Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Blastema"”.
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Development of transgenic Ambystoma mexicanum (axolotl) to study cell fate during development and regeneration
… in characterization of pluripotency of blastema cells. Previously, it has been shown that neural progenitor cells form the spinal cord can transdifferentiate to muscle and other tissue types in the regenerating tail. To test if blastema cells have the potency of differentiating into a …
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Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum
… Urodele tail and limb regeneration occurs via blastemal epimorphic regeneration. A blastema is a mound of progenitor cells that accumulates at the amputation plane and eventually gives rise to the missing structures. It is known today that dedifferentiating muscle fibers at the amputation plane …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
… thesis has been to establish biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are …
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Molecular Characterization of Early Dedifferentiation in Newt Forelimb Regeneration
… of stump tissue and the formation of a blastema, which provides the majority of cells for the regenerate. Despite all that we have learned about dedifferentiation and blastema formation, the cellular and molecular mechanisms underlying these processes are still poorly understood. We used …
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Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum
… revealed that different subpopulations of blastema cells exist regarding two aspects. First, we found that progeny of skin and skeleton have some tissue specific memory since they did not give rise to muscle lineages. However, cells of the skin contributed to other mesenchymal tissues like …
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The Effects of Retinoids on Regenerating Axolotl Limbs
… basis for this rule is the inheritance by the blastema of a cellular memory of its position of origin, termed positional value. Recently, vitamin A and its derivatives (retinoids) have been found to proximalize positional value, causing duplication of stump structures in the regenerate. …
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"The use of retinoids and an in vivo ""affinophoresis"" assay to analyze the cellular basis of positional memory in regenerating axolotl limbs"
Amphibian limb regeneration blastema cells normally regenerate only those parts distal to the amputation plane, and have been shown to inherit an expressed memory of their position of origin, termed positional value, by developing autonomously when grafted away from their normal limb site, and by …
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Purification of A Serum Factor That Triggers Cell Cycle Re-entry In Differentiated Newt Myotubes
… the appearance of a mesenchymal growth zone or blastema in these regenerative species instead of the scarring seen in mammals. This blastema is thought to largely derive from the dedifferentiation of various functional cell types, such as skeletal muscle, skin and cartilage. In the case of …
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ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS
… B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. …
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Estadios iniciales de la morfogénesis discovertebral
… que en el adulto. En embriones de 3,5 mm el blastema esclerotómico pericordal, está formado por cartílago en estado embrionario epecializado, que envuelve a la notocorda. En embriones de 6 mm, se produce división en segmentos de la columna blastemática. En embriones de 14 mm, la notocorda, …
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Multi-stressor impacts of ocean warming and acidification on the regeneration andbiomineralisation of <i>Psammechinus miliaris</i>
… feet, following the stages of wound-healing, blastema formation, differentiation and innervation, and growth. Elevated temperatures significantly increased regeneration and calcification rates, surpassing the species’ thermal niche, while low temperatures hindered regeneration. Acidification …
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Cloning of actin genes from a genomic library of the newt, Notophthalmus viridescens
… manipulate mitogenic influences upon the blastema, as well the morphogenesis of the regenerating 11mb. Although classical regeneration studies have generated a wealth of knowledge concerning tissue interactions, little 1s known about the process at the level of gene expression. The aim of …
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Studies in Amphibian Limb Development and Regeneration
… to analyze specific whole limb and regeneration blastema events. The most interesting of these events are those that occur during the developmental stages when the anuran Xenopus laevis is experiencing the most abrupt losses in the ability to regenerate hindlimbs after amputation. We have dealt …
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Organizer regeneration and patterning of stem cell lineages in planarians
… midline, and coalesce to the DV boundary in the blastema. These findings demonstrate that during its formation, the anterior pole integrates positional information from the pre-existing tissues. This process places the anterior pole in the appropriate location to organize patterning during head …
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Rapid Non-genomic Actions of Cortisol in Fish
… cell proliferation of ORAI1 expressing cells and blastema formation was evident at 24 h in response to cortisol stimulation, but absent in the GR knockout and MR knockout larvae, suggesting that this CRAC channel protein may be both non-genomically and genomically regulated by cortisol. Taken …
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Expressão imunoistoquímica de ácido retinóico, CRABP2, NFkB p100 e p105, TRAP1 e TWEAK em nefroblastomas
… Todos os tipos histológicos do nefroblastoma (blastema, epitélio e estroma) foram positivos para as seis proteínas estudadas. AR pela análise morfométrica e CRABP2 pela análise semiquantitativa apresentaram maior expressão imunoistoquímica nos pacientes com metástase (p= 0.0247 e p= 0.0128, …
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hyaluronic acid networks in wound healing
Regeneration is the process by which an organism fully restores the form and function of damaged tissues. Mammals, however, have a limited capacity for regeneration, and the mechanisms underlying incomplete or abnormal healing are poorly understood. Diseases that hinder regeneration in humans often …