Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Blebbing"”.
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Bleb-driven chemotaxis in Dictyostelium discoideum
… but in more physiological conditions, blebbing motility is also apparent. It has been shown that certain cells even can switch between these two modes of motility, although it is not known how this switch is triggered. Besides, it is unclear whether blebbing can be regulated by …
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New Types of Morpho-Physiological Changes in Cells Exposed to Nanosecond Pulsed Electric Field
… that is manifested in swelling and diffuse blebbing. Recently we identified two new distinct forms of reshaping, pseudopod-like blebbing and microvesiculation, which are present in cells exposed to long trains of nsPEF with high pulse repetition frequency (PRF). Microvesiculation is known in …
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Modelling Physical Mechanisms Driving Tissue Self-Organisation in the Early Mammalian Embryo
… we introduce dynamic tension to model blebbing in primitive endoderm cells. We investigate the effects of cortical tension, differential interfacial tension, and blebbing on interfaces, rearrangement, and sorting. By establishing quantitative measurements of sorting we produce phase …
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The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases
… DNA fragmentation and chromatin condensation, "blebbing" of the plasma membrane, and subsequent phagocytosis of the resulting cell fragments by adjacent cells (Kerr et al. 1972 and Wyllie et al. 1980).
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Investigation into the antimicrobial activity of cationic antibacterials.
… formation of spherical aggregates; membrane blebbing and inhibition of normal bacterial septation. Similar responses to NP101 and NP108 were observed to the test bacteria; an all or nothing effect on bacterial growth; prevention of second phase logarithmic growth in S. aureus; induction of …
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Control of DAPK-1 degradation
… does mimic DAPK-1’s function to induce membrane blebbing. The proteolytically processed form of s-DAPK-1 is more active in the induction of membrane blebbing, which may be due to its higher stability compared to that of full-length s-DAPK-1, suggesting that the tail region can control s-DAPK-1 …
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N-ethylmaleimide sensitive factor (NSF) is a regulator of plasma membrane rupture and necrotic cell death
… that NSF localizes to sites of membrane blebbing and rupture. Additionally, SNARE-binding, ATPase activity, and redox modification are necessary for NSF’s role in necrosis. We generated conditional Nsf knockout mice and induced skeletal muscle injury via cardiotoxin injection. Loss of NSF …
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Synergic Effect on Cell Death by Co-treatment with TRAIL and Human Anti-DR5 Antibody
… that the cells were dying with both apoptotic (blebbing and DNA fragmentation) and autophagic features (autophagosome containing organelles). Analyses of each signaling markers (apoptosis; PARP cleavage and autophagy; increased LC3-II form) induced by TRAIL, HW1 and combination of them showed …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
… mechanisms, including nonapoptotic migratory blebbing. In the fourth chapter, we address the importance of non-endothelial factors in MSC trafficking to inflamed tissues, including mechanical trapping in small vessels, secondary interactions with endogenous immune cells and vascular …
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Zelluläre Funktionsstudien zum Wirkungsmechanismus von Shiga Toxinen bei mikro- und makrovaskulären Endothelzelllinien
… Ausbildung von Membrankörperchen (das sog. blebbing) und Lücken im Zellmonolayer durch Zellablösung verursacht, sind nach Inkubation mit Stx2 lediglich eine leicht veränderte Form der Zellen sowie blebbing zu beobachten. Diese morphologischen Untersuchungen, insbesondere das Ausbleiben von …
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An Evaluation of the Occurrence of Micronuclei and other Nuclear Abnormalities in Fishes from the Great Lakes Basin, United States
… abnormalities (NA) such as notching, lobes, blebbing, and binucleation are observed from the nuclear membrane and are indicators for mutagenic contamination. The micronucleus assay was incorporated to assess genotoxic and mutagenic contamination among sites, species, and season from fish …
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Plasma membrane-derived vesicles: their role in the terminal differentiation of monocytes and in inhibiting the phagocytosis of apoptotic cells
… when cells undergo activation/apoptosis via blebbing and shedding and have a function in intercellular communication. Exposition of phosphotidylserine (PS) on the outer membrane leaflet that mark them as a biologically distinct entity could explain a role for PMVs in phagocytosis and …
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Mechanisms of microparticle release from human platelets
… sequestered from the platelet membrane. Membrane blebbing and scission in this process were independent of influx of hydrophilic ions or the endosomal sorting complex required for transport. It was found that microparticles were also released from platelets undergoing apoptosis, which would …
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… by chromatin condensation, membrane blebbing, and cytoplasm compaction, and molecularly by the activation of caspase proteases, has been extensively investigated. Studies in C. elegans, Drosophila, mice, and the developing chick have revealed, however, that developmental PCD also …
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Increased Apoptosis in the Host By Guanidine Hydrochloride Treatment of Infectious Pancreatic Necrosis Virus
… membrane, followed by cell shrinkage and cell blebbing. DNA isolates from apoptotic cells typically present a laddering effect on agarose gels. Recent publications indicate the early protein products of some viruses are able to repress apoptosis within their host. Particles or empty capsids …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… potential. While TRAIL induced apoptotic blebbing, caspase-3 processing, and apoptotic LEDGF/p75 cleavage, which leads to its inactivation, in both taxane- resistant and -sensitive PC3 and DU145 cells, treatment with DTX and CBZ failed to robustly induce these signature apoptotic events. …
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Deterministic design of peptide-membrane interactions
… condition for processes such as pore formation, blebbing, budding, vesicularization, all of which destabilize the barrier function of cell membranes. The topological requirement for saddle-splay curvature places constraints on the amino acid compositions of membrane disruptive peptides. In AMPs …
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Directed Migration Achieved in Mammalian Cells via Ca2+ Signal Rewiring in Synthetic Protein Chimeras
… we re-wired, for example, dynamic cellular blebbing to increases in extracellular free Ca2+. Next, we validated this design strategy in two systems, i.e., inflammatory cytokines such as TNFα and antibodies. A system of proteins was used: an engineered TNFα chimeric receptor (named TNFR1chi), …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… morphological features of plasma membrane blebbing and F-actin cytoskeleton disruption were observed. In order to define apoptotic pathway, evaluation of mitochondrial function illustrated no intracellular release of mitochondrial proteins, cytochrome c, second mitochondria-derived …
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Antibacterial activity and mode of action of the antimicrobial peptide CPF-MW1 against Escherichia coli ATCC 700928
… microscopy showed that CPF-MW1 caused membrane blebbing and damage, resulting in cell death. For further application in physiological environments, the stability of the peptide in a proteolytic environment and in fetal calf serum (FCS) was evaluated. At the MBC, CPF-MW1 was degraded by trypsin, …
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