51D and dmXRCC2 entered the nucleus of the Drosophila culture cells, where they remained for the next three to four hours. Following this period in the nucleus, the cells were visualized moving back into the cytosol. The second …
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Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
… administered with a single dose of bleomycin (BLM) to study the implication of IGF1R in acute lung inflammation. In addition, eight- to 10-week-old female CreERT2 mice were intranasally challenged with house dust mite (HDM) five days per week for four weeks to study the implication …
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
… To achieve this aim, we have introduced in our bleomycin (BLM)-induced mouse model (Stellari et al. 2017), novel readouts such as the Forced Vital Capacity (FVC) and the Diffusion Factor for Carbon Monoxide (DFCO) that are poorly used in preclinical practice but that are respectively the primary …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… were subjected to intraperitoneal injections of bleomycin twice a week for four weeks. Results demonstrated that <em>IL-6<sup>-/-</sup></em> mice developed reduced pulmonary fibrosis. To examine a therapeutic approach in this model, wild type mice exposed to bleomycin were treated with IL-6 …
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An audit of endocrine dysfunction in children with craniopharyngiomas at Red Cross Children's Hospital and Groote Schuur Hospital from 1976 to 2004
… with a further 6 patients receiving intratumoral bleomycin for recurrences. Post operatively the majority of children were on replacement therapy but only 6 patients (14%) received human growth hormone or are receiving human growth hormone currently due to a lack of funds to provide human growth …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
… macrophages (BMDMs) and in vivo models of bleomycin-induced pulmonary fibrosis. These players will be valuable as potential clinical targets to halt differentiation of macrophages into the reparative AAM subtype and attenuate their subsequent pro-fibrotic role. Ultimately, these …
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Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
… efficacy following late MSC administration. In a bleomycin mouse model of fibrosis, MSC again displayed significant cytoprotective effects with early MSC intervention. Decreased epithelial apoptosis and collagen deposition were observed with MSC treatment with HGF demonstrated to be important in …
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ROLES OF INOSITOL DIPHOSPHATES IN DNA REPAIR AND EFFECTS OF ASPIRIN ANALOGUES ON OESOPHAGEAL CANCER
… crucial in repair of DNA following insult with bleomycin and 5-fluorouracil. The observed sensitivity of the mutants was thought to be due to lack of functional repair protein, UDG-like or APE-like, in the absence of essential cofactor such as IDPs. Experiments conducted revealed that the …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… deaminase-deficient mouse model and the bleomycin-induced pulmonary injury model to determine the distinctive roles of the A2BR at different stages of the disease. Results demonstrate that the A2BR plays a protective role in attenuating vascular leakage in acute lung injuries and a …
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MICROGRAVITY NEGATIVELY AFFECTS DNA DAMAGE REPAIR AND THE ANTI-LEUKEMIC FUNCTION OF HUMAN NATURAL KILLER CELLS
… DNA lesions induced with the radiomimetic drug bleomycin, as assessed by γH2AX foci. Furthermore, brief exposure of human NK cells to conditions of μG dramatically reduced the cytotoxicity of NK-92MI cells against two different human leukemic cell lines. Studies utilizing activated primary NK …
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